blood 1 Flashcards

1
Q

how much of blood is plasma

A

3 L

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2
Q

what is blood

A

a connective tissue composed of cellular elements suspended in a fluid matrix

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3
Q

whats the primary difference between plasma and the interstitial fluid

A

plasma proteins

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4
Q

whats the most abundant type of plasma proteins

A

albumins

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5
Q

what are albumins good for

A

they are good carriers for various substances

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6
Q

how much blood does cellular elements take up

A

2L

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7
Q

whats the most abundant cellular element

A

erythrocyte

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8
Q

what c causes filtration

A

hydrostatic pressure

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9
Q

whats our normal blood volume

A

5L

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10
Q

which sex has more blood ? how much?

A

males have more with about 80ml/kg

females have about 70ml/kg

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11
Q

what causes the difference in volume of blood between sexes?

A

its usually a difference in red blood cell numbers

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12
Q

what are the three components of blood

A

hematocrit
buffy coat
plasma

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13
Q

what is one way clinicians look if you have a disease

A

look at the hematocrit layer

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14
Q

what is the hematocrit

A

volume occupied by RBCs

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15
Q

what is the buffy coat layer

A

WBC and platelets

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16
Q

what is the plasma layer

A

plasma proteins
electrolytes
lipids

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17
Q

which layer takes up the most space

A

plasma with 60%

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18
Q

what is hematopoiesis

A

production of blood cells

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19
Q

where does it happen in adults

A

pelvis, spine, ribs, cranium, and proximal end of long bones

20
Q

where does hematopoiesis happen?

A

in bone marrow

21
Q

what are the cells produced the most (75%)? why?

A

WBCs - they have a very short lifespan

22
Q

what can hematopoiesis stem cells do

A

specialized stem cells that are capable of regenerating themselves and then transform into basically any cell

23
Q

how long to RBCs normally last

A

about 4 months

24
Q

what is hemopoiesis guided by

A

cell signalling molecules (cytokines)

25
what is the cytokine involved in the production of red blood cells
erythropoietin
26
what is the cytokines involved in making thrombocytes
thrombopoietin
27
what is the cytokine involved in making WBC
colony stimulating factors
28
what is RBC production called
erythropoiesis
29
whats the most abundant cell type in the blood
erythrocytes
30
what are RBC's major tasks
carrying O2 from lungs to systemic tissue carrying CO2 from the tissues to the lungs assisting in the buffering of acids and bases
31
what can the shape of RBC tell us
disease
32
what is hemoglobin
oxygen carrying protein in RBC
33
what do RBCs mainly consist of
hemoglobin
34
how many oxygen can 1 heme group carry
1
35
how many oxygen can 1 hemoglobin carry
4 O2
36
where is 70% of iron in the body found
heme groups of haemoglobin
37
what does hemoglobin synthesis require
iron
38
what do WBC do
defend against infection
39
what are the two kinds of wbcs
granulocytes non granule containing lymphocytes and monocytes
40
what are the 3 granulocytes
neutrophiles eosinophils basophils
41
whats the most abundant leukocyte
neutrophils
42
what are the non granule containing lymphocytes and monocytes
lymphocytes (T cells and B cells) monocytes
43
what immunity are lymphocytes a part of
adaptive immunity
44
T cells do what immunity
cell mediated immunity
45
B cells do what immunity
Humoral immunity
46
what do eosinophils release
major basic protein