Calcium and phosphate metabolism Flashcards

1
Q

What cells release PTH?

A

Chief cells

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2
Q

What triggers PTH release?

A

Low serum calcium

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3
Q

What are the actions of PTH?

A

Increases calcium absorption in the intestine by increasing calcitriol, increasing bone resorption, decreases phosphate reabsorption, increases calcium reabsorption

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4
Q

What is the main way of controlling calcium levels?

A

PTH

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5
Q

What cells release calcitonin?

A

Parafollicular cells

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6
Q

What triggers release of calcitonin?

A

High serum calcium

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7
Q

What is the action of calcitonin?

A

Decreases bone resorption to decrease serum calcium

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8
Q

What triggers FGF-23 release?

A

High serum phosphate, high serum PTH, high serum calcitriol, dietary phosphate loading

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9
Q

What cells release FGF-23?

A

Osteocytes

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10
Q

What is the action of FGF-23?

A

Decreasing 1-alpha-hydroxylation of vitamin D which decreases gut absorption of phosphate and decreases expression of Na transporter in the renal tubule which increases renal phosphate excretion

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11
Q

What is klotho transmembrane protein associated with?

A

FGF-23

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12
Q

What is the precursor to vitamin D?

A

7-Dehydrocholesterol

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13
Q

What is calcitriol?

A

Activated vitamin D

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