Cell Mediated (II) Flashcards
What are MHC made of
Glycoproteins with domains
Which cells do MHC I activate
CD8 for intracellular / endogenous peptides
Which peptides do MHC II hold
Exogenous (endocytosed then cleaved by proteases)
Which 3 alleles of HLA genes encode for MHC I (3 a , 1 B2)
HLA - A,B,C
Which alleles encode for MHC II (2a,2b)
HLA - dp,dq,dr
Which chromosome holds HLA genes
16
Which cells is MHC 1 on
All nucleated cells (any virally infected can express them)
What makes MHC so polymorphic
Many alleles for the A chain
HLA A,B,C all have different a chains which make up the MHC 1
What is difference between MHC 1 peptide vs MHC 2
Shorter (8-10 AA long)
Which part of MHC 1 isn’t polymorphic
B2 micro globulin
How do A1,a2 on MHC 1 bind to 8-10 AA peptide
H bonds or ionic bonds
Which structure makes up the A1,A2 domains on MHC 1
2x beta sheets
2 x alpha helixes
(Highly polymorphic)
How is a3,B2 different to A1,a2
Ig like - only beta chains
Low polymorphisms
How long is polypeptide that A1,B1 bind to in MHC II
13-24 AA long (longer)
Where is the highest polymorphisms in MHC II of the dp,dq and dr alleles
A1, B1 (peptide cleft)
A2, B2 is ig like