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Cns Flashcards

1
Q

Doc for primary parkinsonism

A

Levodopa

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2
Q

On off effect seen in

A

Late parkinsonism

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3
Q

Mao B inhibitors in parkinsonism

A

Irrev- Seligilline
Rasagilline
Rev- safinamide

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4
Q

COMT inhibitors- catechol O methyl transferase

A

Tone-
Entacapone
Nitecapone
Opicapone
Tolcapone

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5
Q

Nmda antags in parkinson

A

Amantadine

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6
Q

Dopamine agonists

A

Ergots-
Bromocriptine
Cabergoline

Non ergots- PRA
Pramipexole
Ropinrole
Rotigotine
Apomorphine

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7
Q

Management of parkinsonism

A

No funcctional impairment- rasigiline
Func imp- levodopa
To reduce periph S/E- add bensarazide + Amantadine
Prolong on- Entacapone
Rescue off- Apomorphine
Vomiting - donperidone
Psychosis- clozapine, quetiapine, pimavanserin
Resting tremors- Benzhexol, promethazine

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8
Q

Doc for drug induced parkinsonism

A

Bbb
Benzhexol
Benztropin
Biperiden

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9
Q

Doc for intermittent restless leg synd

A

Levodopa
Carbidopa

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10
Q

Chronic resltlesd leg synd doc

A

Pregabalin
Gabapentin
Ropinrole
Pramipexole

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11
Q

Doc in huntingtons

A

Dopamine depletors- VMAT 2 inhibitors-
Tetrabenazine
Deutetrabenazine
Valbenazine

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12
Q

Doc for rheumatic chores- sydenham’s chorea

A

Valproate or carbamazapine- prednisolone

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13
Q

Doc for tourette syn

A

Guanephecine, clonidine- atypical anti psych- typical anti psych
If adhd + tourette- Atomoxetine

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14
Q

Doc for Wilson’s ds

A

Zn - dec absorption of cu in gjt
Liver damage - trientene - penicillamine- liver ts
Cns- tetrathiomolybdate

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15
Q

ALS doc

A

Neuroprotectives - Riluzole
Edaraxone
Muscle relaxants
Anticholinergics
Dexomethophan, quinidine

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16
Q

Progeria doc

A

Lonafarnib

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17
Q

Acute attack Multiple sclerosis doc

A

Methyl prednisolone

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18
Q

For long term MS DOC

A

Rrms- interferon beta
Spms- mitoxantone
Ppms- ocrelizumab

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19
Q

Dis modifying drugs for MS

A

Go find dat cm
Glatimeracetate
Ocrelizumab
Fingolimod
Inf beta
Natalizumab
Dimethyl fumarate
Daclizumab
Alemtuzumab
Terflunomide
Cladribine
Mitoxantrone

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20
Q

Sedatives nd hypnotics

A

Barbiturates
Bzd
Atypical bzd
Melatonin
Alchohols
Opiods
Anti histamines
Tca

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21
Q

Antidote for bzd

A

Flumazenil

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22
Q

Ultra short acting barbiturates

A

Thiopentone
Methohexitone

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23
Q

Doc for ect

A

Methohexitone

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24
Q

Short acting barbiturates

A

Butabarbitone
Amobarbitone
Pentabarbitone
Secobarbitone

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25
Long acting barbiturates
Phenobarbitone Primidone
26
Doc for neonatal jaundice
Phenobarbitone
27
Bzds
Anti seizures- diazepam Lorazepam Clonazepam Clobazepam Midazolam Pre anaesthetic- diazepam Lorazepam Midazolam Remimazolam Insomnia- flurazepam Temazepam Estazolam Quazepam Anti anxiety- diazepam Clonazepam Oxazepam Lorazepam Muscle Relaxants- diazepam Baclofen
28
Acute attack of anxiety doc
Propanolol
29
Bzd safe in liver ds
Lorazepam Oxazepam Temazepam Estazolam
30
Longest acting bzd
Flurazepam
31
Date rape drugs
AK Bas GF Alchohol Ketamine Barbiturates Gamma hydroxybutyrate Flunitrazepam- roofie
32
Drugs for insomnia
Barbiturates- inc NREM Atypical Bzd Melatonin
33
Atypical bzd
Z drugs Zopiclone Zopidem Zaleplon
34
Melatonin analogs
Ramelteon- jet lag Tasimelteon- blind ppl circadian rhythm
35
Drug inhibiting alchohol dehydrogenase
Fomepizole
36
Drug inhibiting aldehyde dehydrogenase
Disulfiram
37
T/t of alchohol poisoning
Shafe Sodium bicarbonate Hemodialysis Antidote- fomepizole Folic acid Ethanol
38
Addiction syndrome
Acute withdrawal syndrome- delirium, tremors, korsakoff psychosis
39
Detoxification of alchohol, maintainance phase doc
Chlordiazepoxide
40
Anti craving for alchohol
Oral naltrexone+ acamprosate
41
Deterrent for alchohol
Disulfiram
42
Disulfiram reaction
Flushing, abd pain, nausea, headache, hypotension
43
Drugs showing disulfiram like reaction
CGMP- Chlorpropamide Griseofulvin Metronidazole Procarbazine
44
Natural opiods
Analgesic- morphine, codeine Non analgesic- papaverine, noscapine, thebaine
45
Effect of u receptor
Sacrum no gap Sedation Analgesic Constipation, cough Resp depression Euphoria Miosis Nausea vomiting Gall stones Abdominal colic PRL release
46
Least potent opiod
Codeine
47
Opiods as antitussives
Codeine Hydocodone Oxycodone Morphine Hydromorphone Oxymorphone
48
Non addictive anti tussives
Dectromethorpham Noscapine
49
Doc for opiods in preg Doc for post anesthetic shivering
Pethidine
50
Doc of day care surgery
Remifentanyl- shortest opioid
51
Neurolept analgesic
Fentanyl + droperidol
52
Doc in opiod deaddiction
Methadone- longest opioid
53
Mixed acting opiods- partial kappa agonist nd u antag
PNB pentazocine Nalbuphine Butarphanol
54
Pure kappa agonist
Nalfurafine Eluxlodine Asimadoline
55
Partial u agonist nd kappa antag
Buprenorphine Dezocine
56
Pure antags of all all opiod receptors
Naloxone Naltrexone Nalmeftane
57
Opiod addiction tt
Acute overdose- naloxone Maintenance- BMT buprenorphine, methadone, tramadol
58
Morphine nd congeners- u agonist
Morphine Codeine Fentanyl Remifentanyl Pethidine Methadone Tramadol
59
Mood stabilisers
Low VOLTAGE lithium Valproate Oxcarbazepine Lamotrigin2 Topiramate Anti psych Gabapentin
60
Acute mania doc
Lithium Anti psych Valproate
61
Doc rapid cycling Bipolar ds
Valproate
62
Maintenance of bipolar ds
Oral lithium
63
Lithium uses
BHAR bipolar ds Hypnic headache Anti suicidal Resting depression
64
Adverse effects of lithium
LITHIUMS Leucocytosis Inc wt, thirst Tremors Hypothyroidism Inc nausea, vomiting, diarrhea Urination Mental seizures Skin
65
Ecg changes caused by lithium
Flattening of t wave Increase PR interval
66
Lithium in preg causes
Ebstein anomaly Goitre Hypotonia- floppy baby
67
Types of epilepsy
Generalised- GTCS, Absence, atypical absent seizures Focal
68
First line drugs for generalised seizures
GTCS- lamptrigine, valproate Ab seizure- lamotrigine, valproate, ethosuximide
69
2nd line druga for gen seizures
Gtcs- many Ab seizure- clonazepam, zonazepam, levitiracetam
70
Focal seizures 1st line
LoC pl Lamotriginw Oxcarbamazepine Carbamazepine Phenytoin Levetiracetam
71
Lennox gestatt syndrome
Doc valproate-- clobazam-- rufinamide--- fenoldapam
72
Dravel's syndrome- severe myoclonal epilepsy of infancy
Valproate-- clobazam-- stiripentol
73
Doc for infantile spasm
Vigabatrin
74
Doc for febrile seizures
Rectal diazepam
75
Epilepsy in preg
If already epileptic - in preg- add folic acid- 4000 mg Vit K 10mg If planning- stop Aed- start levetiracetam, lamotrigine
76
Status epilepticus
5-10min- lorazepam, clonazepam, midazolam 30 min- midazolam, propofol I/v phenobarbitone 48 hrs- lobectomy, hypothermia Isoflurane, desflurane, ketamine
77
Classification of AED
Na ch blockers Ca ch blockers Cl ch openers K efflux Glu rls inhibitors Glu receptor blockers
78
Na ch blockers
PCV ToLL Phenytoin Carbamazepine Valproate Topiramate Lamotrigine Lacosamide
79
Phenytoin side effects
CCC cerebellar toxicity Cerebral toxicity Cardiac arrythmias Hyperplasia of gums Hirsutism Heavy wt- obesity Hyperglycemia Hypersensitivity Hampers vit absorption Hodgkin like pseudolymphoma Hydantoin synd
80
Carbamazepine s/e
Shades Steven johnson Hepatotoxic Aplastic anemia Diplopia Esoniophilia Siadh
81
Ca ch blockers
VELT valproate Ethosuximide Lamotrigine Trimethadine
82
Valproate side effects
VALPROATE Vomiting Alopecia Liver toxicity Pancreatitis Rashes Obesity Amm level inc Tremors Enz inhibitor
83
Druga promoting gaba - A Cl ch
Barbiturates- phenobarbitone, mephobarbitone, stiripentol Bzd- diazepam, lorazepam, clonazepam, clobazam, midazolam Pregabalin, gabapentin Tigabine Vigabatrin
84
Drugs inhibiting glutamate rls
Levetiracetam Brivaracetam
85
Drugs blocking glu receptor
Nmda- Felbamate AMPa- perampanel, telampanel Kainate- phenobarbitone, topiramate
86
K ch openers
Ezogabine- retigasine
87
Tt of psychosis
Atypical anti psych- Aripirazole Ziprasidone, quetiapine Another atypical Typical Resistant- clozapine Ect
88
Doc for intractable hiccups
Chlorpromazine
89
Atypical antipsych
Clozapine Olanzapine Zotepine Asenapine Quetiapine Ziprasidone Risperidone Ilaperidone
90
D1, D2 partial agonist - 5 HT 2A antag
Aripiprazole Prexipiprazole
91
D2 + D3 antag
Sulpiride Levosulpiride
92
5 HT2 A inverse agonist
Pimavanserin
93
A/E of anti psych
Never APART neurolept malignant synd Acute muscle dystonia Parkinsonism Akathesia Rabbit syndrome Tardive dyskinesia
94
Anti depressants
Reuptake inhibitors- SSRI, SNRI, NRI, TCA Mao inhibitors Atypical antidepressants
95
Ssris
FFP DECS fluoxetine Flunoxamine Paroxetine Dapoxetine Escitalopram Citalopram Sertaline
96
Side effects of ssris
Seizure Sexual dysfunction Suicides Serotonin syndrome Severe anxiety Siadh
97
Snris
Very diff MD Venlafaxine Desvenlafaxine Milnacipram Duloxetine
98
Nris
Atomoxetine
99
Tca
-Ne= ser ITC DAD- Imipramine Trimipramine Clomipramine Doxepin Amitryptiline Dothepin - Ne>ser RONA- Reboxetine Desimipramine Nortryptiline Amoxapine
100
Uses of tca
Denims- depression Enuresis Neuropathic pain Migraine Smoking
101
Antidote for tca poisoning
NahCo3 + lignocaine
102
Mao inhibitors
Non selective- phenelzine, nialamide Rev MAO A- clorygine, maclobenide Sel mAO B - seligiline, rasigiline
103
Atypical anti depressants
Bupropion Buspirone Trazodone Mianserin

Pharmacology (18 decks)

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