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Infectious Disease (OSI type) > Antiviral > Flashcards

Antiviral Flashcards

1
Q

Antiviral drugs that block viral entry

A
  1. Enfuvi
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2
Q

Most hematotoxic anti-HIV drug

A

Zidovudine

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3
Q

[HIV Antiviral]

Associated with pancreatitis NRTI

A

Didinosine

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4
Q

[HIV Antiviral]

Least hematotoxic NRTI

A

zalcitibine

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5
Q

[HIV Antiviral]

least potent NRTI

A

Lamivudine

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6
Q

[HIV Antiviral]

long half life, OK for pregnant NRTI

A

Emtricitabine

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7
Q

[HIV Antiviral]

Associated with hypersensitivity NRTI

A

Abacavir

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8
Q

[HIV Antiviral: NNRTI]

Associated with nightmares

A

Efivarenz

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9
Q

[HIV Antiviral: Protease inhibitors]

No insulin resistance

A

Atazanavir

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10
Q

Drugs for herpes

A
  1. Foscarnet
  2. Acyclovir
  3. Ganciclovir
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11
Q

Drugs for influenza

A
  1. Amantadine

2. Zanamivir

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12
Q

Drugs for HepB and HepC

A
  1. Lamivudine
  2. Ribavirin
  3. Boceprevir
  4. Sofosbuvir
  5. Interferon alpha
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13
Q

What are the steps in viral replication

A
  1. Attachment
  2. Penetration
  3. Uncoating
  4. Synthesis, nucleic acid
  5. Synthesis protein
  6. PACKaging
  7. release
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14
Q

What is the MOA of antiherpes drug?

A

inhibit viral DNA polymerase,

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15
Q

what activates acyclovir

A

viral thymidine kinase

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16
Q

[Drugs for herpes]

inhibits fusion between HSV envelope and plasma membrane

A

Docosanol

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17
Q

[Drugs for herpes]

flourinated pyrimidine nucleoside

A

Trifluridine

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18
Q

[Drugs for herpes]

inhibit the viral DNA polymerase of shingles and EBV

A

valomaciclovir

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19
Q

[Drugs for herpes]

prodrug of acyclovir

A

Valcyclovir

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20
Q

[Drugs for herpes]

does not cause chain termination

A

penciclovir

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21
Q

[Drugs for herpes]

prodrug converted to penciclovir

A

famciclovir

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22
Q

[Drugs for herpes]

that cause bone marrow suppresion

A

Ganciclovir

Valgancyclovir

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23
Q

CMV resistance to ganciclovir is due to?

A

mutation in viral DNA polymerase

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24
Q

___ given as intraocular implant for CMV retinitis

A

Ganciclovir

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25
Q

Drugs for CMV

A
  1. Ganciclovir
  2. Valganciclovir
  3. Cidofovir
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26
Q

Antiviral which can be given in cases of acyclovir- ajnd ganciclovir-resistance

A

Cidofovir

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27
Q

An antiviral that is a pyrophosphate analog

A

Foscarnet

28
Q

What will you give to HSV strains with no thymidine kinase activity?

A

Foscarnet

29
Q

What are the components of your HAART?

A

2 NRTI

1 PI

30
Q

What are examples of your NRTI

A
  1. Abacavir
  2. Didanosine
  3. Emtricitabine
  4. Lamivudine
  5. Stavudine
  6. Tenofovir
  7. Zalcitabine, Zidovudine
31
Q

[NRTI]

DOC to prevent maternal-fetal HIV transmission

A

Safe for pregnancy

  1. Abacavir
  2. Emtricitabine
  3. Lamivudine
  4. Tenofovir
32
Q

What differentiates NRTI and NNRTI

A
  1. NRTI - phosphorylation needed

2. NNRTI - no phosphorylation needed

33
Q

What are examples of your NNRTI

A
  1. Nevirapine
  2. Efavirenz
  3. Etravirine
  4. Delavirdine
  5. Rilpivirine
34
Q

Cite examples of you protease inhibitors

A

all that ends in ‘NAVIR”

35
Q

Protease inhibitor that cause peripheral neuropathy

A

Atazanavir

36
Q

Protease inhibitor that cause hyperbilirubinemia and nephrolithiasis

A

Indinavir

37
Q

___ binds to gp41 subunit

A

Enfuvirtide (prevents fusion)

38
Q

____ CCR5 receptor antagonist

A

Maraviroc

39
Q

___ integrase inhibitor leading to inhibition of strand transfer

A

rategravir

40
Q

[Drugs for influenza]

inhibit early step replication, prevents uncoating

A

Amantadine

41
Q

[Drugs for influenza]

cause livedo reticularis

A

Amantadine

Rimandatine

42
Q

[Drugs for influenza]

used to treat parkinsonism

A

amantadine

43
Q

[Drugs for influenza]

inhibits neuraminidase

A

Oseltamivir

44
Q

Enzyme used to release progeny virus in influenza

A

neuraminase

45
Q

[Drugs for influenza]

Causes bronchospasm in asthmatics

A

Zanamivir

46
Q

What is the drug of choice for influenza

A

Oseltamivir

47
Q

DOC for H1N1

A

Oseltamivir

48
Q

[HepB and HepC drugs]

what are the contraindications to using interferon alpha for HBV and HCV

A
  1. Autoimmune disease
  2. history of cardiac arrhythmias
  3. Pregnancy
49
Q

[HepB drug]

inhibits HBV DNA polymerase

A
  1. Lamivudine
  2. Adefovir
  3. Dipivoxil
  4. Entecavir
  5. Telbivudine
  6. Tenofovir
  7. Clevudine
50
Q

Drugs used both in hepB and HIV

A

Lamivudine

51
Q

[HepB drug]

causes lactic acidosis, renal and hepatic toxicity

A

Lamivudine

52
Q

HBV and HIV coinfection increases the risk of what of lamivudine is used

A

pancreatitis

53
Q

___ inhibit guanosine triphosphate formation

A

Ribavirin

54
Q

antiviral drugsused for RSV

A

Ribavirin

55
Q

Drug for RSV that uses a monoclonal antibody agains RSV antigen

A

Pavilizumab

56
Q

immune response modifier effective for external genital and perianal warts

A

Imiquimod

57
Q

used to treat subacute sclerosing panencephalitis

A

Inosine acedoben dimerpranol

58
Q

___ a prodrug that become active uridine analog triphosphate. Used to treat HCV

A

Sofosbuvir

59
Q

[HIV Drug]

NRTI given if creatinine clearance is <60

A

Abacavir

60
Q

[HIV Drug]

used for patients 12 years old and above, CD4 >350, non pregnant, not on rifampicin containing regimen

A

Rilpinavir

61
Q

[HIV Drug]

Adolescent >/10 years old

A

2NRTI + 1 NNRTI

Tenofovir + Lamivudine + Efavirenz

62
Q

[HIV Drug]

Children 3 to less than 10 years old

A

2 NRTI + 1 NNRTI

Abacavir + Lamivudine + Efavirenz

63
Q

[HIV Drug]

Neonates with Hct <40%

A

Abacavir over Zidovudine

64
Q

[HIV Drug]

0-2 weeks old

A

Zidovudine + Lamivudine + Nevirapine

65
Q

[HIV Drug]

2 weeks to 3 months old

A

Abacavir

Infectious Disease (OSI type) (24 decks)

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