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Pharmacology > Cns > Flashcards

Cns Flashcards

1
Q

Doc for primary parkinsonism

A

Levodopa

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2
Q

On off effect seen in

A

Late parkinsonism

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3
Q

Mao B inhibitors in parkinsonism

A

Irrev- Seligilline
Rasagilline
Rev- safinamide

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4
Q

COMT inhibitors- catechol O methyl transferase

A

Tone-
Entacapone
Nitecapone
Opicapone
Tolcapone

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5
Q

Nmda antags in parkinson

A

Amantadine

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6
Q

Dopamine agonists

A

Ergots-
Bromocriptine
Cabergoline

Non ergots- PRA
Pramipexole
Ropinrole
Rotigotine
Apomorphine

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7
Q

Management of parkinsonism

A

No funcctional impairment- rasigiline
Func imp- levodopa
To reduce periph S/E- add bensarazide + Amantadine
Prolong on- Entacapone
Rescue off- Apomorphine
Vomiting - donperidone
Psychosis- clozapine, quetiapine, pimavanserin
Resting tremors- Benzhexol, promethazine

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8
Q

Doc for drug induced parkinsonism

A

Bbb
Benzhexol
Benztropin
Biperiden

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9
Q

Doc for intermittent restless leg synd

A

Levodopa
Carbidopa

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10
Q

Chronic resltlesd leg synd doc

A

Pregabalin
Gabapentin
Ropinrole
Pramipexole

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11
Q

Doc in huntingtons

A

Dopamine depletors- VMAT 2 inhibitors-
Tetrabenazine
Deutetrabenazine
Valbenazine

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12
Q

Doc for rheumatic chores- sydenham’s chorea

A

Valproate or carbamazapine- prednisolone

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13
Q

Doc for tourette syn

A

Guanephecine, clonidine- atypical anti psych- typical anti psych
If adhd + tourette- Atomoxetine

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14
Q

Doc for Wilson’s ds

A

Zn - dec absorption of cu in gjt
Liver damage - trientene - penicillamine- liver ts
Cns- tetrathiomolybdate

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15
Q

ALS doc

A

Neuroprotectives - Riluzole
Edaraxone
Muscle relaxants
Anticholinergics
Dexomethophan, quinidine

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16
Q

Progeria doc

A

Lonafarnib

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17
Q

Acute attack Multiple sclerosis doc

A

Methyl prednisolone

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18
Q

For long term MS DOC

A

Rrms- interferon beta
Spms- mitoxantone
Ppms- ocrelizumab

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19
Q

Dis modifying drugs for MS

A

Go find dat cm
Glatimeracetate
Ocrelizumab
Fingolimod
Inf beta
Natalizumab
Dimethyl fumarate
Daclizumab
Alemtuzumab
Terflunomide
Cladribine
Mitoxantrone

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20
Q

Sedatives nd hypnotics

A

Barbiturates
Bzd
Atypical bzd
Melatonin
Alchohols
Opiods
Anti histamines
Tca

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21
Q

Antidote for bzd

A

Flumazenil

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22
Q

Ultra short acting barbiturates

A

Thiopentone
Methohexitone

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23
Q

Doc for ect

A

Methohexitone

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24
Q

Short acting barbiturates

A

Butabarbitone
Amobarbitone
Pentabarbitone
Secobarbitone

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25
Q

Long acting barbiturates

A

Phenobarbitone
Primidone

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26
Q

Doc for neonatal jaundice

A

Phenobarbitone

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27
Q

Bzds

A

Anti seizures- diazepam
Lorazepam
Clonazepam
Clobazepam
Midazolam

Pre anaesthetic- diazepam
Lorazepam
Midazolam
Remimazolam

Insomnia- flurazepam
Temazepam
Estazolam
Quazepam

Anti anxiety- diazepam
Clonazepam
Oxazepam
Lorazepam

Muscle Relaxants- diazepam
Baclofen

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28
Q

Acute attack of anxiety doc

A

Propanolol

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29
Q

Bzd safe in liver ds

A

Lorazepam
Oxazepam
Temazepam
Estazolam

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30
Q

Longest acting bzd

A

Flurazepam

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31
Q

Date rape drugs

A

AK Bas GF
Alchohol
Ketamine
Barbiturates
Gamma hydroxybutyrate
Flunitrazepam- roofie

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32
Q

Drugs for insomnia

A

Barbiturates- inc NREM
Atypical Bzd
Melatonin

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33
Q

Atypical bzd

A

Z drugs
Zopiclone
Zopidem
Zaleplon

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34
Q

Melatonin analogs

A

Ramelteon- jet lag
Tasimelteon- blind ppl circadian rhythm

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35
Q

Drug inhibiting alchohol dehydrogenase

A

Fomepizole

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36
Q

Drug inhibiting aldehyde dehydrogenase

A

Disulfiram

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37
Q

T/t of alchohol poisoning

A

Shafe
Sodium bicarbonate
Hemodialysis
Antidote- fomepizole
Folic acid
Ethanol

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38
Q

Addiction syndrome

A

Acute withdrawal syndrome- delirium, tremors, korsakoff psychosis

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39
Q

Detoxification of alchohol, maintainance phase doc

A

Chlordiazepoxide

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40
Q

Anti craving for alchohol

A

Oral naltrexone+ acamprosate

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41
Q

Deterrent for alchohol

A

Disulfiram

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42
Q

Disulfiram reaction

A

Flushing, abd pain, nausea, headache, hypotension

43
Q

Drugs showing disulfiram like reaction

A

CGMP-
Chlorpropamide
Griseofulvin
Metronidazole
Procarbazine

44
Q

Natural opiods

A

Analgesic- morphine, codeine
Non analgesic- papaverine, noscapine, thebaine

45
Q

Effect of u receptor

A

Sacrum no gap
Sedation
Analgesic
Constipation, cough
Resp depression
Euphoria
Miosis
Nausea vomiting
Gall stones
Abdominal colic
PRL release

46
Q

Least potent opiod

A

Codeine

47
Q

Opiods as antitussives

A

Codeine
Hydocodone
Oxycodone
Morphine
Hydromorphone
Oxymorphone

48
Q

Non addictive anti tussives

A

Dectromethorpham
Noscapine

49
Q

Doc for opiods in preg
Doc for post anesthetic shivering

A

Pethidine

50
Q

Doc of day care surgery

A

Remifentanyl- shortest opioid

51
Q

Neurolept analgesic

A

Fentanyl + droperidol

52
Q

Doc in opiod deaddiction

A

Methadone- longest opioid

53
Q

Mixed acting opiods- partial kappa agonist nd u antag

A

PNB
pentazocine
Nalbuphine
Butarphanol

54
Q

Pure kappa agonist

A

Nalfurafine
Eluxlodine
Asimadoline

55
Q

Partial u agonist nd kappa antag

A

Buprenorphine
Dezocine

56
Q

Pure antags of all all opiod receptors

A

Naloxone
Naltrexone
Nalmeftane

57
Q

Opiod addiction tt

A

Acute overdose- naloxone
Maintenance- BMT
buprenorphine, methadone, tramadol

58
Q

Morphine nd congeners- u agonist

A

Morphine
Codeine
Fentanyl
Remifentanyl
Pethidine
Methadone
Tramadol

59
Q

Mood stabilisers

A

Low
VOLTAGE
lithium
Valproate
Oxcarbazepine
Lamotrigin2
Topiramate
Anti psych
Gabapentin

60
Q

Acute mania doc

A

Lithium
Anti psych
Valproate

61
Q

Doc rapid cycling Bipolar ds

A

Valproate

62
Q

Maintenance of bipolar ds

A

Oral lithium

63
Q

Lithium uses

A

BHAR
bipolar ds
Hypnic headache
Anti suicidal
Resting depression

64
Q

Adverse effects of lithium

A

LITHIUMS
Leucocytosis
Inc wt, thirst
Tremors
Hypothyroidism
Inc nausea, vomiting, diarrhea
Urination
Mental seizures
Skin

65
Q

Ecg changes caused by lithium

A

Flattening of t wave
Increase PR interval

66
Q

Lithium in preg causes

A

Ebstein anomaly
Goitre
Hypotonia- floppy baby

67
Q

Types of epilepsy

A

Generalised- GTCS, Absence, atypical absent seizures

Focal

68
Q

First line drugs for generalised seizures

A

GTCS- lamptrigine, valproate
Ab seizure- lamotrigine, valproate, ethosuximide

69
Q

2nd line druga for gen seizures

A

Gtcs- many
Ab seizure- clonazepam, zonazepam, levitiracetam

70
Q

Focal seizures 1st line

A

LoC pl
Lamotriginw
Oxcarbamazepine
Carbamazepine
Phenytoin
Levetiracetam

71
Q

Lennox gestatt syndrome

A

Doc valproate– clobazam– rufinamide— fenoldapam

72
Q

Dravel’s syndrome- severe myoclonal epilepsy of infancy

A

Valproate– clobazam– stiripentol

73
Q

Doc for infantile spasm

A

Vigabatrin

74
Q

Doc for febrile seizures

A

Rectal diazepam

75
Q

Epilepsy in preg

A

If already epileptic - in preg- add folic acid- 4000 mg
Vit K 10mg

If planning- stop Aed- start levetiracetam, lamotrigine

76
Q

Status epilepticus

A

5-10min- lorazepam, clonazepam, midazolam
30 min- midazolam, propofol
I/v phenobarbitone
48 hrs- lobectomy, hypothermia
Isoflurane, desflurane, ketamine

77
Q

Classification of AED

A

Na ch blockers
Ca ch blockers
Cl ch openers
K efflux
Glu rls inhibitors
Glu receptor blockers

78
Q

Na ch blockers

A

PCV ToLL
Phenytoin
Carbamazepine
Valproate
Topiramate
Lamotrigine
Lacosamide

79
Q

Phenytoin side effects

A

CCC
cerebellar toxicity
Cerebral toxicity
Cardiac arrythmias
Hyperplasia of gums
Hirsutism
Heavy wt- obesity
Hyperglycemia
Hypersensitivity
Hampers vit absorption
Hodgkin like pseudolymphoma
Hydantoin synd

80
Q

Carbamazepine s/e

A

Shades
Steven johnson
Hepatotoxic
Aplastic anemia
Diplopia
Esoniophilia
Siadh

81
Q

Ca ch blockers

A

VELT
valproate
Ethosuximide
Lamotrigine
Trimethadine

82
Q

Valproate side effects

A

VALPROATE
Vomiting
Alopecia
Liver toxicity
Pancreatitis
Rashes
Obesity
Amm level inc
Tremors
Enz inhibitor

83
Q

Druga promoting gaba - A Cl ch

A

Barbiturates- phenobarbitone, mephobarbitone, stiripentol
Bzd- diazepam, lorazepam, clonazepam, clobazam, midazolam
Pregabalin, gabapentin
Tigabine
Vigabatrin

84
Q

Drugs inhibiting glutamate rls

A

Levetiracetam
Brivaracetam

85
Q

Drugs blocking glu receptor

A

Nmda- Felbamate
AMPa- perampanel, telampanel
Kainate- phenobarbitone, topiramate

86
Q

K ch openers

A

Ezogabine- retigasine

87
Q

Tt of psychosis

A

Atypical anti psych- Aripirazole
Ziprasidone, quetiapine

Another atypical

Typical

Resistant- clozapine

Ect

88
Q

Doc for intractable hiccups

A

Chlorpromazine

89
Q

Atypical antipsych

A

Clozapine
Olanzapine
Zotepine
Asenapine
Quetiapine

Ziprasidone
Risperidone
Ilaperidone

90
Q

D1, D2 partial agonist - 5 HT 2A antag

A

Aripiprazole
Prexipiprazole

91
Q

D2 + D3 antag

A

Sulpiride
Levosulpiride

92
Q

5 HT2 A inverse agonist

A

Pimavanserin

93
Q

A/E of anti psych

A

Never APART
neurolept malignant synd
Acute muscle dystonia
Parkinsonism
Akathesia
Rabbit syndrome
Tardive dyskinesia

94
Q

Anti depressants

A

Reuptake inhibitors- SSRI, SNRI, NRI, TCA
Mao inhibitors
Atypical antidepressants

95
Q

Ssris

A

FFP DECS
fluoxetine
Flunoxamine
Paroxetine
Dapoxetine
Escitalopram
Citalopram
Sertaline

96
Q

Side effects of ssris

A

Seizure
Sexual dysfunction
Suicides
Serotonin syndrome
Severe anxiety
Siadh

97
Q

Snris

A

Very diff MD
Venlafaxine
Desvenlafaxine
Milnacipram
Duloxetine

98
Q

Nris

A

Atomoxetine

99
Q

Tca

A

-Ne= ser
ITC DAD-
Imipramine
Trimipramine
Clomipramine
Doxepin
Amitryptiline
Dothepin

  • Ne>ser
    RONA- Reboxetine
    Desimipramine
    Nortryptiline
    Amoxapine
100
Q

Uses of tca

A

Denims- depression
Enuresis
Neuropathic pain
Migraine
Smoking

101
Q

Antidote for tca poisoning

A

NahCo3 + lignocaine

102
Q

Mao inhibitors

A

Non selective- phenelzine, nialamide
Rev MAO A- clorygine, maclobenide
Sel mAO B - seligiline, rasigiline

103
Q

Atypical anti depressants

A

Bupropion
Buspirone
Trazodone
Mianserin

Pharmacology (18 decks)

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