Ch 16 (test 3)

Question 1

Parkinson’s disease

Answer 1

progressive chronic neurological disorder without a cure.

Question 2

Antiparkinson’s drugs

Answer 2

given to mange the signs and symptoms of Parkinson’s to provide quality of life… NOT CURE.

Question 3

Parkinson’s cause

Answer 3

imbalance of dopamine (too much) and acetylcholine (too little).

Question 4

Signs of parkinsons

Answer 4

1. Coordination difficulty
2. pill rolling tremors
3. bradykinesia
4. shuffling gait.
5. drooling and slow/slurred speech
6. flat affect (mask).

Question 5

MAOI’s MAO inhibitors (monoamine oxidase inhibitors)

Answer 5

given to prevent the breakdown of dopamine.

Question 6

Eldepryl

Answer 6

1. MAOI

2. given with levodopa so less can be given.

Question 7

Type 1 antiparkinson drugs

Answer 7

Dopaminergics: increase dopamine levels

Question 8

Levodopa

Answer 8

1. crosses blood-brain barrier and is converted to dopamine

2. side effects: fatigue and lethargy, postural hypotenstion, increased sweating, dark urine.

Question 9

Sinemet

Answer 9

antiparkinsons drug

mixture of levidopa and corbidopa.

Question 10

antiparkinsons drug teaching

Answer 10

1. avoid heat
2. no B6 with levodopa
3. Round the clock
4. drug holiday for 10 days
5. can take 3-4 weeks to see effects.
6. no alcohol
7. debilitating between 5-10 years after start of therapy.

Question 11

Requip

Answer 11

newer drug for PD treatment and RLS

Question 12

Catechol-ortho methytransferase COMT inhibitors

Answer 12

prolong the duration of levodopa so there is less off time

Tasmar and Comtan`

Question 13

Type 2 antiparkinson’s drugs

Answer 13

Anti-cholinergics: oppose acetylcholine at receptor sites in the brain to help restore

Question 14

Cogentin

Answer 14

1. type 2 antiparkinsons drug
2. decrease the rigidity of parkinsons and decreases the muscle tremors that occur with excess cholinergic activity.
3. SE: confusion, dry mouth, constipation, urinary retention, decreased ability to sweat.