block c lecture 1 Flashcards

endocrine physiology

1
Q

2 main types of hormones

A

-chemically (peptide vs steroid)
-functionally (short term vs long term regulation of function)

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2
Q

example of a peptide hormone

A

insulin

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3
Q

how are the chains joined in peptide hormones

A

disulphide bridges

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4
Q

what does the nature of the aa at each point in peptide hormones affect

A

affects ability of this to occupy a receptor and elicit a response in a whole tissue

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5
Q

2 examples of steriod hormones

A

cortisol
testosterone

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6
Q

what are steroid like hormones

A

longer acting hormones

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7
Q

example of a steroid like hormone

A

thyroxine

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8
Q

onset, offset, and secretion of peptide hormones

A

rapid onset
rapid offset
secreted in bursts when required

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9
Q

onset, offset, and secretion of steroid type hormones

A

slow onset
slow offset
secreted to maintain constant plasma hormone concentration

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10
Q

examples of short term regulation in peptide hormones

A

glucose
water
calcium

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11
Q

when are peptide hormone secretions terminated

A

when desired physiological correction achieved

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12
Q

what is T1D

A

islets of langerhans are destroyed (autoimmune)

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13
Q

what is T2D

A

response to insulin fails in the body, doesnt effect the tissues the way it should

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14
Q

what does glucagon do to glucose concentration

A

raise glucose conc

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15
Q

what does insulin do to glucose concentration

A

decreased glucose conc

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16
Q

what occurs to BGL after someone has a meal

A

bgl increases

17
Q

what does the increase of insulin release promotes

A

glucose into the cell

18
Q

what is glycogen

A

longer term store carb

19
Q

what does the increase in glucagon release do

A

brings about release of glycogen stores in lover
restoring glucose conc

20
Q

what is Ca important for

A

cell signalling

21
Q

what hormone raises blood conc of Ca2

A

parathyroid hormone

22
Q

what cells produce PTH

A

parathyroid cells

23
Q

once physiological level os Ca is reached what occurs

A

PTH hormone is reduced too

24
Q

where do you typically see great exertions in hormone level bar

A

menstrual cycle and cortisol response

25
Q

what hormone does the thyroid produce

A

thyroxine

26
Q

what hormone does the adrenal cortex produce

A

cortisol

27
Q

what hormones do the gonads produce

A

sex hormones

28
Q

what does IGF-1 stand for

A

insulin growth factor 1

29
Q

where are hypothalamic hormones secreted

A

into median eminence

30
Q

how do hypothalamic hormones reach the anterior pituitary to control its secretion

A

blood vessels have capillairies at either end coming down into the lobe and will affect secretory activities

31
Q

what does TRH stand for

A

thyrotrophin releasing hormone

32
Q

what does CRH stand for

A

corticotrophin releasing hormone

33
Q

what does GH-RH stand for

A

growth hormone releasing hormone

34
Q

what does Gn-RH stand for

A

gonadotrophins releasing hormone

34
Q

what does Gn-RH stand for

A

gonadotrophins releasing hormone

35
Q

what does the hypothalamus also secrete

A

inhibitory factors

36
Q

what is CRH perceived by

A

higher brain centres

37
Q

what does stress cause

A

a marked increase in cortisol secretion

38
Q

what are peptide hormones controlled by

A

blood constituent