Anti Cancer

Question 1

Common S/E of cytotoxic cancer drugs

Answer 1

BM supression
Alopecia
Mucositis
Hyperuricemia
Nausea and vomiting

Question 2

Cytotoxic drugs

Answer 2

Alkylating agents
Platinum compounds
Antimetabolites
Drugs acting on mitotic spindle
Topoisomerase inhibitors
Misc drugs

Question 3

Alkylating agent drugs

Answer 3

If bus not present take my cycle
Ifosfamide
Busulfan
Nitrosoureas- carmistine, lamustine, semustine
Procarbazine
Temozolomide
Melphalan, mitomycin C
Cyclophosphamide

Question 4

Doc for gliomas

Answer 4

Temozolomide

Question 5

Drugs causing pulmonary fibrosis

Answer 5

Cyclophosphamide
Carmustine
Busulphan
Amiodarone
Bleomycin

Question 6

Platinum drugs

Answer 6

Cisplatin
Carboplatin
Oxaliplatin

Question 7

Colorectal carcinoma doc

Answer 7

Oxaliplatin

Question 8

Drugs affecting folic acid syn

Answer 8

Methotrexate
Pralatrexate
Permetrexed

Question 9

Uses of methotrexate

Answer 9

Cancer
Choriocarcinoma
All, aml
Nhl
Crohn ds
Ectopic pregnancy
Rheumatoid arthritis

Question 10

Adverse effects of methotrexate

Answer 10

Bm suppresion
Alopecia, hyperuricemia, diarrhea,
Inhibits folic acid- megaloblastic anemia

Question 11

Antidote of methotrexate poisoning

Answer 11

Folinic acid- leucovorin or citrovorum

Question 12

Drugs affecting purine syn

Answer 12

6 mercaptopurine
6 thioguanine
Cladribine
Fludarabine

Question 13

Doc for hairy cell leukemias

Answer 13

Cladribine

Question 14

Doc for cll

Answer 14

Fludarabine

Question 15

Drugs affecting pyrimidine metabolism

Answer 15

5 flurouracil
Gemicitabine
Cytarabine
Capecitabine

Question 16

Doc for panc cancer

Answer 16

Gemicitabine

Question 17

Side effects of 5 flurouracil

Answer 17

Causes hand and foot syndrome

Question 18

Drugs acting on mitotic spindle

Answer 18

Spindle formation inhibitors - vinca alkaloids
Vincristine
Vinblastine

Spindle breakdown inhibitors- taxels
Paclitaxel

Question 19

Topoisomerase inhibitors

Answer 19

1 - irinotecan

2 inhibitor- etoposide
Anthracyclines
Doxorubicin
Donorubicin
Epirubicin

Question 20

Misc drugs

Answer 20

Bleomycin- marrow sparing
L asparaginase
AS2Q3
Thalidomide

Question 21

Targeted anti cancer drugs

Answer 21

Tyrosine kinase inhibitors
Proteasome inhibitors
Parp inhibitors
Cyclin dependent kinase inhibitors
Monoclonal antibodies

Question 22

Doc for cml

Answer 22

Imatinib

Question 23

Important tyrosine kinase inhibitors

Answer 23

For cml- imatinib
Nilotinib
Dasatinib

For lung cancer- afatinib
Erlotinib

For renal cancer- pazopanib
Sunitinib

For gist- sunitinib
Imatinif
Regorafarib

Breast- lapatinib
Neratinib

Question 24

Proteazome inhibitors - zombi drugs

Answer 24

Bortezomib
Carfilzomib
Ixazomib

Question 25

Parp inhibitors

Answer 25

Olaparib

Question 26

Cdki

Answer 26

Palbociclib Ribociclib

Question 27

Monoclonal ab

Answer 27

Rituximab Cetuximab Trastuzumab Pertuzumab