AP 18 Nov Quizlet Flashcards
Measurement of blood flow through kidneys using PAH.
Renal Plasma Flow
Method to quantify renal plasma flow efficiency.
PAH Clearance
Regulates GFR via angiotensin II and nitric oxide.
Macula Densa
Glomerular filtration rate controlled by arteriole constriction.
GFR Regulation
Hormone that constricts afferent arterioles, affecting GFR.
Angiotensin II
Pump that facilitates sodium reabsorption in proximal tubule.
Sodium Potassium ATPase
Site for sodium and bicarbonate reabsorption.
Proximal Tubule
Process enhanced by sodium bicarbonate symporter.
Bicarbonate Reabsorption
Reabsorbs water and ions, crucial for concentration.
Loop of Henle
Reabsorbs sodium, potassium, and chloride ions.
Thick Ascending Limb
Medications that inhibit sodium potassium ATPase in nephron.
Loop Diuretics
Tissue that aids in concentrating tubular fluid.
Renal Interstitium
Process where kidneys reclaim water from filtrate.
Water Reabsorption
Enhanced by parathyroid hormone in distal tubule.
Calcium Reabsorption
Site for calcium and sodium reabsorption influenced by PTH.
Distal Tubule
Inhibit sodium-chloride reabsorption in distal tubule.
Thiazide Diuretics
Distal tubule responds to antidiuretic hormone.
ADH Sensitivity
Enhance potassium secretion and sodium reabsorption.
Aldosterone Receptors
Renal interstitium’s concentration affects urine concentration.
Osmolarity Effect
Enzyme aiding bicarbonate reabsorption in proximal tubule.
Carbonic Anhydrase
Facilitates sodium reabsorption and acid-base balance.
Sodium Hydrogen Exchanger
Movement of water and solutes into renal interstitium.
Bulk Flow
Facilitate water reabsorption in proximal tubule.
Aquaporins
Allow calcium entry in proximal tubular cells.
Calcium Channels
Regulates calcium levels and stimulates reabsorption.
Parathyroid Hormone (PTH)
Secretion of compounds like creatinine in proximal tubule.
Organic Compound Handling
Pump aiding calcium reabsorption in distal tubule.
Sodium-Calcium Exchanger
Cells in distal tubule responsive to ADH.
Principal Cells
Hormone regulating water reabsorption in kidneys.
ADH
Hormone increasing sodium reabsorption and potassium secretion.
Aldosterone
Aldosterone’s structure allowing cell membrane passage.
Cholesterol Derivative
Enzyme facilitating sodium reabsorption and potassium secretion.
Sodium-Potassium ATPase
Actual renal plasma flow adjusted for PAH clearance.
Effective Renal Plasma Flow
Molecule mediating afferent arteriole relaxation.
Nitric Oxide
Blood vessel supplying blood to glomerulus.
Afferent Arteriole
Blood vessel draining blood from glomerulus.
Efferent Arteriole
Rate of filtration in the kidneys.
GFR
Drugs relaxing blood vessels, increasing renal blood flow.
Calcium Channel Blockers
Receptors in proximal tubule responding to angiotensin II.
Angiotensin II Receptors
Transporter increasing sodium reabsorption in proximal tubule.
Sodium-Hydrogen Exchanger
Transporter moving sodium and bicarbonate simultaneously.
Sodium-Bicarbonate Symporter
Blood vessels reabsorbing substances from renal interstitium.
Peritubular Capillaries
Volume of blood passing through kidneys per minute.
Renal Blood Flow
Increases sodium reabsorption and constricts arterioles.
Angiotensin II Effects
Difference in sodium concentration across cell membrane.
Sodium Gradient
Proteins facilitating movement of substances across membranes.
Transporters
Pressure affecting filtration rate in glomerulus.
Glomerular Capillary Pressure
Mechanisms controlling kidney filtration and reabsorption.
Renal Function Regulation
Transports sodium out, potassium into cells.
Sodium-Potassium Pump
Process of reclaiming substances from filtrate.
Reabsorption
Substances reabsorbed between adjacent cells.
Paracellular Pathway
Substances pass through cell membranes.
Transcellular Pathway
Cellular connections regulating permeability.
Tight Junctions
Pressure driving fluid reabsorption, 10 mmHg.
Net Reabsorption Pressure
Water movement following solute concentration.
Osmosis
Waste product aiding water reabsorption.
Urea
Chloride follows sodium during reabsorption.
Chloride Reabsorption
Transport driven by sodium gradient.
Secondary Active Transport
Pressure at glomerular capillaries for filtration.
Filtration Pressure
Forces aiding fluid movement in capillaries.
Capillary Forces
Microvilli on proximal tubule cells enhancing absorption.
Brush Border
Process of reclaiming water from filtrate.
Fluid Reabsorption
Proteins facilitating substance movement across cells.
Transcellular Transporters
Concentration of solutes in renal interstitium.
Interstitial Concentration
Amount of solute affecting osmotic balance.
Solute Concentration
Movement of fluid influenced by pressure and concentration.
Fluid Dynamics
Segments of nephron involved in filtration and reabsorption.
Renal Tubules
Body’s water balance affecting renal function.
Hydration Status
Energy-dependent movement of substances against gradient.
Active Transport
Movement of substances down concentration gradient.
Passive Diffusion
Brush border increases surface area by 20-fold.
Surface Area Increase
Typical value of -70 mV in renal cells.
Membrane Potential
Driving force for sodium movement into proximal tubule cells.
Electrochemical Gradient
Typically negative, influenced by remaining ions.
Tubular Lumen Charge
Remains relatively constant along proximal tubule.
Sodium Concentration
Increases as sodium is reabsorbed in proximal tubule.
Chloride Concentration
Small amount of albumin filtered at glomeruli.
Protein Filtration
Approximately 1.8 grams per day in healthy kidneys.
Filtered Protein Amount
Proximal tubule reabsorbs about 1.7 grams daily.
Reabsorbed Protein Amount
Process of proximal tubular cells absorbing proteins.
Endocytosis
Alternative term for endocytosis in proximal tubular cells.
Pinocytosis
Products of protein breakdown reabsorbed in proximal tubule.
Amino Acid Reabsorption
Difference in concentration driving substance movement.
Concentration Gradient
Typically around -3 mV in proximal tubule.
Negative Charge in Lumen
Cells capable of generating membrane potential changes.
Electrically Excitable Cells
Minimal amounts filtered, typically not significant.
Filtered Albumin