CELL 2 Flashcards
what is simple diffusion
molecules move down conc gradient
what is not required for simple diffusion (2)
- transport proteins
- input of en from
a. ATP
b. conc / electrochemical gradient
what kind of transport is channel mediated
passive
what happens in channel mediated transport (2)
- channel opens
2. ion moves through channel
what kind of transport is carrier mediated transport
passive
what happens in carrier mediated transport (3)
- ligand binds to binding site of carrier on one side of mem
- carrier re-orient so binding site faces other side of mem
- ligand released
what is active transport
molecules move up conc gradient
what does active transport require
- trasport proteins
- input of en from
a. ATP
b. conc / electrochemical gradient
PRINCIPLES OF DIFFUSION what is simple diffusion
passive movement of molecules through intermolecular spaces in mem
PRINCIPLES OF DIFFUSION what is simple diffusion not
passive transport of molecules through intermolecular spaces in mem
PRINCIPLES OF DIFFUSION what is energy that causes diffusion
energy of normal kinetic motion of matter
PRINCIPLES OF DIFFUSION what 2 properties of molecule determines if it can cross mem by simple diffusion
- solubility in lipid
2. size
PRINCIPLES OF DIFFUSION what diffuses more readily
- non polar molecules
2. smaller molecules
PRINCIPLES OF DIFFUSION what diffuses less readily
- polar molecules
2. larger molecules
PRINCIPLES OF DIFFUSION what is PM permeable to
- non polar + uncharged
2. polar + uncharged + small
PRINCIPLES OF DIFFUSION what is PM slightly permeable to
water
PRINCIPLES OF DIFFUSION what is the PM impermeable to
- polar + uncharged + large
- ions
- polar + charged
PRINCIPLES OF DIFFUSION why is there no limit to simple diffusion
does not involved fixed number of binding sites
PRINCIPLES OF DIFFUSION what kind of process is simple diffusion
non-saturable
PRINCIPLES OF DIFFUSION what is magnitude of concentration gradient
diff in conc of substance across 2 solutions
PRINCIPLES OF DIFFUSION what 4 factors influence rate of simple diffusion
- magnitude of driving force / magnitude of conc gradient
- membrane SA
- membrane permeability
PRINCIPLES OF DIFFUSION what is SA directly proportional to
rate of simple diffusion
PRINCIPLES OF DIFFUSION what is concentration gradient directly proportional to
rate of simple diffusion
PRINCIPLES OF DIFFUSION what does higher permeability translate to
higher rate of simple diffusion
PRINCIPLES OF DIFFUSION what 5 properties does mem permeability depend on
- lipid solubulity of molecule
- size of moleucle
- shape of moelcule
- temp
- diffusing distance / thickness of mem
PRINCIPLES OF DIFFUSION what causes higher permeability
- more lipid soluble
- small
- regular shaped
- high temp
- thin
PRINCIPLES OF DIFFUSION what causes lower permeability
- less lipid soluble
- large
- irregular shaped
- low temp
- thick