Benign Prostate Hyperplasia Flashcards
BPH is hyperplasia of what kind of tissue
glandular tissue
and hypertrophy of what
smooth muscle and glands
What is BPH
gradual periurethral enlargement around the urethra
what is the most prevalent risk factor
age
why is age the most prevalent risk factor
there is a change in the T:E ratio
what kind of change is occurring in the T:E ratio
there is a quantitive decrease in T and a relative increase with E
what are other Etiology of BPH
unclear, with a tie to diet, ethnicity, and genetic predisposition
the patho of BPH is related to what
to changed in testosterone, dihydrotestosterone, and estrogen
What converts T to DHT
5a reductase
what does E do
sensitizes the prostate to DHT
what does DHT do
promotes prostate growth and function
hyperplasia of the periurethral tissue causes what
compression against the urethra
hypertrophy of the smooth muscle cells causes what
impeded urine flow, and increase urine in the bladder
What are the histologic changes that are occurring
the bladder wall thickens and trebeculations and diverticula are forming to create more room for the urine
what is a complication that arises from this compensatory changes
urine stasis occurs = renal calculi and infections