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Bacteriology II > Brucella (Exam 4) > Flashcards

Brucella (Exam 4) Flashcards

1
Q

What is the most common cause acute effects of Brucella in people?

A

needle sticks (recapping live-attenuated vaccines)

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2
Q

(T/F) Brucella is a zoonotic, gram-negative coccobacillus.

A

True

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3
Q

Brucella is a(n) (obligate/facultative) (intracellular/extracellular) bacterium.

A

facultative intracellular

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4
Q

What family is Brucella a part of?

A

Rhizobiales

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5
Q

Brucella LPS inactivates:

A

complement

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6
Q

Which secretion system does Brucella use to infect the host cells?

A

Type IV (survive/replicate in phagocytes)

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7
Q

A virulence factor of Brucella is that it utilizes _________, a carbon source.

A

erythritol

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8
Q

(T/F) Brucella abortus, B. melitensis, and B. suis have different surface antigens, and therefore, do not cross-react on serology.

A

False (common surface antigens, do cross-react)

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9
Q

Brucella _______ is the only species which does NOT cross-react with the others.

A

canis

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10
Q

________ immunity is protective against Brucella while _______ immunity is not.

A

protective: cell-mediated
non-protective: humoral

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11
Q

(T/F) Human Brucellosis is a reportable disease.

A

True

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12
Q

Bovine Brucellosis is caused by Brucella _______.

A

B. abortus

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13
Q

B. abortus causes Bovine Brucellosis which is also called __________.

A

Bang’s Disease

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14
Q

What is the cardinal sign of Brucella abortus in female cattle?

A

abortion (3rd trimester)

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15
Q

(T/F) Non-pregnant females infected with B. abortus develop only mild clinical signs.

A

False (NO clinical signs)

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16
Q

(T/F) Males infected with Brucella abortus develop infertility.

A

False (NO clinical signs)

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17
Q

Which animals are the primary reservoir for Brucella abortus?

A

female cattle carriers

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18
Q

B. abortus is primarily transmitted via:

A

ingestion (infected uterus, placenta, aborted material)

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19
Q

Apart from ingestion of infected reproductive materials, B. abortus transmission can occur through ________, which are an important reservoir for cattle that interact with them.

A

elk

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20
Q

(T/F) B. abortus can be vertically transmitted.

A

True

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21
Q

Infection by B. abortus occurs (before/after) the beginning of gestation.

A

after

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22
Q

Infection by B. abortus causes abortion by necrosis of fetal ________ and ________.

A

cotyledon
endometrium

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23
Q

Diagnosis of B. abortus is fully _________ dependent.

24
Q

Which two diagnostic tests detect IgG to diagnose B. abortus infection in cattle?

A

Card Test
Milk Ring Test

25
Q

All diagnostic testing for B. abortus is completed by ____________ diagnostic laboratory.

A

state / federal

26
Q

Which vaccine offers protective immunity against Brucella abortus infection?

A

RB51 vaccine

27
Q

Cattle vaccinated with RB51 vaccine (will/won’t) give a false positive result.

28
Q

Cattle given O-Antigen deficient B. abortus mutant (will/won’t) give a false positive result.

29
Q

(T/F) Cattle should be treated with tetracyclines after B. abortus diagnosis.

A

False (SHOULD NOT be treated!)

30
Q

Swine Brucellosis is caused by Brucella __________.

31
Q

(T/F) Brucella suis is a major problem in swine production in all US states.

A

False (free in domestic swine)

32
Q

Brucella suis is a major problem in _______ swine.

33
Q

The major clinical sign in B. suis infection is:

34
Q

Boars with B. suis are usually asymptomatic or have subclinical ________.

35
Q

Herd infertility is common in Brucella _______ infection but NOT in Brucella _______.

A

B. suis
NOT B. abortus

36
Q

List the 3 possible modes of transmission for B. suis.

A
  1. ingestion (primary)
  2. venereal (boar)
  3. inhalation
37
Q

(T/F) Vaccination is an appropriate method to control B. suis as it is with B. abortus.

A

False (no vaccination)

38
Q

(T/F) As with B. abortus, you should NOT treat for B. suis.

39
Q

The only satisfactory control method for Brucella suis is:

A

herd depopulation

40
Q

(T/F) Canine Brucellosis is reportable in all US states.

A

False (some states)

41
Q

Canine Brucellosis is caused by:

42
Q

(T/F) Brucella canis is zoonotic.

A

False (technically can but doesn’t normally infect humans)

43
Q

B. canis is __________ distinct from the rest of Brucella species.

A

antigenically

44
Q

B. canis causes abortion in females, as with the other species, but differs in that infected males can develop ________ & ________.

A

scrotal dermatitis
infertility

45
Q

10% of dogs infected with B. canis develop breakdown of the vertebral disc called:

A

discospondylitis

46
Q

Cell-mediate immunity can be protective against B. canis, and therefore subsequent litters are:

47
Q

What 2 other bacteria causes similar signs in the female as B. canis, seen as differential diagnoses?

A

beta-hemolyic Streptococcus
E. coli

48
Q

RSAT and 2-ME-RSAT Card Tests serology are used ONLY as ________ serology tests for Brucella canis.

49
Q

What antigen is used in B. canis screening tests that has high cross-reactivity with B. canis?

A

Brucella ovis

50
Q

Which test is more specific for diagnosis and uses an antigen from B. canis?

A

Tube Agglutination Test

51
Q

Agar Gel Immunodiffusion Test (AGID) uses _________ protein antigens to test for B. canis.

A

cytoplasmic

52
Q

What is the ONLY reliable means to specifically establish presence of Canine Brucellosis?

53
Q

(T/F) Combined antibiotic therapy is recommended to treat Canine Brucellosis.

54
Q

Canine Brucellosis is treated with (short/long) term antibiotics and for what duration?

A

longterm
4-6 weeks

55
Q

(T/F) Treatment eliminates Canine Brucellosis infection.

A

False (carriers)

56
Q

(T/F) There is NO vaccination for Canine Brucellosis.

57
Q

Humans are usually (sensitive/resistant) to Canine Brucellosis.

Bacteriology II (22 decks)

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