Autacoids Flashcards by Umama Unknown

Broad classification of autacoids

Peptide
Amine
Lipid
Gas

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Histidine undergoes what to form histamine

Decarboxylation

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Degradation of histamine occurs by

MAO A enzyme

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Receptors of histamine and their types

H1- Gq
H2- Gs
H3-Gi
H4-Gi

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First gen H1 antags are also

Non specific muscarinic blockers- posess anti cholinergic props
Parkinsonism, akathesia, common cold, prophylaxis of motion sickness

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Most sedative, local anaesthetic anti histamine

Promethazine

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DOC for tt of motion sickness

Promethazine

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Doc for tt of drug induced parkinsonism

Promethazine

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Longest acting anti histaminic

Hydroxyzine

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Doc for 1st trimester morning sickness

Doxylamine

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Drugs effective in sea sickness

Cyclizine, meclizine, cinnarizine

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AVil is

Pheniramine

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Least sedative anti histaminic approved for day time

Chlorpheniramine

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Terfinadine and astemizole if combined with erythromycin causes

Increased qt int- Torsades pointes

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Topical 2nd gen anti histaminics

A Azelastine
L levocarbastine
O Olopatidine
K Ketotifen
A Alcaftadine

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H2 blocker- max cyp inhibitor

Cimetidine

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H3 agonists

Pitolisant tiprolisant

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Doc for narcolepsy

Modafinil

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3rd gen antihistaminics

Desloratidine
Levocetrizine
Fexofenadine

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Drug inhibiting trp hydroxylase

Telotristat

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Which receptor of serotonin is not GPCR

5HT3- ipnotropic

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5HT 1A AGONIST

Anti anxiety-
Buspirone
Gepirone

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5HT1 A, 5HT 1 D Agonist

Triptans
Ergotamine

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Doc for acute migraine

Triptans

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5HT 1 F agonist

Lasmiditan

Triptan given by all routes

Sumatriptan

Most effective

Eletriptan

Fastest triptan

Rizatriptan

Longest triptan

Frovatriptan

Inflammation in migraine is caused by

CGRP- 2 Calcitonin gene rltd peptide

Why should triptans and ergotamine never be combined

HERD- hypertension, coronary vasospasm, erythromealgia, raynaud's disease, dry gangrene of fingers

Methylsergide is banned cause

Retroperitoneal fibrosis

5ht 2c agonist

Lorcaserin

5ht 2 - ABC antags

Olanzapine, clozapine

5ht2 to 5ht 4 antags

Anti serotonin - kitanserin, ritanserin , cyproheptadine

Doc for serotonin syndrome

Cyproheptadine

5 ht 3 antags antimotility

Alosetron

5 ht3 antags anti emetics

Got pr granisetron Ondensetron Tropisetron Palonosetron Ramosetron

5 ht 4 agonist

CM trip- cisapride Mosapride Tegaserod Renzapride Itopride Prucalopride

D2 antags

Domperidone

Drug induced parkinsonism caused by

Metoclopramide

Doc for mild acute migraine

Nsaids + caffeine

Acute migraine with AURA

Domeperidone

In pregnancy migraine

Pcm given

Prophylaxis in chr migraine

BACTAMS- Beta blockers- propolol, timolol Anti epileptics- valproate, topiramate Ca ch blockers- verapamil Tca- imiflamine Anti serotonin- ketanserin, ritanserin, cyproheptidine Moa-tor-- phenelzine

Cgrp 2 oral antags

RAT rimegepant Atogepant Telcagepant

Iv cgrp2 inhibitor

EFG- erenumab, fremanezumab, galcanezumab

Doc for closure of ductus ateriosus

Ibuprofen

Open ductus arteriosus doc

Alprostadil

Samtar's triad

Aspirin + asthma+ ethmoidal polyp

Reye syndrome

Aspirin+ viral fever + children= fulminant hepatic fever

Salicyclism antidote

Na bicarbonate, hemodialysis

Non selective COX inhibitor

I M PiNK Indomethacin Mefenamic acid Phenylbutazone Ibuprofen Piroxicam Naproxen Ketkrolac

Doc for menstrual pain

Mefenamic acid

Preferential COX 2 inhibitor

MADE Meloxicam Aceclofenac Diclofenac Etodolac

Selective COX inhibitor

COXIBS Rofevoxib Valdecoxib Lumiracoxib Etaricoxib Parecoxib Celecoxib

Acute gout tt

Nsaids Colchicine Corticosteroids

Colchicine moa

Microtububule inhibitor- inhibit migration of wbcs- no rls of inf mediators

Chronic gout tt

Xanthine oxidase inhibitor Uric acid oxidase Uricosuric agents

Doc for gout

Allopurinol

Xanthine oxidase inhibitors

Allopurinol Febuxostat Oxypurinol

Uric acid oxidase

Rasberry paglet Rasburicase Pegloticase

Uricosuric agents

Bpl Benzbromarone Probenecid Lesinurad

S/e of allopurinol

Hs reaction Bm suppression Hepatotoxicity

Drugs causing gout

Pained Pyrazinamide Aspirin Immunosuppressant Niacin Ethambutol Diuretics

Rheumatoid tt

Acute- nsaids, corticosteroids Chronic- dmaards or saards

Dmaards- conventional

Mallika sherawat pagal c Methotrexate Sulfasalazine Penicillamine Azathioprine Gold Leflunomide Chloroquine

Safest dmaard in preg

Hydroxychloroquine

Biologics anti rheumatic

Anti tnf alpha- ice age Inflixumab Certolizumab Etanercept Adalimumab Golimumab Anti il 6- sarilumab Anti cd 20- rituximab Anti il1- anakinra Anti jak- upapacitinib, basicitinib

Pge1

Misoprostol Luniprostone Alprostadil Gemeprost

Misoprostol in preg causes

Mobius synd- abnormal facies