block e lecture 2

Question 1

how much cholesterol is synthesised

Answer 1

75%

Question 2

where is cholesterol primarily synthesised

Answer 2

liver
cytoplasm and ER

Question 3

what reaction of cholesterol is rate limiting

Answer 3

HMG-CoA reductase

Question 4

some functions of cholesterol

Answer 4

cell membranes
sex hormones
vit D

Question 5

what are the dangers of high cholesterol levels

Answer 5

atherosclerosis
increase coronary heart disease risk
heart attack
angina
stroke
PVD

Question 6

5 types of lipoproteins

Answer 6

-chylomicrons
-VLDL
-IDL
-LDL
-HDL

Question 7

what does VLDL stand for

Answer 7

very low density lipoproteins

Question 8

what does IDL stand for

Answer 8

intermediate density lipoproteins

Question 9

what does LDL stand for

Answer 9

low density lipoproteins

Question 10

what does HDL stand for

Answer 10

high density lipoproteins

Question 11

what do statins inhibit

Answer 11

early and rate limiting step in cholesterol biosynthesis
hepatic cholesterol synthesis results in increased expression of the LDL recep gene

Question 12

what are statins documented in reducing

Answer 12

fatal and non fatal CHD events
strokes
total mortality

Question 13

2 adverse effects on triglycerides and lipoprotein levels

Answer 13

hepatotoxicity
myopathy