Chapter 4- Integumentary System Flashcards
2 components of the integumentary system
- cutaneous membrane
2. accessory structures
Cutaneous membrane divided into..
epidermis
dermis
Ex. of accessory structures
- hair
- nails
- glands
Functions of Integumentary system
- protects deeper tissues from damage (mechanical, chemical, bacterial, desiccation, etc)
- aids in heat regulation
- airds in excretion of urea and uric acid
- synthesizes Vitamin D
Epidermis Characteristics
- stratified squamous epitherlium
- lacks blood vessels but can divide
- as new cells divide, push older ones to surface
- outer most layers are dead
Epidermal cell types
keratinocytes
melanocytes
langerhan cells
merkel cells
Keratinocytes
- epidermal
- 90% of cells
- produce keratin
- provide protection
melanocytes
~8% of cells
- produces melanin pigments which protect against UV radiation
- melanin transferred to other cells with long cell processes
langerhan cells
- from bone marrow
- part of immune response
merkel cells
- in deepest layer
- form touch receptor with sensory neuron
What cells are produced at the basal lamina
keratinocytes by stem cells
what happens after keratinocytes are made
they are pushed towards surface
- fill with keratin and oils
- slowly die
- 4 week journey
layers of epidermis
- stratum germinativum
- stratum spinosum
- stratum granulosum
- stratum lucidum
- stratum corneum
Stratum germinativum
- deepest single layer of cells
- combination of merkel cells, melanocytes, keratinocytes and stem cells
How do stratum germinativum attach to basal lamina
desmosomes and hemidesmosomes
stratum spinosum
- 8-10 cell layers held together by desmosomes
- melanin taken in by phagocytosis from nearby melanocytes
- during slide prep, cells shrink and look spiny
stratum granulosum
3-5 layers of flat dying cells
-show nuclear degeneration
what does stratum granulosum contain that are important for dessication?
contains dark staining keratohyalin granules
-release lipid that repels water
stratun lucidum
- seen in thick skin on soles and palms of feet only
- three to 5 layers of clear flat dead cells
stratum corneum
25-30 layers of flat dead cells filled with keratin and surrounded by lipids
- continuously shed
- barrier to heat, light, water, chemicals and bacteria
what layer do callus’s form on and what causes them?
stratum corneum
-friction
Thick skin
- palmer and planter surface
- about 30 layers of S. corneum
- all 5 layers
thin skin
rest of body surfaces
- fewer layers of S. Corneum
- no S. lucidum
epidermal ridges
- stratum germinativum forms ridges that extend into the dermis
- increases area of contact for better grip
where is melanin produced
epidermis by melanoctes
melanin
same number of melanocytes in everyone but varying amounts of pigment
- melanin production is in response to melanin stimulation hormone
- UV in sunlight increases melanin production
what gets converted to melanin
melanocytes convert tyrosine
different types of melanin
- eumelanin-brown or black melanin
- pheomelanin-red brown version
What are freckles or liver spots
melanocytes in a patch
mole
benign localized overgrowth of melanocytes (nevus)
albinism
inherited lack of tyrosinase; no pigment