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Pharmacology > Anti Cancer > Flashcards

Anti Cancer Flashcards

1
Q

Common S/E of cytotoxic cancer drugs

A

BM supression
Alopecia
Mucositis
Hyperuricemia
Nausea and vomiting

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2
Q

Cytotoxic drugs

A

Alkylating agents
Platinum compounds
Antimetabolites
Drugs acting on mitotic spindle
Topoisomerase inhibitors
Misc drugs

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3
Q

Alkylating agent drugs

A

If bus not present take my cycle
Ifosfamide
Busulfan
Nitrosoureas- carmistine, lamustine, semustine
Procarbazine
Temozolomide
Melphalan, mitomycin C
Cyclophosphamide

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4
Q

Doc for gliomas

A

Temozolomide

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5
Q

Drugs causing pulmonary fibrosis

A

Cyclophosphamide
Carmustine
Busulphan
Amiodarone
Bleomycin

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6
Q

Platinum drugs

A

Cisplatin
Carboplatin
Oxaliplatin

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7
Q

Colorectal carcinoma doc

A

Oxaliplatin

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8
Q

Drugs affecting folic acid syn

A

Methotrexate
Pralatrexate
Permetrexed

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9
Q

Uses of methotrexate

A

Cancer
Choriocarcinoma
All, aml
Nhl
Crohn ds
Ectopic pregnancy
Rheumatoid arthritis

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10
Q

Adverse effects of methotrexate

A

Bm suppresion
Alopecia, hyperuricemia, diarrhea,
Inhibits folic acid- megaloblastic anemia

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11
Q

Antidote of methotrexate poisoning

A

Folinic acid- leucovorin or citrovorum

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12
Q

Drugs affecting purine syn

A

6 mercaptopurine
6 thioguanine
Cladribine
Fludarabine

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13
Q

Doc for hairy cell leukemias

A

Cladribine

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14
Q

Doc for cll

A

Fludarabine

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15
Q

Drugs affecting pyrimidine metabolism

A

5 flurouracil
Gemicitabine
Cytarabine
Capecitabine

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16
Q

Doc for panc cancer

A

Gemicitabine

17
Q

Side effects of 5 flurouracil

A

Causes hand and foot syndrome

18
Q

Drugs acting on mitotic spindle

A

Spindle formation inhibitors - vinca alkaloids
Vincristine
Vinblastine

Spindle breakdown inhibitors- taxels
Paclitaxel

19
Q

Topoisomerase inhibitors

A

1 - irinotecan

2 inhibitor- etoposide
Anthracyclines
Doxorubicin
Donorubicin
Epirubicin

20
Q

Misc drugs

A

Bleomycin- marrow sparing
L asparaginase
AS2Q3
Thalidomide

21
Q

Targeted anti cancer drugs

A

Tyrosine kinase inhibitors
Proteasome inhibitors
Parp inhibitors
Cyclin dependent kinase inhibitors
Monoclonal antibodies

22
Q

Doc for cml

A

Imatinib

23
Q

Important tyrosine kinase inhibitors

A

For cml- imatinib
Nilotinib
Dasatinib

For lung cancer- afatinib
Erlotinib

For renal cancer- pazopanib
Sunitinib

For gist- sunitinib
Imatinif
Regorafarib

Breast- lapatinib
Neratinib

24
Q

Proteazome inhibitors - zombi drugs

A

Bortezomib
Carfilzomib
Ixazomib

25
Q

Parp inhibitors

A

Olaparib

26
Q

Cdki

A

Palbociclib
Ribociclib

27
Q

Monoclonal ab

A

Rituximab
Cetuximab
Trastuzumab
Pertuzumab

Pharmacology (18 decks)

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