Chapter 7: Cell Membrane (Test 2) Flashcards
Phospholipids are the most abundant lipid in the plasma membrane
Phospholipids are ___ molecules, containing hydrophobic and hydrophilic regions
The fluid mosaic model states that a membrane is a fluid structure with a “mosaic” of various proteins embedded in it
amphipathic
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___ studies of the plasma membrane supported the fluid mosaic model
Freeze-fracture is a specialized preparation technique that splits a membrane along the middle of the phospholipid bilayer
Freeze-fracture
Phospholipids in the plasma membrane can move within the bilayer
Most of the phospholipids drift laterally, but rarely does a molecule flip-flop transversely across the membrane
Some proteins drift within the phospholipid bilayer
Other proteins never move and are anchored to the cytoskeleton below
As temperatures cool, membranes switch from a fluid state to a solid state
Components of membrane types of lipids
Membranes rich in unsaturated fatty acids are more fluid that those rich in saturated fatty acids
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Cholesterol acts as a “temperature buffer” for the membrane
At warm temperatures (such as 37°C), cholesterol restrains movement of phospholipids
At cool temperatures, it maintains fluidity by preventing tight packing
___ proteins penetrate the hydrophobic core
___ proteins are bound to the surface of the membrane
Integral
Peripheral
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Six major functions of membrane proteins:
- Transport
- Enzymatic activity
- Signal transduction
- Cell-cell recognition
- Intercellular joining
- Attachment to the cytoskeleton and extracellular matrix (ECM)
___ molecules, such as hydrocarbons, can dissolve in the lipid bilayer and pass through the membrane rapidly
___ molecules, such as sugars and ions do not cross the membrane easily
Hydrophobic (nonpolar)
Hydrophilic (polar)
___ is the tendency for molecules to spread out evenly. (molecules move from areas of higher to lower concentration)
Although each molecule moves randomly, diffusion of a population of molecules may exhibit a net movement in one direction
At ___ , as many molecules cross one way as cross in the other direction
Diffusion
dynamic equilibrium
Substances diffuse down their ___, the difference in concentration of a substance from one area to another
No work must be done to move substances down the concentration gradient
The diffusion of a substance across a biological membrane is ___ because it requires no energy from the cell to make it happen
concentration gradient
passive transport
___ is the diffusion of water across a selectively permeable membrane
Water diffuses across a membrane from the region of lower solute(higher water molecules) concentration to the region of higher solute (lower water molecules) concentration
Osmosis
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___ is the ability of a solution to cause a cell to gain or lose water
Tonicity
___: Solute concentration is less than that inside the cell; cell gains water
Hypotonic solution
___: Solute concentration is the same as that inside the cell; no net water movement across the plasma membrane
Isotonic solution
___: Solute concentration is greater than that inside the cell; cell loses water
Hypertonic solution
Hypertonic or hypotonic environments create challenges for organisms
___, the control of water balance, is a necessary adaptation for life in such environments
Osmoregulation
In ___, transport proteins speed the passive movement of molecules across the plasma membrane
facilitated diffusion
___ allow passage of hydrophilic substances across the membrane
___ provide corridors that allow a specific molecule or ion to cross the membrane
- Aquaporins- for facilitated diffusion of water
- Ion channels- open or close in response to a stimulus (gated channels)
Transport proteins
Channel proteins
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___ undergo a subtle change in shape that translocates the solute-binding site across the membrane
Carrier proteins
___ moves substances against their concentration gradient
Active transport requires energy, usually in the form of ATP
Active transport is performed by specific proteins embedded in the membranes
Active transport
Active transport allows cells to maintain concentration gradients that differ from their surroundings
The ___ is one type of active transport system
sodium-potassium pump
Large molecules, such as polysaccharides and proteins cross the membrane in bulk via packaging in vesicles
Bulk transport requires energy
In ___, transport vesicles migrate to the membrane, fuse with it, and release their contents out of cell
Many secretory cells (like those in the pancreas secreting insulin) use exocytosis to export their products
exocytosis
In ___, the cell takes in macromolecules by forming vesicles from the plasma membrane
Endocytosis is a reversal of exocytosis, involving different proteins
There are three types of endocytosis:
Phagocytosis (“cellular eating”)
Pinocytosis (“cellular drinking”)
Receptor-mediated endocytosis
endocytosis
In ___ a cell engulfs a particle in a food vacuole
The vacuole fuses with a lysosome to digest the particle
phagocytosis
In ___, molecules are taken up when extracellular fluid is “gulped” into tiny vesicles
pinocytosis
In receptor-mediated endocytosis, vesicle formation is triggered by signals from outside the cell that bind to receptors on plasma membrane
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