Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PSYCH 478 > Cocaine > Flashcards

Cocaine Flashcards

1
Q

true or false - psychostimulants and stimulants are the same

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

true or false - psychoactive drugs produce a decrease in mental function

A

false - increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are four psychostimulants

A

cocaine, amphetamines, caffeine, nicotine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

where is the pscyhoactive alkaloid isolated from

A

coco shrub

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the best way to administer psychoactive drugs to get the best effects and why

A

oral -> when you chew the leaves with lime then it reduces the hydrolysis -> more effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what was something you could drink that has the cocaine hit without alcohol

A

coca cola

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the harrison act

A

all narcotics given out have to be through prescription

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is mariani wine

A

it is cocaine + wine concotion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

true or false - crack cocaine is considered as an epidemic

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the 3 ways cocaine can be given

A

oral , intranasal or IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

cocaine can be recrystallized as a _______

A

free base

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

crack cocaine can be made by heating cocaine with _______

A

baking soda

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

how is crack cocaine and free base cocaine delivered

A

inhalation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how is illicit cocaine purified

A

leaves are chopped and mixed with lime or cement and then left to soak for 24 hours -> pressed to create a crude extract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

how is free base cocaine purified

A

extracted by neutralization with an acid -> precipitated with NaOH -> dried paste is made with 60% pure cocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

true or false - IV cocaine lasts a long time

A

false - enters quick but does not last long

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

true or false - cocaine thru intranasal takes long time to enter and stays long time

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what are the two administrations for rapid access ways to the CNS

A

inhalation and intranasal

19
Q

how is cocaine metabolized (what enzyme)

A

esterases -> CYP450 in liver

20
Q

what is cocaethylene

A

active metabolite made in the presence of alcohol -> greater cardiotoxic effects

21
Q

what is methylecgonidine

A

produced by heating of cocaine and can be found in urine

22
Q

true or false - cocaine is hydrophillic

A

false - it is amphipathic

23
Q

true or false - cocaine can pass BBB

A

true

24
Q

what are 5 effects of cocaine

A

insomnia, inflated self esteem, anorexia, psychosis and increased HR

25
Q

what are two subjective effects of cocoaine

A

euphoria and dysphoria

26
Q

true or false - cocaine administration results in locomotor hyperactivity

A

true

27
Q

what are common stereotyped behaviors

A

bobbing, pacing, excess grooming

28
Q

do animals self administer cocaine

A

yes to the point of anorexia and death

29
Q

how can you tell rodents are intoxicated

A

by hyperactivity

30
Q

true or false - cocaine is a SSRI

A

false - it is an SNDRI (serotonin, NE and dopamine reuptake inhibitor)

31
Q

cocaine blocks what transporter

A

DAT

32
Q

cocaine blocks __ channels and can be used as a _______ in humans

A

Na / topical anaesthetic

33
Q

how does cocaine decrease monoamine synthesis

A

through presynaptic autoreceptors

34
Q

cocaine tolerance develops _____ and ______

A

acutely and transiently

35
Q

true or false - intermittent use produces tolerance

A

false - sensitization

36
Q

in animal models, continuos infusion results in______

A

tolerance to effects

37
Q

true or false - both humans and animals show cross sensitization to other stimulants

A

true

38
Q

does withdrawal to cocaine have serious effects

A

no

39
Q

what are the three phases of binge users

A
  1. crash
  2. withdrawal
  3. extinction
40
Q

what are some acute withdrawal effects

A

dysphoria, strong craving, fatigue, prolonged sleep and hyperphagia

41
Q

which phase does dysphoric syndrome occur

A

withdrawal

42
Q

what is dysphoric syndrome

A

boredom, anxiety and increased craving

43
Q

how is overdose treated

A

administers a sedative (benzo) to decrease HR and BP -> use of ice

44
Q
A

PSYCH 478 (28 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions