Complement deficiencies Flashcards

1
Q

Actions of complement system

A

chemotaxis, cell lysis and opsonisation

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2
Q

C1 inhibitor (C1-INH) protein deficiency

A

causes hereditary angioedema
C1-INH is a multifunctional serine protease inhibitor
probable mechanism is uncontrolled release of bradykinin resulting in oedema of tissues

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3
Q

C1q, C1rs, C2, C4 deficiency (classical pathway components)

A

predisposes to immune complex disease
e.g. SLE, Henoch-Schonlein Purpura

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4
Q

C3 deficiency

A

causes recurrent bacterial infections

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5
Q

C5 deficiency

A

predisposes to Leiner disease
recurrent diarrhoea, wasting and seborrhoeic dermatitis

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6
Q

C5-9 deficiency

A

encodes the membrane attack complex (MAC)
particularly prone to Neisseria meningitidis infection

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7
Q
A
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