Autoimmune Hepatitis Flashcards
1
Q
What is autoimmune hepatitis
A
severe chronic form of Hep
2
Q
Etiology
A
Environmental trigger: viral or chemicals
Defect in genetic component: HLA gene on Chr6
multi trait
3
Q
What are the two kinds of AH
A
Type 1 and type 2
4
Q
what does type 1 affect
A
more common in younger women
targets the antinuclear abs (nucleus of hepatocyte)
smooth muscle ab (ducts and vessels)
5
Q
what does type 2 affect
A
2-14 years of age
Abs against cytosol
and microsomes
6
Q
Manifestations
A
range from asymptomatic to manifestations of liver failure
7
Q
Diagnosis
A
exclude viral hep and other liver disease
there will be an increase in gamma globulins
8
Q
Treatment
A
suppress immune response liver transplant (if drugs don't work)
