Ch 49 disorders of thyroid Flashcards
how are T3 and T4 made
- hypothalamus makes TRH
- anterior pituitary makes TSH
- thyroid makes T3 and T4
term for normal thyroid
euthyroid
visible symptom of enlarged thyroid gland
goiter
treatment thyroiditis (3)
- drug therapy
- surgery
- lifelong hormone replacement
chronic autoimmune condition caused by destruction of thyroid tissue by antibodies, goiter present
hashimotos thyroiditis
what is the thyroid responsible for in the body
regulating cellular metabolism
most common form of hyperthyroidism
graves disease
syndrome: physiological effects of hypermetabolism resulting from excess thyroid
thyrotoxicosis
S+S hyperthyroidism (graves disease) (6)
- increased HR
- decreased weight
- diarrhea
- fine straight hair
- exophthalmos
- heat intolerance
S+S acute thyrotoxicosis (6)
- tachycardia
- heart failure
- hyperthermia
- seizures
- V/D
- coma
how to distinguish graves disease from other forms thyroiditis/hyperthyroidism
RAIU test
graves has higher uptake of blood by thyroid (35-95%) and thyroiditis has uptake of less than 2%
how are TSH and T4 levels affected by hypothyroidism
increased TSH
decreased T4
how are TSH and T4 levels affected by hyperthryoidism
decreased TSH
increased T4
antithyroid med that blocks conversion of T3 to T4; preferred during pregnancy
propylthiouracil (PTU)
antithyroid med that blocks production of T3 and T4; contraindicated during pregnancy; high doses needed for thyroid storm
methimazole