chronic conditions 2.3

Question 1

what is pernicous anemia?

Answer 1

a deficency of intrinsic facotr which causes a malabsoprtion of vitamin b12

Question 2

what is anemia of chronic disease?

Answer 2

anemia chaused by chronic inflammation due to infections, autoimmune disease or chronic cancer

Question 3

how does chronic infflamation cause anemia of chronic disease?

Answer 3

the infflamation produces reactive proteins that lock iron away in macrophages in the bone marrow prefenting it from being used during red blood cell production

Question 4

why does the reactive proteins lock iron away in the macrophages during chronic infflamation?

Answer 4

because iron is essential for pathogen replication so the body does this to inhibit pathogen development

Question 5

what is sideroblastic anemia?

Answer 5

defective protoporphyrin production which impairs heme synthesis

Question 6

what is the cause of sideroblastic anemia?

Answer 6

vitamin b6 deficiency
lead poisoning

Question 7

what is thalassemia?

Answer 7

a genetic disorder causing a decrease in globin chains which is a component in hemoglobin

Question 8

what can trigger sickling events

Answer 8

• hypoxia
• dehydration
• acidosis
• stress (cold exposure, illness, exercise)

Question 9

what is aplastic anemia?

Answer 9

failure of the hematopoietic stem cells in the bone marrow to produce blood cells

Question 10

what is hypothyroidism?

Answer 10

an underactive thyroid gland which causes a decrease in t3/t4 hormones