Cell Division Flashcards
how many chromosomes in humans?
46 chromosomes (23 homologous pairs)
what does a centrosome contain?
pair of centrioles
centrioles
produce spindle fibers that separate sister chromatids during anaphase
regulation of cell cycle
- surface-volume ratio
- genome-volume ratio
surface-volume ratio
if the volume ratio is small when cell is too big it makes cell exchange hard leading to cell death/division to increases surface area
genome-volume ratio
if it decreases, the cell exceeds ability of its genome to produce proteins needed to regulate the cell
cell cycle
interphases consiting of G1, S, G2 phase
when does interphase occur?
after mitosis and cytokinesis
G1
cell increases in size and G1 checkpoint ensures everything is ready for DNA synthesis
where does most cell growth occur?
G1 phase
S phase
DNA synthesis; 2nd molecule of DNA replicated from 1st into sister chromatids
where is DNA replicated?
S phase
G2 phase
rapid cell growth; preparation of genetic material for cell division, cell replicates organelles
G0 phase
inactive state of cells not actively growing/dividing
- nerve and & cardiac cells
when does the spindle apparatus form?
during prophase
what does each sister chromatid have?
kinetochore
where does kinetochore attach
MT attach’ MT don’t directly attach to chromosomes
prophase chromosomes/chromatids
46 chromosomes
92 chormatids
metaphase chromosomes/chromatids
46 chromosomes
92 chromatids
anaphase chromosomes/chromatids
92 chromosomes
92 chromatids
telophase chromosomes/chromatids
92 chromosomes
92 chromatids
cytokinesis chromosomes/chromatids
46 chromosomes
46 chromatids
prophase
- nuclelus disassembles, nucleoulus disappears
- chromatin condenses into chromosomes
metaphase
- chromosomes line up
- each metaphase chromosome consists of 2 attached chromosomes
- each chromatid complete with centromere and attached kinetochore
anaphase
- MT shorten and each chromosome is pulled apart into 2 chromatids
- chromatids pulled to opposite poles disjunction
- at the end each pole has a complete set of chromosomes
telophase
- nuclear envelope reforms
- chromosomes decondense back into chromatin and nucleoli reappear
meiosis
produces 4, non-identical haploid daughter cells from one diploid parent cell
* does this by repeating nuclear division twice
meiosis 1
homologous chromosomes separate
prophase 1 chromosomes/chromatids
46 chromosomes
92 chromatids
prophase 1
- spindle forms, nuclear envelope breaks down
- chromosomes pair up lengthwise through synapsis forming tetrads to allow for crossing over
- pairs linked with chiasmata
- MT attache to chromosomes at kinetochore and move them towards metaphase plate
chiasmata
regions where crossing over occurs
metaphase 1 chromosomes/chromatids
46 chromosomes
92 chromatids
metaphase 1
- homologous chromosomes arranged at metaphase plate
- independent assortment of chromosomes occur because arrangement is random
anaphase 1 chromosomes/chromatids
46 chromosomes
92 chromatids
anaphase 1
homologous chromosomes separate and spindle apparatus guides to opposite poles
telophase and cytokinesis chromosomes/chromatids
46 chromosomes
92 chromatids
telophase 1
- homologous chromosomes are separates from each other to each end of cell
cytokinesis 1
2 haploid daughter cells containing one chromosome for every homologous pair
meiosis II
sister chromatids separate
prophase ll chromosomes/chromatids
23 chromosomes
46 chromatids
prophase ll
spindle apparatus forms and MT move chromosomes towards metaphase plate
metaphase ll chromosomes/chromatids
23 chromosomes
46 chromatids
metaphase ll
- sister chromatids no longer genetically identical due to crossing over
- chromosomes lined up at metaphase plate
anaphase ll chromosomes/chromatids
46 chromosomes
46 chromatids
anaphase ll
- chromatids separate, move toward opposite poles
- separated chromatids now chromosomes
telophase ll and cytokinesis chromosomes/chromatids
46 chromosomes
46 chromatids
telophase ll
- nuclei formation and decondensing of chromosomes
- result is 4 genetically distinct daughter cells
sources of genetic variation
- crossing over
- independent assortment
- random joining of gametes
crossing over
non sister chromatids of 2 homologous chromosomes exchange genetifc material during prophase l
independent assortment
during metaphase l, random orientation of chromosomes allows for production of gametes with diff. assortment of alleles
genetic linkage
gene closer on chromosome more likely to be inherited together