Chapter 40: The Immune System And Disease Flashcards
Disease
Anything that damages or disrupts the body negatively
Louis Pasteur and Robert coch
Came up with the concept of germ theory of disease by using microscopes
5 types of pathogens
Bacteria Viruses Mold/fungus Parasite Prions
Cochs postulates
- A pathogen is always found in the body of a sick person, but not in healthy people
- A pathogen must be isolated and grown in a pure culture
- Cultures pathogens and places in a healthy animal. It’ should cause the same disease that the original pathogen did
- The injected pathogen should be isolated from the second host (grow the bacteria to double check if it’s identical to the original pathogen)
Bacteria
Mostly harmless, need food right temperature and good environment to grow
Viruses
Tiny particles that aren’t alive. When they replicate in a cell the cell bursts and kills it
Types of bacteria
Enterotoxins
Neurotoxins
Enterotoxins
Dangerous bacteria that kill neighboring cells. An example would be staphylococcus aureus. It releases a chemical that destroys cells. A strain of this is methicillin resistant staphylococcus aureus (MRSA). Can be deadly if the doctors can’t stop the infection.
Neurotoxins
Get in blood and destroy synapses. An example is clostridium tetani you get it when u step on something rusty bc an abases forms and releases the neurotoxin. (When metal rusts it rusts in layers. In between the layers is an anerobic environment where bacteria can grow )
Facultative anaerobes
Bacteria that can survive in the presence of oxygen but prefer no oxygen
Protists
Multicellular pathogens that Incase red blood cells and reproduce inside them. The cells burst and the protists are released into the blood stream and make u very sick
Tympanosomes
Worms that live in the bloodstream of vertebrate animals
Ascaris
Tympanosome (round worm) that live in instesines and can break out and go to your bile duct where ur liver is.
Giardia lambia
Montezumas revenge
Ways that disease is spread
Physical contact
Contaminated food
Infected animals
Vectors
Things that carry pathogens from person to person
Antibiotics
Drugs that kill bacteria without harming cells of the host. The bacteria eats the antibiotic ( protein) and the protein gets incorporated into the skin of the bacteria. As the bacteria grows the skin stretches and it tears bc the skin is weak where the antibiotic protein is and the bacteria bursts and dies
Yersinia pestis
Carried by rats, created powerful toxins that destroy neighboring cells
Antiseptics
Kill bacteria outside of the body
Immunity
The ability to fight off pathogens
Types of immunity
Nonspecific defenses
Immune response
Specific defenses
Nonspecific defenses
Not for any particular pathogens.
Example: the acid nature of skin prevents bacteria from growing and mucus saliva and tears produce lysezyme which is a chemical tha lyses bacteria
Immune response
Specifically inflammatory response: things swell when you cut yourself bc the fluid from plasma floods into tissues to keep things packed tightly to prevent injury and bones from moving.
White blood cells squeeze outta capillary walls and move toward the place of injury and start eating foreign substance
Specific defenses
Humoral and passive immunity
Humoral immunity
(Humor-fluid filled space) for humans it’s in our bone marrow. Responsible for producing antibodies
Passive immunity
Can be natural or acquired. It’s gained naturally when babies are breast fed bc the receive antibodies from mom or when a baby is born and antibodies cross the placenta. It is acquired when rhogam (an injection of antibodies is given). Acquired passive immunity is simply when u get antibodies from an outside source
Antigen
Foreign protein that antibodies attach to
Cell mediated immunity
The t lymphocytes that know about the type of invader go to the macrophage (a lathe granuoclyte) where it gets converted to a killer T cell which is a lymphocyte programmed to go after only one antigen
Allergies
Immune response against foreign protein usually things you’ve inhaled. When protein gets into your mucus membranes your eyes water, you cough and sneeze in
Histamine
The things that cause swelling. As a group called MAST cells which have granules that release histamines that cause allergies
RAST test
Rapid antigen stimulation test
Anaphylactic shock
Antigens are in the blood stream. They might result in your airways closing and death. Epinephrine pens are given to people with severe allergies to countereact the stop the anaphylactic shock
Lupus
Only attacks women’s connective tissues makes them look like they have a goggle tan
AIDS hiv
HIV is the virus that destroys your immune system and then a disease kills you. There is no cure. HIV stands for human immno deficiency. It’s called aids when you start showing symptoms