Carbohydrates 2: the return Flashcards

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1
Q

Name the 3 important hexoses

A

Glucose
Galactose
Fructose

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2
Q

Name the 3 important disaccharides

A

Maltose - Glu&Glu
Sucrose - Glu&Fru
Lactose - Glu&Gal

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3
Q

What feature makes some sugars be called ‘reducing sugars’

A

Anomeric C1 can be oxidised

The anomeric carbon is the only residue that can be oxidised on these sugars

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4
Q

Which disaccharides are reducing sugars and which aren’t?

A

Maltose & Lactose are reducing sugars

Sucrose is not a reducing sugar, as it does not have an anomeric C1 that can be oxidised

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5
Q

What is the difference between heteropolysaccharides and homopolysaccharides

A

Homopolysaccharides have one monomeric species

Heteropolysaccharides have more than one monomeric species

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6
Q

What 2 types of glucose polymers make up starch

A

Amylose

Amylopectin

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7
Q

What is the difference between amylose and amylopectin

A

Amylose is straight chained and has a(1-4) linkages

Amylopectin is more abundant, and is branched.
It has a(1-6) bonds every 24 - 30 residues

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8
Q

How is glycogen different from starch?

A

Glycogen is more extensively branched than starch (amylopectin)

Much higher ‘energy density’ than starch

Glycogen is used in animals, starch is used in plants

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9
Q

Why is glycogen (and starch) an effective energy storage molecule?

A

1) Compact - lots of glucose can be stored in a small volume
2) Branched - many non-reducing ends means it can be degraded/synthesised quickly to release/store energy
3) Insoluble - osmotically inactive so does not interfere with osmotic activity

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10
Q

What are glycoproteins?

A

Class of proteins which have carbohydrate groups attached to the polypeptide chain

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11
Q

What effects can adding a carbohydrate to a protein have?

A

Increase solubility

Influence conformation/shape

Protect it from degradation

Act as communication between cells

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12
Q

What are Glycosaminoglycans?

also called mucopolysaccharides

A

Un-branched polymers

Repeating units of hexuronic acid and an amino-sugar, which alternate through the chains

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13
Q

Where are glycosaminoglycans mainly found?

What does this indicate about their properties?

A

Mucus and in synovial joints

Lubricant properties as chains easily slide over each other

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14
Q

What are proteoglycans?

A

A compound consisting of a protein bonded to mucopolysaccharide groups, present especially in connective tissue

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15
Q

What is the difference between glycoproteins and proteoglycans?

A

Glycoproteins are proteins with carbohydrates attached

Proteoglycans are GAG’s with proteins bonded to them

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16
Q

What is the group of genetic disorders associated with glycosaminoglycans?

A

Mucopolysaccharidoses

Absence/malfunction of enzymes required for the breakdown of glycosaminoglycans/mucopolysaccharides

17
Q

What general health problems are associated with mucopolysaccharidoses

A

GAG’s build up in connective tissue, blood and other tissues

Can cause:

  • dementia
  • heart problems
  • inflammation to joints
  • stunting of bones
  • damage to endothelial structures
18
Q

Where is most glycogen stored?

A

Liver and skeletal muscle

19
Q

What is the difference between how glycogen is broken down in the liver and skeletal muscle?

A

In liver, glycogen is sequentially broken down into Glucose-6-phosphate, which is then dephosphorylated by G-6-phosphotase before entering the blood

In skeletal muscle, there is no G-6-phosphotase, so after glycogen is broken down to G-6-P, it undergoes glycolysis (substrate level phosphorylation) and forms lactate

20
Q

What disease is characterised by Glucose-6-phosphotase deficiency in the liver, kidney and intestines

This disease shows symptoms such as high liver [glycogen], fasting hypoglycaemia and lacticacidaemia (high blood [lactate])?

A

Von Gierke’s disease

21
Q

What disease is characterised by Skeletal muscle phosphorylase deficiency

This disease will show symptoms in early adulthood, with high muscle [glycogen], weakness & cramps and no blood [glucose] increase after exercise?

A

McArdle’s disease

22
Q

What is glycolysis?

A

Sequential, cellular, anaerobic degradation of glucose, to produce pyruvic/lactic acid, yielding a relatively small amount of ATP

23
Q

What is the net energy product of glycolysis?

A

2 ATP and 2 NADH per glucose molecule

24
Q

What is redox balance, and why is it necessary in glycolysis?

A

NAD+ is necessary in glycolysis, but is limited in cells

Glycolysis uses up NAD+

All fates of pyruvate, produced from glycolysis will produce NAD+, thus regenerating it at the same rate that it is used up

Therefore, there is no net change in the amount of NAD+

25
Q

What are the two main fates of pyruvate produced from glycogen?

A

Aerobic conditions = conversion to Acetyl CoA then entry to Citric acid cycle

Anaerobic conditions = entry to Cori cycle = lactate

26
Q

What process converts Lactate to glucose?

A

Gluconeogenesis

27
Q

What is the Cori cycle?

A

Metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose, which then returns to the muscles and is metabolised

28
Q

In what conditions would the Cori cycle be relied upon?

A

Intense exercise such as sprinting

The body can’t supply cells with enough oxygen for oxidative phosphorylation

29
Q

Where does gluconeogenesis take place?

A

Liver

30
Q

What is gluconeogensis?

A

Metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactate, glycerol, and glucogenic amino acids

31
Q

What is the purpose of the ‘side step reactions’ in gluconeogenesis?

A

Avoids the irreversible reactions that take place in glycolysis

32
Q

What is the basic sequence of molecules in gluconeogenesis

A
Pyruvate 
Oxaloacetate 
PEP
G-3-P 
(DHAP)
F-1,6-P
G-6-P
Glucose
33
Q

What is the basic sequence of molecule products in glycolysis?

A
Glucose 
G-6-P
F-1,6-P
(DHAP)
G-3-P
PEP
Pyruvate
34
Q

In gluconeogenesis, where does the first side step reaction, in which Pyruvate is converted to PEP, largely take place?

A

Mitochondria

In the liver

35
Q

What is the pentose phosphate pathway?

A

Metabolic pathway which generates NADPH and pentose sugars, precursors for DNA/RNA synthesis from glucose

36
Q

What are the two phases of the pentose phosphate pathway?

A

Oxidative, irreversible phase: generates NADPH

Non-oxidative, reversible phase: generates precursors for nucleotides

37
Q

The pentose phosphate pathway produces NADPH

What is this used for?

A

‘Provides energy’ for fatty acid synthesis (anabolism)

38
Q

Describe how being drunk would inhibit gluconeogenesis

A

When the body breaks down and processes a lot of ethanol, the amount of NAD+ in your body drops

This leaves very little NAD+ available for gluconeogenesis

This means that gluconeogenesis cant take place, which can lead to hypoglycaemia and lacticacidaemia

39
Q

What are the 2 anabolic pathways in this brainscape

A

Gluconeogenesis

Pentose phosphate pathway - although this has some catabolic stages