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Infectious Disease (OSI type) > Antifungal > Flashcards

Antifungal Flashcards

1
Q

Antifungal drug class that alter cell membrane permeability

A

Azoles
Polyenes
Terbinafine

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2
Q

Antifungal drug class that block beta glucan synthesis

A

Echinocandins

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3
Q

Antifungal drug class that block nucleic acid synthesis

A

Flucytosine

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4
Q

Antifungal drug class that disrupt microtubule function

A

Griseofulvin

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5
Q

___ binds to ergosterol forming artificial pores

A

amphotericin B

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6
Q

Amphotericin B cause nephrotoxicity which presents as ____

A

RTA with Mg and K wasting

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7
Q

Amphotericin B is used as systemic treatment for ____

A
  1. Aspergillus
  2. Blastomyces
  3. Candida albicans, crytptococcus
  4. Histoplasma
  5. Mucor
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8
Q

What are the lipid formulations of amphotericin B?

A
  1. Ambisome
  2. Amphotec
  3. Abelcet
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9
Q

Resistance pattern of ampho B

A

decreased level of ergosterol or change in membrane structure

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10
Q

DOC for fungal meningitis

A

Flucytosine

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11
Q

what is the active compound of flucystosine which has a fungistatic effect

A

5FU

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12
Q

what enzyme is used to convert flucytosine to 5-FU

A

cytosine deaminase

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13
Q

5 FU inhibits what enzyme?

A

thimidylate synthase

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14
Q

What is the resistance pattern of flucytosine

A

due to decreased activity of fungal permease and deaminase

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15
Q

____ inhibits ergosterol synthesis by inhibiting fungal P450-dependent enzyme

A

ketoconazole

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16
Q

drug of choice for chromoblastomycosis

A

flucytosine

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17
Q

drug of choice for chronic mucocutaneous candidiasis

A

ketoconazole

18
Q

Antifungal drug that is a potent CYP 450 inducer affecting Phase 1

A

ketoconazole

19
Q

____ interferes to steroid hormone synthesis

A

ketoconazole

20
Q

What is the resistance pattern of ketoconazole?

A

changes in the sensitivity of target enzyme

21
Q

What is the DOC as treatment and prophylaxis to cryptococcal meningitis

A

fluconazole

22
Q

This is an alternative drug to ampho be in the treatment of C. neoformans

A

fluconazole

23
Q

Antifungal drug that has good CNS penetrability

A
  1. Fluconazole
  2. Posaconazole
  3. Voriconazole
24
Q

What is the only azole that has an activity agains rhizopus

A

Posaconazole

25
Q

DOC for sporotrichosis

A

Itraconazole

26
Q

may be used for subcutaneoous chromobastomycosis

A

itraconazole

27
Q

____ inhibits beta glucan synthase decreasing fungal cell wall synthesis

A

Caspofungin

28
Q

What is the salvage therapy for invasive aspergillosis?

A

caspofungin

29
Q

Antifungal drug that can cause histamin release

A

caspofungin

30
Q

Echinocandin that can increase the level of cyclosporin and tacrolimus

A

micafungin

31
Q

[Systemic antifungal]

interferes with microtubule function

A

Griseofulvin

32
Q

[Systemic antifungal]

that can cause disulfram reaction

A

griseogulvin

33
Q

Griseofulvin action is increased by intake of ___

A

fatty meal

34
Q

What is the resistance pattern of griseofulvin

A

decreased transport of drug into fungal cell wall

35
Q

___ inhibits fungal squalene ixidase

A

terbinafine

36
Q

[Systemic antifungal]

DOC for onychomycosis

A

Terbinafine

37
Q

Where does terbinafine acumulate in the skin

A

keratin

38
Q

[Superficial antifungal]

___ binds to fungal cell membrane forming artificial pores

A

nystatyin

39
Q

[Superficial antifungal]

can be used for oropharyngeal, esophageal and vaginal candidiasis

A

Nystatin

40
Q

[Superficial antifungal]

inhibit P450 dependent enyzyme blocking ergosterol synthesis

A

Clotrimazole

41
Q

DOC for pityriasis versicolor

A

clotrimazole

Infectious Disease (OSI type) (24 decks)

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