Chap. 16 (Vocab) Flashcards
Transformation
Change in genotype and phenotype due
to assimilation of foreign DNA
Pathogenic
Disease-causing
Nonpathogenic
Harmless
Bacteriophages/ Phages
Virus that infects bacteria
Virus
Infectious microbe consisting of a segment of nucleic acid (either DNA or RNA) surrounded by a protein coat
Double Helix
Two strands of nucleotides twist around each other, with sugar-phosphate backbone + nitrogenous bases held together by hydrogen bonds
Antiparallel
Arrangement of sugar-phosphate backbones in double helix (5’s and 3’)
- Subunits run in different directions
DNA Replication
DNA is copied and synthesized
Semiconservative Model
Replicated double helix consists of one old strand derived from parental molecule and one new strand.
Origin of Replication
Site where replication of DNA molecules begins
Replication Fork
Y-shaped structure where a DNA double helix splits into two strands for copying
Helicases
Enzyme that actively separates the two strands of a double-stranded nucleic acid molecule (like DNA or RNA) into single strands
Single-strand Binding Proteins
protein that binds to unpaired DNA strands during replication, stabilizing and holding them apart
Topoisomerase
Enzyme that controls the structure of DNA by breaking and rejoining DNA strands
Primer
Short nucleic acid sequence that provides a starting point for DNA synthesis
Primase
Enzyme that creates RNA primers to initiate DNA replication
DNA Polymerase
Enzyme that is responsible for forming new copies of DNA, in the form of nucleic acid molecules
Lagging Strand
One of two strands of DNA that are created during DNA replication
Okazaki Fragments
Short DNA sequences that are created during DNA replication when the lagging strand is made of short fragments
DNA Ligase
Enzyme that joins DNA strands together by forming phosphodiester bonds
Mismatch Pair
Enzymes that remove + repair incorrect nucleotides
Nuclease
Enzymes that are specially designed to break apart the nucleotides
Nucleotide Excision Repair
DNA repair mechanism that removes damage from DNA strands caused by radiation, chemicals, and other mutagens
Chromatin
Complex of DNA and protein inside nucleus of eukaryotic cells
Nucleosome
Units of DNA + proteins that condenses DNA into compact form for storage in nucleus
Histones
Proteins that help chromosomes form and regulate gene activity
Euchromatin
Lightly packed form of chromatin (DNA, RNA, and protein) that is enriched in genes
Heterochromatin
Densely packed, highly condensed form of chromatin (DNA and associated proteins) within a chromosome, typically containing repetitive DNA sequences and considered largely inactive for gene transcription
Telomeres
Repetitive DNA sequence at end of chromosome