Biological membranes Flashcards
Cholestrol
- present to make the membrane more rigid and reduce the lateral movement of the
phospholipids.
-prevents the leakage of water and dissolved ions from the cell as it is very hydrophobic.
Intrinsic proteins
These may be integrated throughout the membrane. Intrinsic proteins
- include carrier proteins which allow
substances to cross the membrane.
Extrinsic proteins
On the surface of the membrane
Proteins
present to aid movement across the membrane, provide mechanical support and act in conjunction with glycolipds as receptors.
Glycolipds
- These are made up of a carbohydrate that is bound to lipids.
- These extend from the surface of the cell
- acts as a cell surface receptors for certain molecules.
- They also allow cells to adhere to one another to form tissues.
Glycoproteins
- These are carbohydrates that attach to extrinsic proteins and acts a cell surface receptors and
neurotransmitters. - These allow cells to recognise one another as well as attach to form tissues.
What is the main function of plasma membranes
Defines the borders of cells and most organelles.
-is selectively permeable. means that the membrane allows some materials to freely enter or leave the cell/organelle, while other materials cannot move freely.
The rate of gas exchange by diffusion becomes more rapid as:
- The surface area of the surface increases
- The diffusion distance decreases
- The diffusion gradient becomes more steep
- The temperature increases
Structure of a phospholipid
- consist of glycerol, two fatty acids, and a phosphate-linked head group.
- The hydrophilic phospholipid head faces outwards and the hydrophobic fatty acids faces inwards
Structure of cholestrol
a lipid that sits with phospholipids in the core of the membrane.
Thickness of phospholipid
The molecules arrange themselves into a bilayer which ranges from 5 to 10 nm in thickness.
What factors affect permeabiity of cells?
Temperature
pH
Solvent concentration
Permeability
How easy it is for substances to pass through
One type of mutation in the CFTR protein prevents the transport of chloride ions through the channel.
Which of the following is most likely to be observed in the lungs of patients with this mutation?
Sticky mucus with high electryote concentration
Why do phospholipids tend to spontaneously orient themselves into something resembling a membrane?
Phospholipids are amphipathic molecules. The polar head faced towards the water and the non polar fatty acid tails face towards other fatty acid tails