Bone Marrow Flashcards
What are the two types of bone marrow?
Red and yellow
What is done in red marrow?
Site of blood cell formation in adults
What is yellow marrow?
Mostly adipose tissue that can change to red marrow when necessary for hemopoiesis
Where is red marrow found?s
Found mainly in cancellous bone of flat bones and vertebrae
What are blood cells formed from?
Stem cells- pluripotental cells located in bone marrow (myeloid tissue) or lymphatic tissue (in the case of some lymphocytes)
What cells spend their entire working lives within blood vasculature?
Erythrocytes and platelets (thrombocytes)
What are the stages of leukocyte development?
- Stem cells
- Progenitor cells
- Precursor (blast) cells
- Mature cells
What are the possible myeloid stem cell potential cells?
(Grannies excercise because many expire)
- Granulocyte- macrophage CFU
- Eosinophils CFU
- Basophil CFU
- Megakaryocyte CFU
- Erythroid CFU
What does a mono blast become? (From Granulocyte-macrophage CFU)
Monocytes -> macrophage
What does a myeloblast become?
- neutrophil
- Eosinophil
- Basophil -?> Mast cell
What does a megakaryoblast become?
Megakaryocyte which makes platelets
What two lineages can a Granulocyte-macrophage CFU become?
Monoblast
Myeloblast (only for neutrophil)
Where do T-cells mature?
Thymus gland
What are the development stages of erythrocytes? (Know 1,5 and 6)
- Proerythroblast
- Basophilic erythroblast
- Polychromatophilic erythroblast
- Orthochromatic erythroblast (normoblast)
- Reticulocyte
- Mature erythrocyte
What are the development stages of granulocytes? (Know 1,2,6)
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band cell
- Mature leukocyte
