Chapter 23: Microbial Diseases of the Cardiovascular System Flashcards
Septicemia
- persistant pathogens or their toxins enter the blood
Sepsis
SIRIS
Septic shock
final stage
what is an example of septicemia
lymphangitis
what is an example of spesis
pueperal sepsis
pueperal sepsis is caused by
s. pyogenes (GAS)
pueperal sepsis
- caused by s. pyogenes (GAS)
- abdominal cavity infection
- treatment: penicillin
- often not caught
what is the treatment for pueperal sepsis
penicillin
- often not caught
Rhematic fever
- “sequal to”
- GAS
- symptoms: fever, arthritis (nodules form), inflammation of the mitral valve 9valve replacement), chest pain, murmurs, death
what bacteria is rhematic fever caused by
s pyogenes
how does s pyogenes attach
m proteins
gangreen produces what toxin
Alpha toxin
alpha toxin
- produced by Gangreen
- breaks plasma membrane of blood vessels
- inhibits formation of lecithin
gangreen causes
gun shot wounds, diabetics, improper abortion, fracture, deep wounds
Gangreen
- produces alpha toxin
- causes necrosis
- symptoms: pain, fluid blood, blackening of skin (necrosis), gas formation (“pop and crackle noise) –> CO2, Hydrogen
what bacteria causes gangreen
Clostridium perfringes
progression of gangreen
Ischemia, necrosis, gangreen, gas gangreen
Ischemia
loos of blood suppy to the tissue
necrosis
dealth of the tissue
what toxins does anthrax produce
- protective antigen
- lethal toxin
- edema toxin
protective toxin
entery
lethal toxin
evades phagocytosis
edema toxin
swelling of entery
Anthrax treatment
vaccine (not common)
- 6 doses + yearly
anthrax was discovered by
robert koch
what bacteria casues anthrax
bacillus anthracis
- endospore
- bioweapon
- spread through soil
what are the three manifestations of Anthrax
- GI
- Pulmonary
- skin/ cutaneous
Gi manifestation of anthrax
- hemmoraging
- 50% morality rate
- caused by undercooked, contaminated meat
Pulmonary manifestation of anthrax
- septicemia
- 1005 mortality rate
- inhalation of endospores
Skin / Cutaneous manifestation of anthrax
- eschar
- 20% mortality rate
- treatment: pencillin, cipro
how is anthrax treated
Ciprofloxacin
Spotted fever is caused by which bacteria
Rikettsia rickettsi
spotted fever caused a
macular rash
- accompanied by fever and headache
What micorbail doseases of the cardiovascular system are caused by protozoa
Malaria
what are the hosts of malaria
mosqutios, humans
life cycle of malaria in mosquitos
Sporozoite –> blood –> liver –> Meroites –> rupture –> blood RBC’s (ring stage)–> burst –> more merozoids produced –> male and female gametes –> zygote –> Sporozoite
life cycle of malaria in humans
Sporozoite –> blood –> liver –> Meroites –> rupture –> blood RBC’s (ring stage)–> burst –> more merozoids produced –> released –> blood:RBC’s
HHSV -4 / EBV
abnormalities in B cells
- growth + latency
HHSV-4 / EBV causes (4)
- Birkitt’s lymphoma
- nasopharynx cancer
- mono
- chronic fatigue syndrome
Birkitt;s lymphoma
- fast growing tumor of the jaw
Mono
-“kissing disease” (transmitted via saliva
- long incubation period (4-8weeks)
- affects 1.5 million collage students per year
- symptoms: fever, sore throat, fatigue, swollen lymph nodes, enlarged spleen
chronic fatigue syndrome symptoms
- decrease muscle
- decrease memory
- increase titer of EBV
HHSV-5 / Cytomegalovirus (CMV)
- inflammation of T cells
- have inclusions (owl eyes)
- transmitted: saliva, semen, vaginal fluid, placenta
- causes retinitis (blindness)
