Blood Vessels Flashcards
types of blood vessels (and diameters)
elastic arteries (1 - 2.5cm) muscular arteries (0.3 mm - 1 cm) arterioles (10 um - 0.3 mm) capillaries (8 - 10 um) venules (8 - 100 um) veins
layers of arteries
lumen - blood filled inner space
tunica intima
tunica media
tunica externa
tunica intima
endothelium made up of simple squamous epithelium
subendothelial layer
internal elastic membrane
tunica media
sheets of smooth muscle and elastic fibers
external elastic membrane
contraction causes vasoconstriction, relaxation causes vasodilation
tunica externa
composed of collagen fibers
elastic arteries
for conducting blood
largest arteries
diameter 1-2.5 cm
high elastin content: dampens surge of blood pressure
walls of vessels supplied by vasa vasorum
proximal to muscular arteries
muscular arteries
for distributing blood
lie distal to elastic arteries
diameter 0.3 mm - 1 cm
tunica media is thick, smooth muscle and elastin fibers
unique feature: internal and external elastic membranes that dampen the pulsatile pressure produced by the heartbeat
arterioles
smallest arteries
diameters 10 um - 0.3 mm
larger arterioles possess the same tunics
diameter of arterioles controlled by: local factors in the tissues, autonomic nervous system
capillaries
smallest blood vessels
diameter 8 - 10 um
red blood cells pass through single file
site specific functions
site-specific functions of capillaries
lungs: oxygen enters blood, carbon dioxide leaves blood
other tissues: oxygen leaves blood, carbon dioxide enters blood
small intestines: receive digested nutrients
endocrine glands: pick up hormones
kidneys: remove nitrogenous and other wastes
poorly vascularized tissues
tendons and ligaments are poorly vascularized
epithelia and cartilage are avascular
precapillary sphincters
regulate the flow of blood to tissues
when relaxed, sphincters are open and blood flows to true capillaries
when constricted, sphincters are closed and blood flows to metarteriole thoroughfare channel and bypasses the capillaries
types of capillaries
continuous capillaries - the least permeable type of capillaries
fenestrated capillary - large fenestrations (pores) increase permeability in small intestines and kidneys
sinusoidal capillary - most permeable with wide intercellular clefts in bone marrow, liver, and spleen
continuous capillaries
most common type
relatively low permeability
found in skin, muscle, blood-brain barrier
capillaries have complete tight junctions of endothelial cells which prevent movement
vital molecules pass through via highly selective transport mechanisms (endothelial cell membranes and pinocytotic vesicles)
not a barrier against: oxygen, carbon dioxide, some drugs
where are continuous capillaries found?
skin, muscle, blood-brain barrier
pericytes around continuous capillaries
contractile cells that wrap around endothelial cells, embedded in basement membrane
communicate with and help sustain endothelial cells
fenestrated capillaries
large fenestrations (pores) result in increased permeability found in kidneys and small intestines
sinusoidal capillaries
most permeable capillaries wide open intercellular clefts (gaps of unjoined membrane through which small molecules can enter and exit) usually also fenestrated incomplete basement membrane have a large diameter and twisted course found in bone marrow, liver, and spleen
where are fenestrated capillaries found?
small intestine, kidneys
where are sinusoidal capillaries found?
liver, bone marrow, spleen
routes of permeability in capillaries
- endothelial cell membranes
- pinocytotic vesicles
- fenestrations (fenestrated capillaries)
- intercellular clefts (sinusoidal capillaries)
smallest venules are called
postcapillary venules
thickest tunic in veins
tunica externa
rich in collagen fibers
mechanisms to move venous blood
valves - in some valves, prevent backflow of blood, particularly in limbs
skeletal muscles - press against vein walls and help pump blood toward the heart