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Pharmacology > Autacoids > Flashcards

Autacoids Flashcards

1
Q

Broad classification of autacoids

A

Peptide
Amine
Lipid
Gas

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2
Q

Histidine undergoes what to form histamine

A

Decarboxylation

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3
Q

Degradation of histamine occurs by

A

MAO A enzyme

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4
Q

Receptors of histamine and their types

A

H1- Gq
H2- Gs
H3-Gi
H4-Gi

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5
Q

First gen H1 antags are also

A

Non specific muscarinic blockers- posess anti cholinergic props
Parkinsonism, akathesia, common cold, prophylaxis of motion sickness

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6
Q

Most sedative, local anaesthetic anti histamine

A

Promethazine

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7
Q

DOC for tt of motion sickness

A

Promethazine

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8
Q

Doc for tt of drug induced parkinsonism

A

Promethazine

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9
Q

Longest acting anti histaminic

A

Hydroxyzine

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10
Q

Doc for 1st trimester morning sickness

A

Doxylamine

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11
Q

Drugs effective in sea sickness

A

Cyclizine, meclizine, cinnarizine

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12
Q

AVil is

A

Pheniramine

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13
Q

Least sedative anti histaminic approved for day time

A

Chlorpheniramine

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14
Q

Terfinadine and astemizole if combined with erythromycin causes

A

Increased qt int- Torsades pointes

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15
Q

Topical 2nd gen anti histaminics

A

A Azelastine
L levocarbastine
O Olopatidine
K Ketotifen
A Alcaftadine

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16
Q

H2 blocker- max cyp inhibitor

A

Cimetidine

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17
Q

H3 agonists

A

Pitolisant tiprolisant

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18
Q

Doc for narcolepsy

A

Modafinil

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19
Q

3rd gen antihistaminics

A

Desloratidine
Levocetrizine
Fexofenadine

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20
Q

Drug inhibiting trp hydroxylase

A

Telotristat

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21
Q

Which receptor of serotonin is not GPCR

A

5HT3- ipnotropic

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22
Q

5HT 1A AGONIST

A

Anti anxiety-
Buspirone
Gepirone

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23
Q

5HT1 A, 5HT 1 D Agonist

A

Triptans
Ergotamine

24
Q

Doc for acute migraine

A

Triptans

25
Q

5HT 1 F agonist

A

Lasmiditan

26
Q

Triptan given by all routes

A

Sumatriptan

27
Q

Most effective

A

Eletriptan

28
Q

Fastest triptan

A

Rizatriptan

29
Q

Longest triptan

A

Frovatriptan

30
Q

Inflammation in migraine is caused by

A

CGRP- 2 Calcitonin gene rltd peptide

31
Q

Why should triptans and ergotamine never be combined

A

HERD- hypertension, coronary vasospasm, erythromealgia, raynaud’s disease, dry gangrene of fingers

32
Q

Methylsergide is banned cause

A

Retroperitoneal fibrosis

33
Q

5ht 2c agonist

A

Lorcaserin

34
Q

5ht 2 - ABC antags

A

Olanzapine, clozapine

35
Q

5ht2 to 5ht 4 antags

A

Anti serotonin - kitanserin, ritanserin , cyproheptadine

36
Q

Doc for serotonin syndrome

A

Cyproheptadine

37
Q

5 ht 3 antags antimotility

A

Alosetron

38
Q

5 ht3 antags anti emetics

A

Got pr granisetron
Ondensetron
Tropisetron
Palonosetron
Ramosetron

39
Q

5 ht 4 agonist

A

CM trip- cisapride
Mosapride
Tegaserod
Renzapride
Itopride
Prucalopride

40
Q

D2 antags

A

Domperidone

41
Q

Drug induced parkinsonism caused by

A

Metoclopramide

42
Q

Doc for mild acute migraine

A

Nsaids + caffeine

43
Q

Acute migraine with AURA

A

Domeperidone

44
Q

In pregnancy migraine

A

Pcm given

45
Q

Prophylaxis in chr migraine

A

BACTAMS- Beta blockers- propolol, timolol
Anti epileptics- valproate, topiramate
Ca ch blockers- verapamil
Tca- imiflamine
Anti serotonin- ketanserin, ritanserin, cyproheptidine
Moa-tor– phenelzine

46
Q

Cgrp 2 oral antags

A

RAT rimegepant
Atogepant
Telcagepant

47
Q

Iv cgrp2 inhibitor

A

EFG- erenumab, fremanezumab, galcanezumab

48
Q

Doc for closure of ductus ateriosus

A

Ibuprofen

49
Q

Open ductus arteriosus doc

A

Alprostadil

50
Q

Samtar’s triad

A

Aspirin + asthma+ ethmoidal polyp

51
Q

Reye syndrome

A

Aspirin+ viral fever + children= fulminant hepatic fever

52
Q

Salicyclism antidote

A

Na bicarbonate, hemodialysis

53
Q

Non selective COX inhibitor

A

I M PiNK
Indomethacin

Mefenamic acid
Phenylbutazone
Ibuprofen
Piroxicam
Naproxen
Ketkrolac

54
Q

Doc for menstrual pain

A

Mefenamic acid

55
Q

Preferential COX 2 inhibitor

A

MADE
Meloxicam
Aceclofenac
Diclofenac
Etodolac

56
Q

Selective COX inhibitor

A

COXIBS
Rofevoxib
Valdecoxib
Lumiracoxib
Etaricoxib
Parecoxib
Celecoxib

Pharmacology (8 decks)

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