AP 11 Nov Quizlet Flashcards
Blood pressure inside capillaries; 60 mmHg.
Capillary Pressure
Fluid pressure outside capillaries; 100 mmHg.
Hydrostatic Pressure
Regulates glomerular filtration rate (GFR) significantly.
Efferent Arteriole
Rate of filtration; 125 mls/min in healthy kidneys.
Glomerular Filtration Rate (GFR)
Kidney’s ability to maintain blood flow and GFR.
Autoregulation
Resistance in blood vessels; highest in efferent arteriole.
Vascular Resistance
Cells maintaining capillary structure and filterability.
Podocytes
Pressure due to proteins; initially 28 mmHg in glomeruli.
Oncotic Pressure
Calculated by subtracting oncotic and hydrostatic pressures.
Net Filtration Pressure
Process of reclaiming filtered substances; 99% reabsorbed.
Reabsorption
Removal of substances via urine; filtration minus reabsorption.
Excretion
Active transport of substances into the tubule.
Secretion
Space between tubules and blood vessels; facilitates reabsorption.
Renal Interstitium
Capillaries responsible for reabsorbing filtered fluid.
Peritubular Capillaries
GFR divided by renal plasma flow; about 0.19.
Filtration Fraction
Total blood flow to kidneys; about 1100 mls/min.
Renal Blood Flow
Normal output; about 1 mL/min, varies with blood pressure.
Urine Output
Adjusts blood flow to glomeruli; crucial for filtration.
Afferent Arteriole
Efferent arteriole constriction increases filtration rate.
Filtration Rate Adjustment
Pressure in renal interstitium; about 6 mmHg.
Physical Fluid Pressure
Protein osmotic pressure in tubule; initially zero.
Osmotic Pressure
Kidney adjusts fluid excretion for blood pressure control.
Long-term Blood Pressure Management
Effective between 50-150 mmHg in healthy kidneys.
Blood Pressure Range for Autoregulation
Compromised function in sick individuals; requires higher pressures.
Imperfect Autoregulation
Kidney adjusts urine output for maintaining fluid balance.
Fluid Balance
Plasma component of renal blood flow; about 660 mls/min.
Renal Plasma Flow
Low in peritubular capillaries; about 10 mmHg.
Net Reabsorption Pressure
Blood pressure in renal artery, approx. 100 mmHg.
Renal Artery Pressure
Blood pressure in glomerular capillaries, approx. 60 mmHg.
Glomerular Capillary Pressure
Pressure driving plasma filtration in kidneys.
Filtration Pressure
Typical value in systemic capillaries, 28 mmHg.
Plasma Oncotic Pressure
Pressure from proteins in tubule, typically zero.
Protein Osmotic Pressure
Process of filtering plasma through glomeruli.
Filtration Dynamics
Decrease in pressure due to vascular resistance.
Pressure Drop
Loss of fluid from glomerular capillaries during filtration.
Fluid Loss
Increase in protein concentration due to fluid loss.
Concentration of Proteins
Kidney’s role in regulating blood pressure over time.
Long-term Blood Pressure Control
Pressure opposing filtration from remaining proteins.
Colloid Osmotic Pressure
Manipulation of resistance to regulate blood flow.
Vascular Resistance Control
Difference in pressure driving blood flow.
Blood Pressure Gradient
Process of plasma passing through glomeruli.
Fluid Filtration
Behavior of blood flow in capillaries.
Capillary Dynamics
Range of pressures for effective blood flow regulation.
Renal Autoregulation Limits
Variations in pressure affecting renal function.
Pressure Changes
Pressure exerted by fluid in renal tubules.
Fluid Pressure in Tubule
Volume of fluid filtered per minute, 125 mL.
Filtration Rate
Constant used to calculate filtration rate, 12.5.
Filtration Coefficient (KF)
Glomerular filtration rate, influenced by efferent arteriole.
GFR
Process of separating substances from blood in kidneys.
Filtration
Physical pressure in tubules, measured at 18 mmHg.
Fluid Pressure
Increases upstream pressure, enhancing filtration.
Constricting Efferent Arteriole
Decreases glomerular pressure, reducing filtration rate.
Relaxing Efferent Arteriole
Pressure decreases from 60 mmHg to 18 mmHg.
Blood Pressure Drop
Cells lining tubules, involved in reabsorption.
Tubule Cells
Mechanisms for reabsorption, vary by tubule segment.
Transport Systems
Specificity of pumps in distal convoluted tubule.
Furosemide Sensitivity
Segment of nephron involved in concentration of urine.
Henle’s Loop
Ions present in renal interstitium, crucial for function.
Electrolytes
Larger molecules in renal interstitium aiding reabsorption.
Energy Compounds
Rate of fluid filtration, typically 125 mL/min.
Fluid Filtration Rate
Process of choosing substances to retain or excrete.
Selective Reabsorption
Site of high-pressure filtration in kidneys.
Glomerular Capillaries
Pathways for reabsorbing substances through tubule walls.
Tubule Reabsorption Routes
Mechanism to adjust GFR via arteriole constriction.
Pressure Regulation