Chapter 3 Part 2

Question 1

Tissue repair

Answer 1

Regeneration and fibrosis

Question 2

Regeneration

Answer 2

Replacement of dead cells

Question 3

Fibrosis

Answer 3

Scar tissue develops

Question 4

Shrinkage and death

Answer 4

Atrophy, necrosis, apoptosis, and denucleation

Question 5

Atrophy

Answer 5

Reduce in size/number

Question 6

Necrosis

Answer 6

Tissue death (patshological) infarction and gangrene

Question 7

Infarction

Answer 7

Cut off blood supply

Question 8

Apoptosis

Answer 8

No effect to neighbor cells

Question 9

Denucleation

Answer 9

Nucleus removed/ destroyed and there is no effect on cells neighboring. Ex: red blood cell spits out nucleus when it leaves the marrow. Epidermis also has 30-40 day cycle also crystalline lens that live w it hout nucleus till you die

Question 10

Nucleated terminal differentiation

Answer 10

Does not regenerate if it dies it n will not come back like a neuron

Question 11

Eyecells/crystallinelens

Answer 11

Have long mRNA and lives forever because translation keeps the cell going l (light bulb and generator) lens get bigger as you age

Question 12

Terminal differentiation.

Answer 12

Cell can no longer change) be changed into another cell type. B-cells rearrange immunoglobulin genes so they can only form single type of immunoglobulin

Question 13

Viral infections

Answer 13

Papillomavirus interferes with cell p53 protein which interferes with apoptosis and leads to cervicle cancer

Question 14

P53 protein

Answer 14

Regulates gene expression, its a tumor protein One type is nucleostemin protein

Question 15

G1

Answer 15

DNA damage checkpoints if p53 protein is detected cell is not allowed to enter S phase and apoptosis happens

Question 16

Cells with denucleation

Answer 16

Corneocytes, Rbc, ocular secondary lens fib (RBC last 120 days)

Question 17

Non denucleation

Answer 17

-neuron (if it is damaged it never regenerates (cant go through mitosis again ))
-melanocyte (5 to 10 % of cells in the basal layer, number and quantity lead to different skin colors, albinose have no tyrosinase which produces melanin from tyrosine amino acid) also protection from UV rays
-adipocyte