Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Exam 2 (PARP) > Cell Adhesion > Flashcards

Cell Adhesion Flashcards

1
Q

What is the result of interaction of caherins from adjacent cells?

A

Electron dense line in intercellular space

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the two types of adherin junctions?

A

Cell-to-cell junctions

Cell-to-ECM adhesive junctions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the roles of focal adhesion?

A

Provides linkage of cell to extracellular matrix

Important for intracellular signaling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the transmembrane adhesive proteins of focal adhesion?

A

Integrin heterodimers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is a gap junction?

A

They directly connect the cytoplasm of two cells, which allows various molecules, ions and electrical impulses to directly pass through a regulated gate between cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the intergral membrane protein in gap junctions?

A

Connexin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Role of desmosomes

A

Provides firm adhesion among cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is focal adhesion?

A

The dynamic assembly of many different proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Junctional combinations

A

Junctional complex: cuboidal or columnar epithelium

Intercalated disc: Cardiac muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

3 main roles of adherens junction

A

Contribution to adhesive force between one call and another

Support to apical domain of epithelial cells

Intracellular signaling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Adhesive junctions are commonly involved in __________ for ________, ________, and ____________.

Loss of contact to adjacent cells or extracellular matrix may trigger ___________ or result in loss of ____________

A

Intracellular signaling; nuclear transciption; tumor suppression; differentiation

apoptosis; polarity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

6 connexins form __________, which is a ______________

A

Connexon; connexin hemichannel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the cytoplasmic adapter proteins in adheren junction?

A

Alpha and beta catenin

p120 catenin, afadin, vinculin, and alpha actinin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Adherin junctions

Adhesive junction with _______________ intercellular space and ____________ plaque on cytoplasmic face.

Associated with belt-like bands of _________

Encircles ____________

Found basil to ___________ in epithelial cells

A

Electrion-lucent

“Fuzzy”

Actin

Entire cell

Tight junction zonula

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Layers of basal lamina

A

Lamina lucida

Lamina densa

Lamina fibroreticularis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are some cytoplasmic proteins?

A

Kinases, transciption factots, cell polarity- related proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Types of Junctions

A

Gap Junction

Tight Junction

Adherin junctions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are transmembrane adhesive proteins that are found in desmosomes?

A

Cadherins; desmoglein; democollin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Arrangement of Intercellular Junctions. Definition of Each Arrangement

A

Macula: patch-like junction of limited extent

Zonula: junction who encircles the entire cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are tight junctions?

A

multiprotein junctional complex whose general function is to prevent leakage of transported solutes and water and seals the paracellular pathway.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Basal lamina/ basement membrane

Sheet-like arrangement of ___________proteins.

Binds __________to underlying __________

A

extracellular matrix

epithelium connective tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Which junction is a plaque like junction?

A

Gap

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

In gap junctions, the cell membranes of neighboring cells are very close together; intercellular space only ________nm. They can be found ___________. Common in ____________,_______ and ________, ______________, and ___________.

A

2-3; all basic cell types; epthelial cells, smooth and cardiac muscle cells; neuronal cells, and osteocytes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are the cytoskeletal elements of desmosomes?

A

Intermediate filaments (type depends on tissue type)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

In which junction are cells held together or attached to the extracellular matrix?

A

Adherin junctions

26
Q

What are the cytoskeletal elements of hemidesmosome?

A

Intermediate filaments

27
Q

What are the cytoplasmic adapter proteins of focal adhesion?

A

Alpha-actinin, vinculin, talin

28
Q

Heterodimers with alpha and beta subunits

A

Integrin

29
Q

Actin filaments are associated with which type of junction?

A

Tight Junction

30
Q

What is the intercellular space beween attached cells at adhesive junctions?

A

20 nm

31
Q

Tight junctions are also known as ___________

A

Occluding

32
Q

Integrins bind to extracellular matrix proteins __________,___________, and ___________.

A

Fibronectin, laminin, collagen

33
Q

Which junction has anastomosing strands of adhesive transmembrane proteins?

A

Tight junctions

34
Q

What is the cytoskeletal element in adherens junctions?

A

Actin

35
Q

In gap junctions, an aqueous channel is formed between the _________ of adjacent cells, which allows for the passage of ______________ and _____________. Connected cells are _____________ coupled for ______________ responses to _____________. Different members of the connexin family result in difference in _____________

A

Cytoplasm; small signaling molecules; ions; electronically; coordinated; stimuli; permeability

36
Q

Gap junctions are also known as____________

A

Communicating Junctions

37
Q

Integrins bind to basal lamina glycoprotein __________

A

Laminin

38
Q

What is an example of a junction found in cardiac mucscle and which types of cell adhesion comprise it?

A

Intercalated disc

Fascia adherins, demosome, and gap junctions

39
Q

What disease is linked to mutations of genes for desmosomal, hemidesmosomal, and intermediate filament proteins

A

Epidermolysis bullosa

40
Q

Connexons of one cell connect to the connexons in adjacent cell to form _____________ channel

A

Hydrophilic

41
Q

Typical components of Intercellular Junctions

A

Transmembrane adhesive protein

Cytoplasmic adapter protein

Cytoskeletal filament

42
Q

What do tight junctions control/ prevent?

A

The movement of ions and small molecules in intercellular space

43
Q

In adherens junctions, _____________ interact with cytoplasmic domains of transmembrane proteins, cytoskeletal proteins, and other cytoplasmic proteins.

A

Catenins

44
Q

Tight junctions have ____________ series of contacts to proteins of adjacent cell. The __________ is obliterated at contact site. The junctions encircles the _____________. Tight junctions are found close to the __________ end of __________ or _________ ________ cells.

A

Linear; intercellular space; entire cell; apical; cuboidal; columnar epithelial cells

45
Q

What cytoplasmic adapter proteins are found in desmosomes?

A

Desmoplakin, plakoglobin; plakophilin

46
Q

What are the components of the basal lamina/ basement membrane?

A

Heparan sulfate (glycosaminoglycan)

Collagen type IV

Fibronectin

Laminin

Entactin

Collagen type III

Collagen type VII

47
Q

What are the roles of the basal lamina or basement membrane?

A

Provides metabolic support

Filters material (barrier function)

Controls epithelial growth and differentation; prevents downward epithelial growth

48
Q

Disk-shaped adhesive junction

A

Desmosome

49
Q

What are the three components of a junctional complex?

A
  1. A band of tight junctions, forming an occluding zone in the top position
  2. A band of anchoring junctions in the middle position (zonula adherens)
  3. A circle of spot desmosomes, in the bottom position
50
Q

What is the transmembrane adhesive protein for adherens junction?

A

E-cadherin; Nectin

51
Q

What are the transmembrane proteins of tight junctions?

A

Member of claudin family (4 pass membrane proteins) and occludin (junctional adhesive molecule)

52
Q

What is pemphigus vulgaris?

A

Autoimmune disease affecting oral mucose due to production of antibodies to cadherins in desmosomes.

53
Q

What is the intercellular space between desmosomes and what are the spaces filled with?

A

30nm; higly-ordered proteins

54
Q

Where are desmosomes found?

A

Found basal to zonula adeherens in epithelial cells in band encicling cell

Scattered over lateral cell surface

55
Q

What are adherin junctions and what is a specific type?

A

protein complexes that occur at cell–cell junctions in epithelial and endothelial tissues, usually more basal than tight junctions.

Desmosomes

56
Q

What is the transmembrane adhesive proteins of hemidesmosomes?

A

Integrin

57
Q

In tight junction, transmembrane adhesive proteins interact _________ with proteins in adjacent cells.

A

Homotypically

58
Q

What are the differences between the two types of adherin junctions?

A

In cell-to-cell adhesive junctions, transmembrane adhesive proteins members of of cadherin family and cytoplasmic adapter proteins are members of the catenin family

In cell-to- ECM adhesive junctions, transmembrane proteins are members of integrin family

59
Q

Calcium ion-dependent proteins

A

Cadherin

60
Q

In hemisdemosomes, the cytoplasmic adapter proteins are_______

A

Bulbous pemphigold antigen 230 (BP230); Plectin

61
Q

What diseases are linked to connexin mutations?

A

Deafness, cataracts, Charcot-Marie-Tooth demyelinating disease, oculodentaldigital dysplasia

62
Q

What is the major role of hemidesmosomes?

A

Provides tight anchoring of epithelial cell to basal lamina and underlying connective tissue

Exam 2 (PARP) (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions