chapter 15; physical and cognitive development in late adulthood Flashcards
The term for the maximum number of years an individual can live is considered as
the life span
in life span what are the maximum number of years an indiividual can live
120 to 125 years
are more or less individuals living past the age 65
more
since the 1900s what has allowed for life expectancy to increase by an average of 31 years
improvements in
medicine
nutrition
exercise
life style
before the twentieth century did many individuals live past or die before or after reaching the age of 65
die before
the concept of a period called “late adulthood” begins in the
60s or 70s
what is the term for the number of years that the average person born in a particular year will probably live
life expectancy
what is the average that 65 year olds in the United States today can expect to live an average of more years
19.5
females - 20.6
males - 18.4
what is the average years that people who are 100 years of age expect to live more
2.3 years longer
in 2015, what is the country that had the highest estimated life expectancy at birth of 90 years
monaco
followed by
Japan
singapore
macau
in 2015, which countries had the lowest estimated life expectancy
(50) Chad and Guinea Bissau (African countries)
(51) Swaziland and Afghanistan
the differences in life expectancies across countries are due to factors such as
health conditions and medical care
ethnic differences
why is the life expectancy in the US expected to be the lowest
has highest;
- child and maternal mortality rates
- homicide rate
- Body mass index of high income countries in the world
why is the life expectancy for South Korea expected to have the largest growth
- delayed onset of chronic diseases is occurring
- children’s nutrition is improving
- low rate of obesity
- high blood pressure isn’t as high
in 2017, what was the overall life expectancy for women and for men
women - 81 years of age
men - 77 years of age
is there a gender gap in longevity between men and women
yes decreased from 7.8 to 4 years
when does the gender gap in longevity begin between women and men
beginning in the mid thirties (when women outnumber men)
gap widens during the remainder of the adult years
in lists of the oldest people alive in the world today are there men and women in the top 25
no men
what are social factors that say that women can expect to live longer than men
health attitudes
habits
lifestyles
occupation
are probably important
what are the leading causes of death that men rather than women are likely to die of
cancer of the respiratory system
motor vehicle accidents
cirrhosis of the liver
emphysema
coronary heart disease
(associated with lifestyle)
are women or men more likely to die from some diseases such as Alziehmers disease and some aspects of cardiovascular disease, such as hypertension related problems
women
since men are more heavier smokers than women are what does the difference in sex cause higher chances of death due to the smoking
lung cancer and emphysema
can sex differences in longevity also be influenced by biological factors
yes
why can females outlive males in virtually all aspects
- more resistance to infections and degenerative disease
- estrogen production helps to protect her from arteriosclerosis (hardening of the arteries)
does the addition X chromosome that women have associate with outliving males
yes
why?
because may be associated with the production of more antibodies to fight off disease
the sex difference in mortality is still present in late adulthood but […] pronounced than earlier in adulthood, and it is especially linked to the […] level of cardiovascular disease in men and women
less
higher
despite physical limitations, what do centenarians have a low rate of and most have
low rate of age associated diseases
most had good mental health
how old are supercentenarians considered
110-119
does being 100 to 119 years of age affect the onset of disease and function
yes, it laters the onset
- cancer and cardiovascular disease
- functional decline
what are centenarians
individuals 100 years and older
is the rate of centenarians increasing or decreasing
increasing 7% each year in industrialized countries
what did Thomas Perls and his colleagues research in the New England Centenarian Study (NECS)
that it is not true that the older you get, the sicker you get
Thomas Perls’ term for the process of staving off high mortality chronic diseases until much later ages than is usually the case in the general population: he calls it the
compression of morbidity
in the list of super centenarians were men in the list of the top 25
only two
what did NECS study discover a strong component to living to be 100 that consists of many genetic links, each with modest effects but collectively having a strong link
strong genetic component
what are among the factors that are associated with living to be 100 regarding centenarians
longevity genes and the ability to cope with stress effectively
where is the highest ratio of centenarians in the world
in Okinawa
what are characteristics of centenarians in the NECS studying
- few of the centenarians are obese,
- habitual smoking is rare
- only a small percentage (less than 15) have had significant changes in their thinking skills (disproving the belief that most centenarians likely would develop Alzeihmers disease)
what were US and Japanese centenarians linked to a higher level of well being in
health resources
(better cognitive function, fewer hearing problems, positive activities in daily living)
what did 34.7 centenarians for every 100,000 inhabitants, attribute to
diet
low stress lifestyle
caring community
activity
spirituality
what are four biological theories producing explanations on why we age
evolutionary
cellular clock
free radical
hormonal stress
in the biological theories of aging what is evolutionary theory of aging
natural selection has not eliminated many harmful conditions and nonadaptive characteristics in older adults
why has natural selection not eliminated many harmful conditions and nonadaptive characteristics in older adults
because natural selection is linked to reproductive fitness, which is present only in the earlier part of adulthood
what is a critic of the evolutionary theory
- The idea that natural selection shapes human traits and behaviors is hard to challenge or test because evolution happens over such long periods that it can’t be directly studied through experiments.
- the failure to account for cultural influences
in the four biological theories of aging, evolutionary theory’s benefits conferred to evolution decline with age because
natural selection is linked to reproductive fitness
what are the five advances in research regarding genetic and cellular process involving aging
telomeres,
free radicals,
mitochondria,
sirtuins,
and the mTOR pathway
what is Leonard Hayflick’s (1977) cellular clock theory
that cells can divide a maximum of about 75 to 80 times and that as we age out cells become less capable of dividing
based on the way cells divide what did Hayflick place the upper limit of human life span potential at
about 120 to 125 years of age
what are telomeres
tips of chromosomes; DNA sequence that cap chromosomes
(scientists have tried to fill in a hap in cellular clock theory)
after how many times can the the cell replicate before the cell can no longer reproduce
70 to 80 replications
(are dramatically reduced)
did healthy centenarians have longer or shorter telomeres than unhealthy centenarians
longer
what does having a shorter telomere link to
Alzheimer’s disease
what does injecting the enzyme telomerase into human cells grown in the laboratory can substantially do
extend the life of the cells beyond the approximately 70 to 80 normal cell divisions
however, what is telomerase present in approximately 85 to 90 percent of
cancerous cells and thus may not produce healthy life extension of cells
what are researchers training to do with telomerase and lead to with cancer cells
inhibit telomerase and lead to the death of cancerous cells while keeping healthy cells alive
what are telomeres and telomerase increasingly thought to be key components of
stem cell regeneration process, proving a possible avenue to restrain cancer and delay aging
what is free radical theory; the third theory of aging
states that people age because when cells metabolize energy, the by products include unstable oxygen molecules known as free radicals
since the free radicals ricochet around the cells; what does it lead to
damaging DNA and other cellular structures
what can the damage lead to; (disorders)
cancer and arthritis
can overeating cause an increase or decrease in free radicals
increase
what can a calorie restriction do to free radicals when the diet is low in calories but adequate in proteins, vitamins, and minerals
reduces the oxidative damage created by free radicals
what can endurance exercise do to obese men regarding their oxidative damage
reduce it
what is the mitochondrial theory
aging that emphasizes the decay of mitochondria-tiny bodies that supply essential energy for function, growth and repair-that is primarily due to oxidative damage and loss of critical micronutrients supplied by the cell
what has been emphasized as key aspects of the mitochondrial theory of aging
energy sensing and apoptosis (programmed cell death)
what are the range of disorders mitochondrial damage can lead to
cardiovascular disease,
neurodegenerative disease
e.g. Alzeihmers
Parkinson disease
diabetic kidney disease
impaired liver functioning
is it known in the mitochondrial theory if the defects of mitochondria cause aging or are merely accompanying the aging process
not known
what is the Sirtuin theory
family of proteins that have been linked to longevity, regulation of mitochondria functioning in energy, possible benefits of calorie restriction, stress restistance, and a lower incidence of cardiovascular disease and cancer
which sirtuin has been connected to DNA repair and aging
SIRT 1
what is the mTOR pathway theory
cellular pathway that involves the regulation of growth and metabolism , central role in cell life including stem cells (acting as a cellular router for growth)
what does TOR stand for
target of rapamycin.
in mammals its called mTOR
what is rapamycin
naturally derived antibiotic and immune system suppressant/modulator, first discovered in the 1960s on Easter Island
since rapamycin is commonly used and is FDA approved what is it used for
preventing organ rejection and in bone marrow transplants
what do scientists argue of the mTOR pathway being linked to
- longevity,
- the successful outcomes of calorie restriction,
- and reduction in cognitive decline
- may influence the course of a number of diseases
e.g. cancer, cardiovascular disease, Alzeihmer disease
has rapamycin not been approved as an anti aging drug
No, has some serious side effects, including increased risk of infection and lymphoma, a deadly cancer
what do some critics argue of the scientific support for sirtoins and the mTOR pathway as a key cause for aging in humans, has not being found and that
research has not adequately documented the effectiveness of using drugs such as rapamycin to slow the aging process or extend the human life span
what is the hormonal stress theory when thinking of biological theories of aging
aging in body’s hormonal system can lower resistance to stress and increase likelihood of disease
since when people experience stressors, the body responds by releasing certain hormone, what happens to the hormones stimulated by stress
remain at elevated levels longer than when people were younger
what are prolonged elevated levels of stress related hormones associated with an increased risk of
many diseases;
including cardiovascular disease,
cancer,
diabetes,
and hypertension
is exercise one of the stress buffering strategies that researchers are exploring in an effort to find ways to attenuate some of the negative effects of stress on the aging process
yes
how does age relate to the decline in immune system
the percentage of T cells (a type of white blood cell essential for immunity) decreased in older adults in their seventies, eighties, and nineties
does aging contribute to immune system deficits that give rise to infectious diseases in older adults
yes
can extended duration of stress and diminished restorative process in older adults may accelerate the effects of aging on immunity
yes
what happens to the aging brain in late adulthood
shrinks and slows, but still has considerable adaptive ability
on average, how much does the brain lose in percentage of its weight
5% to 10% between ages 20 to 90
does the brain volume and volume in key brain structures decrease in late adulthood from 22 to 88 years of age
yes, such as as the frontal lobes and hippocampus
brain volume decreases due to
- shrinkage of neurons
- lower numbers of synapses
- reduced length and complexity of axons
- reduced tree like branching in dendrites
does neuron loss occur for individuals with Alzeihmers
yes
can global brain volume predict mortality in large populations of stroke free community dwelling adults
yes
do all brain areas shrink equally with aging
no, some shrink more than others
Is the prefrontal cortex an area that shrinks with aging
yes, decrease in working memory and other cognitive activities in older adults
what are the sensory regions of the brain that are less vulnerable to the aging process
yes such as the
primary visual cortex,
primary motor cortex,
and somatosensory cortex
When does the general slowing of function in the brain and spinal cord accelerate with aging
Begins in midlife and accelerates in late adulthood
what does it affect?
physical coordination and intellectual performance
In the concept of the aging brain, what is aging linked to
- reduction in synaptic functioning
- and the production of neurotransmitters
after age 70 what do many adults no longer show, what happens by age 90
a knee jerk reflex, and by age 90 most reflexes are much slower
what does slowing of the brain do to performance to older adults with intelligence and especially timed tests
impair performance
since aging reduces the production of neurotransmitters, what does the reduction of acetylcholine link to
memory loss, especially in people with Alzheimer’s disease
in the concept of the aging brain what are severe reductions in dopamine involved in the reduction in
motor control in Parkinson disease
is demyelination (deterioration in the myelin sheath that encases axons and is associated with information processing) occur in the brains of older adults
yes
since the human brain has remarkable repair capability, can activities older adults engage in still influence the brains development
yes, since the brain loses only a portion of its ability to function, the activities can still influence the brains development
in the concept of the adaptive brain, in an fMRI study, what do higher levels of aerobic fitness link to
greater volume in the hippocampus, which translate into better memory
what is neurogenesis
generation of new neurons
in only the hippocampus (memory)
olfactory bulb (smell)
what are the functions of the neurogenisis neurons and how long go they last
not know what function they perform, last only for several weeks
can dendritic growth occur in human adults, possibly even in older adults
yes;
are the receiving portion of the neuron
from what age did the growth of the dendrites increase, and from what age did growth no longer increase
growth - 40s to the 70s
no growth - 90s
older brains rewire to compensate for […]
losses
decrease in lateralization is using both hemispheres to …
process information.
(improves cognitive functioning)
lateralization is the specialization of function in one hemisphere of the brain or the other
yes
In older adults are using neuroimaging techniques, researchers have found that brain activity in the prefrontal cortex is lateralized […] when they are engaging in cognitive tasks
less
e.g.
when younger adults are given the task of recognizing words they have previously seen the process the information primarily in the right hemisphere, older adults are more likely to use both hemispheres
does using both hemispheres improve the cognitive functioning of older adults in their aging brain
yes
in the Nun study directed by David Snowdon studied
ow their intellectually challenging life, contributes to their quality of life as older adults and possibly their longevity
are the timing of physical problems related to aging uniform
no
what physical appearance changes that began in midlife become more pronounced that are the most noticeable
wrinkles and age spots
in late adulthood do we get shorter as we get older
yes,
because of bone loss in their vertebrae
what happens to weight after age 60
drops (gives sagging look);
muscle loss
exercising is beneficial for overall heath and fall risk reduction
since muscle loss occurs in late adulthood, what was linked with greater muscle strength in 65 to 86 year olds
long term aerobic exercise
do older adults move more slowly or faster than young adults
slowly
is having adequate mobility have an important aspect of maintaining an active lifestyle in late adulthood
yes
by maintaining an independent and active lifestyle
does obesity link to mobility limitation in older adults
yes
can at risk overweight and obese older adults can lose significant weight and improve their mobility considerably by participating in a community based weight reduction program
yes
can exercise benefit frail elderly adults
yes
through?
high intensity walking
(increase walking speed + balance)
a 10 week exercise program improved the physical (aerobic endurance, agility, and mobility) and cognitive function (selective attention and planning) of elderly nursing home residents
yes
what happens to the risk of falling in older adults, does it increase or decrease with age. does it increase more for women or men.
increases with age
greater for women than for men
falls are the leading cause of injury deaths among adults who are […] years and older
65
side note;
approx. 200k adults over 65 (many women) fracture a hop in a fall
half of the older adults who take a fall and may fracture a hip…
die within 12 months, frequently from pneumonia.
exercise […] falls in adults 60 years of age and older
reduces
in summary, from 65 to 74 regarding the loss of vision; there is a […] of acuity even with corrective lenses. […] transmission of light occurs through the retina (half as much as in young adults). […] susceptibility to glare occurs. Color discrimination ability […]
loss
less
greater
decreases
in summary, from 75 y/o and older what happens regarding the loss of vision; there is a significant […] of visual acuity and color discrimination, and a […] in the size of the perceived visual field. in late old age, people are at significant risk for visual dysfunction from cataracts and glaucoma.
loss
decrease
in summary, from ages 64 to 74 years old in hearing loss, there is significant [..] of hearing at high frequencies and some […] at middle frequencies. these losses can be helped by a hearing aid. there is […] susceptibility to masking of what is heard by noise
loss
loss
greater
in summary, hearing loss in 75 years and older. there is a significant […] at high and middle frequencies. a hearing aid is more likely to be needed than in young old age
loss
what are the most prevalent chronic conditions in late adulthood
- arthritis
- hypertension
- hearing impairments
- heart conditions
- chronic sinus problems
- visual impairments
- orthopedic impairments of the back, extremities, etc.
- arteriosclerosis
- diabetes
visual decline in late adulthood 65+ is linked to
- cognitive decline
- having fewer social contacts and engaging in less challenging social/leisure activities
when is the decline in vision becoming more pronounced for most adults
began in early or midlife
when vision starts to decline can it adapt as quickly when moving from a well lighted place to one of semidarkness. can it also tolerate glare
no
since vision declines, the visual field becomes […], and events that occur away from the center of the visual field are sometime not […]. all f these changes can make night driving especially […]
smaller
detected
difficult
since depth perception also decline in late adulthood what does depth perception make difficult
make it difficult for older adults to determine how close or far away or how high or low something is
what does a decline in depth perception make difficult to navigate
steps or street curbs
what are the three vision diseases that can impair the vision of older adults
cataracts, glaucoma, and macular degeneration
what is the cataract disease
the thickening of the eye’s lens causes vision to become cloudy, opaque, and distorted
30% by age 70
how can cataracts be treated
by glasses
or if worsen through a simple surgical procedure that replaces the natural lenses with artificial ones
what is the glaucoma eye disease
damage to the optic nerve because of pressure created by fluid buildup in the eye
what was the difference between older adults who had cataract surgery than those who did not have the surgery, with the mean age being 76 years old
less likely to develop mild cognitive impairment than their counterparts
how can glaucoma be treated
eye drops
if left untreated, can ultimately destroy a person’s vision
what does the eye disease Macular degeneration
deterioration of the retina’s macula, which corresponds to focal center of the visual field
what do individuals with macular degeneration have
relatively normal peripheral vision but be unable to see clearly what is in front of them
(increased using stem cell based therapy to treat it)
what is hearing loss
inability to hear sounds softer than 25 dB with their better ear