Cell cycle Flashcards
‘resting’ phase
quiescent cells such as hepatocytes and more permanently resting cells such as neurons
G0
Gap 1
cells increase in size
determines length of cell cycle
under influence of p53
G1
What regulatory proteins are involved in G1 phase of the cell cycle
Cyclin D / CDK4
Cyclin D / CDK6
Cyclin E / CDK2
regulates transition from G1 to S phase
Synthesis of DNA, RNA and histone
centrosome duplication
S phase
What regulatory proteins are involved in S phase?
Cyclin A / CDK2
Gap 2, cells continue to increase in size
G2
Regulatory proteins involved in G2
Cyclin B / CDK1: regulates transition from G2 to M phase
Mitosis - cell division
the shortest phase of the cell cycle
M phase
Which phase of the cell cycle determines the length of the cycle?
G1