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Bmsc207 > blood 2 > Flashcards

blood 2 Flashcards

1
Q

whats the second most abundant white blood cells

A

lymphocytes

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2
Q

do plates have nucleus

A

no

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3
Q

what are considered to be not true cells

A

platelets

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4
Q

what is a mogakaryote

A

organism that produces platelets

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5
Q

whats the lifespan of platelets

A

about 10 days

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6
Q

what are the two types of granules in platelets

A

dense core granules
a-granules

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7
Q

what cell is very important in hemostasis

A

platelets

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8
Q

what is hemostasis

A

the prevention of blood loss from a damaged vessel

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9
Q

whats the three step process to hemostasis

A

vasoconstriction
platelets plug formation
clot (coagulation cascade)

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10
Q

how do platelets attach to the vessel wall

A

their cell surface receptors

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11
Q

what are platelet cell surface receptors activated by

A

collagen and laminin that get exposed when a cut happens

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12
Q

when does the release of platelet factors happen

A

after they’ve bonded to their receptors

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13
Q

what is platelet formation an example of

A

positive feedback loop

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14
Q

what do intact endothelial cells do

A

they release substances to prevent activated platelets from binding

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15
Q

what causes platelets to form molecular bridges between one another

A

von willebrand factor

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16
Q

what stabilizes the the platelet plug into a clot

A

a fibrin protein mesh

17
Q

what initiates the intrinsic pathway

A

factor XII (12)

18
Q

what ends the intrinsic pathway

A

activated factor X (10)

19
Q

what starts the extrinsic pathway

A

factor VII (7)

20
Q

what ends the intrinsic pathway

A

active factor X (10)

21
Q

what happens to b both active factor 10 created

A

they converge into the same pathway known as the common pathway

22
Q

what does the common pathway produce

A

prothrombinase

23
Q

what does prothrombinase convert

A

prothrombin to thrombin

24
Q

what is thrombin

A

a central protease of the coagulation cascade

25
Q

what forms the gel that weaves through plug and traps blood cells

A

fibrin

26
Q

what does thrombin convert

A

fibrinogen to a stable fibrin clot

27
Q

what is hemophilia

A

a name given to diseases where the coagulation cascade is defective or lacking

28
Q

what is hemophilia a

A

factor VIII deficiency

29
Q

what is hemophilia B

A

factor IX deficiency

30
Q

can too much anticoagulation be bad

A

yes

31
Q

what is fibrinolysis

A

the breakdown of blood clots

32
Q

what breaks down stable fibrin and fibrinogen

A

plasmin

Bmsc207 (27 decks)

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