block d lecture 2 Flashcards
3 subdivisions of non peptide neurotransmitters
monoamines
aa
others
3 subdivisions of non peptide neurotransmitters
monoamines
aa
others
key criteria for ID of a substance as a neurotransmitter
synthesised within a neuron
stored in nerve terminal
released by nerve stimulation in Ca dependent manner
is dopamine a neurotransmitter
yes
what do neurotransmitters need specific mechanisms for
inactivation
what do neurotransmitters mimic
exogenously applied substances mimic endogenous response to neurotransmitter
what to antagonists inhibit in relation to neurotransmitters
antagonist inhibits both neurotransmitter and exogenously applied substance
physiological functions of noradrenaline
reward system and mood
state of arousal
blood pressure regulation
physiological functions of dopamine
motor control
rewaard system, mood
motivation, prolactin secretion
physiological functions of 5HT
sleep, wakefullness, temperature regulation
mood
physiological functions of acetylcholine
arousal
learning
motor control
physiological functions of glutamate
memory
epilepsy
relay of sensory info
physiological functions of GABA
anxiety
epilepsy
how many aa long are neuropeptides
5-30
3 similarities between neuropeptides and classical neurotansmitters
stored in vesicles
Ca dependent release
effect secnond messengers and therefore ion channel activity
some differences between neuropeptides and classical neurotransmitters
-transported to terminal
-processed to active peptide
-synthesised in cell body
-released at lower concs
-longer action
examples of GPCR
dopamine
NA
5HT
ACh- muscarinic
what type of transmission is GPCR
slow neurotransmission
how is fast neurotransmission achieved
receptor operated ion channels
examples of fast neurotransmisson
nicotinic ACh recep
glutamate ionotropic recep
P2X recep
examples of fast neurotransmisson
nicotinic ACh recep
glutamate ionotropic recep
P2X recep
in fast neurotransmission what is role of Na, K
Excitatory
Post
Synaptic
Potential
