Bipolar Flashcards

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1
Q

What is ICD-10 definition of bipolar?

A
  • 2 + episodes of mood disturbances (depression, mania)

- At least 1 episode has to have been mania/hypomania

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2
Q

What are the two DSM 5 definition for bipolar?

A

-Bipolar 1 – 1 episode of mania
(may be followed by episode of
depression/hypomania)

-Bipolar 2 - at least one hypomanic episode and at least one major depressive episode

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3
Q

Describe mania

A
  • Symptoms must be present for at least 7 days or less if admission to hospital
  • Period of abnormally & persistently elevated, expansive or irritable mood with 3+ characteristic symptoms of mania
  • The disturbance must cause impairment to occupational or social function.
  • Can have psychotic features
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4
Q

What are symptoms of bipolar?

A
  • elevated mood
  • increased energy
  • increased self esteem
  • psychotic symptoms
  • easily distracted
  • risky behaviour
  • behavioural manifestations
  • Disruption to work/family/social life
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5
Q

What are psychotic symptoms of mania?

A
  • Grandiose delusions
  • Suspiciousness – can turn into persecutory delusions
  • Pressured speech so severe unable to understand
  • Irritable behaviour -> violent behaviour
  • Catatonic behaviour
  • Complete loss of insight
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6
Q

Describe criteria for hypomania

A

-Symptoms must be present for at least 4 days

-Similar to mania symptoms
But milder
No psychotic symptoms
Functioning not markedly impaired

  • If requires hospital admission -> Mania
  • If only hypomania: Bipolar Type II
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7
Q

What is criteria for depression?

A
  • Five (or more) of the following symptoms have been present during the same 2-week period
  • at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure
  • low mood
  • weight loss
  • insomnia
  • fatigue
  • loss of energy
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8
Q

What is definition of mixed episode

A

-When you have both manic/hypomanic and depressive symptoms in a single episode, present everyday for at least 1 week (DSM) or 2 weeks (ICD)

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9
Q

What are typical presentations of mixed episode?

A
  • Depression + overactivity/pressured speech
  • Mania + agitation and reduced energy
  • Low mood + other manic symptoms
  • Fluctuation between mania and depression
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10
Q

What is epidemiology for bipolar?

A
  • 1.3 million people in the UK have bipolar
  • prevalence is 1% to 2%
  • M:F = 1:1
  • Onset usually late adolescence/early adulthood but can occur at any age
  • Bipolar increases an individual’s risk of suicide by up to 20 times
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11
Q

How likely are you to develop bipolar disorder if your first degree relative had it?

A

-7x more likely (5-10%)

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12
Q

What are chances of developing psychiatric illness if parent had bipolar?

A

-50%

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13
Q

Describe course of illness for bipolar

A
  • Variable by person
  • First episode can be hypomania, mania or depression
  • Can have many years between first episode and second
  • Often 5-10 year interval between onset of illness and getting help
  • Manic episodes shorter than depressive if untreated (6 vs. 11 weeks)
  • Rapid cycling (>4/yr)
  • Gap between episodes shortens with progression
  • Pregnancy (>50% chance of relapse)
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14
Q

What 3 social factors affect BD?

A
  • Employment
  • Social isolation
  • The family
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15
Q

What is relationship between bipolar and employment?

A

-Rates of positive screening for bipolar disorder are higher in unemployed people, in those receiving particular benefits, and in people living alone.

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16
Q

How can isolation contribute to bipolar disorder?

A
  • Patients may become socially withdrawn during depressive episodes
  • Reckless behavior may impact on relationships leading to reduced social support
  • Long periods in hospital may lead to breakdown of friendships
17
Q

How can family issues affectBD?

A
  • Financial distress
  • Strained relationships, increased divorce rates
  • Social isolation
  • Development of mental health difficulties in other members of the family
18
Q

What investigations are done to diagnose BD?

A
  • Physical examination – exclude physical illness first

- Full set bloods

19
Q

What are the other differential diagnosis for bipolar?

A
  • Mania

- Depression

20
Q

What are the three phases of BD to consider when doing treatment?

A
  • BPAD Depression
  • Acute mania
  • Mood stabilisation
21
Q

What is treatment options for bipolar depression?

A
  • If severely depressed/suicidal/urgent can use ECT
  • Lithium
  • Valproate
  • Anti-psychotic eg quetiapine
  • Anti-convulsant eg lamotrigine
  • SSRIs - fluoxetine and olanzapine
  • psychological therapy
22
Q

What is treatment options for acute mania?

A
  • Lithium – response rate of around 80% but takes up to 2 weeks to take effect.
  • Valproate
  • Antipsychotic – good in acute behavioural disturbance eg olanzapine, quetiapine, risperidone, haloperidol
  • BDZ – used to help with sedation whilst waiting for above to work
  • ECT (catatonia/prolonged or severe manic episode) – good evidence, seldom used. Pregnancy and breastfeeding
23
Q

What is the purpose of maintenance?

A

-Prevention of recurrent episodes

24
Q

What is the first line of maintenance treatment?

A

-Lithium

25
Q

What are psychological treatments for bipolar?

A
  • CBT
  • Family therapy
  • Psychoeducation
  • Support Groups
26
Q

What is meant by renal therapeutic index for lithium?

A
  • Narrow
  • there is only a small difference between the minimum effective concentrations and the minimum toxic concentrations in the blood
27
Q

How is lithium removed from the body?

A

-Exclusive renal excretion

28
Q

What are side effects for lithium?

A
  • weight gain, fine tremor, lethargy and skin problems
29
Q

What is meant by lithium toxicity?

A
  • lithium overdose
  • coarse tremor
  • dehydration
  • confusion
  • drowsiness
30
Q

What are poor prognostic factors for bipolar?

A
  • poor employment
  • alcohol abuse
  • depression
  • male
  • psychotic features
31
Q

What are good prognostic factors for bipolar?

A
  • later onset
  • short episodes of mania
  • fewer sucidal thoughts
  • good treatment response
  • fewer psychotic symptoms
32
Q

What are triggers of relapse in BD?

A
  • non-concordance
  • illicit drug use
  • lack of sleep
  • increased stress (bereavement and exams)
33
Q

What are risks for having BPAD?

A
  • Suicide
  • unintentional self injury
  • financial risk
  • sexual risk
  • violent risk
  • arson