Breast Pathology Flashcards
What percentage of breast cancers have micro-calcifications?
50%
False negative mammogram rate?
30%
Older or younger women have higher incidence for false negatives on mammograms?
younger. Younger women have denser more sclerotic breasts. Often harder to see things
Accessory breast tissue in the axillary fossa. Tumors may develop here and they may be confused with:
Axillary lymph nodes and/or mets
Ectopic breast tissue
may develop along mammary ridge to involute
Macromastia
Excessive breast tissue
Nipple inversion
associated with large pendulous breasts. May be confused with cancer
Supernumerary breasts/nipples
persistent epidermal thickenings along milk line from axilla to perineum
Fibrocystic change/ disease
- Considered a hyperplastic Disorder
- Women 25-45 (related to hormone imbalance… up and down Estrogen and Progesterone) KNOW
- Increased mitotic and apoptotic rate
- May hamper mammography
Sclerosing adenosis
- Proliferation of glandular tissue
- Risk of Cancer of 1.5- 2x normal
- Clustered microcalcifications
- If it is palpable what do you call it? adenosis tumor
- retains both cell layers!!! retains lobular architecture!!!
Atypical ductal hyperplasia
- Features are suggestive but not diagnostic of DCIS
- Increased risk of cancer 2-5x
- Risk is equal in both breasts
- enlarged nuclei and nucleoli, progressive loss of nuclear polarity
Cancer risk increase in Atypical ductal hyperplasia?
Yes. 2- 4x5 times. Risk is equal in both breasts
Atypical lobular hyperplasia
Resembles Lobular Carcinoma in situ but DOES NOT FILL OR DISTEND 50% or MORE ACINI WITHIN A LOBULE.,
- Still, 4-5x the risk of CA in both breasts, greater risk in pre-menopausal pts
Cancer risk increased in atypical lobular hyperplasi
yes. 4-5 times
Most common benign breast tumor
Fibroadenoma
- Typical in younger women
- MOVES AROUND …like a marble
- Malignant transformation risk… less than .1%
- Hormonally responsive and may grow in pregnancy
KNOW
What is fibroadenomatosis
mulitifocal disease in post renal transplant patients and with EBV in the immunosuppresed
What happens to fibroadenomas during pregnancy
they may grow, they can be hormonally responsive
Phyllodes tumor
Fibroadenoma like tumor with overgrowth of the fibrous part. characteristic leaf like projections on biopsy