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pharmacology bm213 > block d lecture 2 > Flashcards

block d lecture 2 Flashcards

1
Q

3 subdivisions of non peptide neurotransmitters

A

monoamines
aa
others

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2
Q

3 subdivisions of non peptide neurotransmitters

A

monoamines
aa
others

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3
Q

key criteria for ID of a substance as a neurotransmitter

A

synthesised within a neuron
stored in nerve terminal
released by nerve stimulation in Ca dependent manner

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4
Q

is dopamine a neurotransmitter

A

yes

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5
Q

what do neurotransmitters need specific mechanisms for

A

inactivation

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6
Q

what do neurotransmitters mimic

A

exogenously applied substances mimic endogenous response to neurotransmitter

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7
Q

what to antagonists inhibit in relation to neurotransmitters

A

antagonist inhibits both neurotransmitter and exogenously applied substance

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8
Q

physiological functions of noradrenaline

A

reward system and mood
state of arousal
blood pressure regulation

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9
Q

physiological functions of dopamine

A

motor control
rewaard system, mood
motivation, prolactin secretion

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10
Q

physiological functions of 5HT

A

sleep, wakefullness, temperature regulation
mood

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11
Q

physiological functions of acetylcholine

A

arousal
learning
motor control

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12
Q

physiological functions of glutamate

A

memory
epilepsy
relay of sensory info

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13
Q

physiological functions of GABA

A

anxiety
epilepsy

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14
Q

how many aa long are neuropeptides

A

5-30

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15
Q

3 similarities between neuropeptides and classical neurotansmitters

A

stored in vesicles
Ca dependent release
effect secnond messengers and therefore ion channel activity

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16
Q

some differences between neuropeptides and classical neurotransmitters

A

-transported to terminal
-processed to active peptide
-synthesised in cell body
-released at lower concs
-longer action

17
Q

examples of GPCR

A

dopamine
NA
5HT
ACh- muscarinic

18
Q

what type of transmission is GPCR

A

slow neurotransmission

19
Q

how is fast neurotransmission achieved

A

receptor operated ion channels

20
Q

examples of fast neurotransmisson

A

nicotinic ACh recep
glutamate ionotropic recep
P2X recep

20
Q

examples of fast neurotransmisson

A

nicotinic ACh recep
glutamate ionotropic recep
P2X recep

21
Q

in fast neurotransmission what is role of Na, K

A

Excitatory
Post
Synaptic
Potential

pharmacology bm213 (16 decks)

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