Antifungal

Question 1

Antifungal drug class that alter cell membrane permeability

Answer 1

Azoles
Polyenes
Terbinafine

Question 2

Antifungal drug class that block beta glucan synthesis

Answer 2

Echinocandins

Question 3

Antifungal drug class that block nucleic acid synthesis

Answer 3

Flucytosine

Question 4

Antifungal drug class that disrupt microtubule function

Answer 4

Griseofulvin

Question 5

___ binds to ergosterol forming artificial pores

Answer 5

amphotericin B

Question 6

Amphotericin B cause nephrotoxicity which presents as ____

Answer 6

RTA with Mg and K wasting

Question 7

Amphotericin B is used as systemic treatment for ____

Answer 7

1. Aspergillus
2. Blastomyces
3. Candida albicans, crytptococcus
4. Histoplasma
5. Mucor

Question 8

What are the lipid formulations of amphotericin B?

Answer 8

1. Ambisome
2. Amphotec
3. Abelcet

Question 9

Resistance pattern of ampho B

Answer 9

decreased level of ergosterol or change in membrane structure

Question 10

DOC for fungal meningitis

Answer 10

Flucytosine

Question 11

what is the active compound of flucystosine which has a fungistatic effect

Answer 11

5FU

Question 12

what enzyme is used to convert flucytosine to 5-FU

Answer 12

cytosine deaminase

Question 13

5 FU inhibits what enzyme?

Answer 13

thimidylate synthase

Question 14

What is the resistance pattern of flucytosine

Answer 14

due to decreased activity of fungal permease and deaminase

Question 15

____ inhibits ergosterol synthesis by inhibiting fungal P450-dependent enzyme

Answer 15

ketoconazole

Question 16

drug of choice for chromoblastomycosis

Answer 16

flucytosine

Question 17

drug of choice for chronic mucocutaneous candidiasis

Answer 17

ketoconazole

Question 18

Antifungal drug that is a potent CYP 450 inducer affecting Phase 1

Answer 18

ketoconazole

Question 19

____ interferes to steroid hormone synthesis

Answer 19

ketoconazole

Question 20

What is the resistance pattern of ketoconazole?

Answer 20

changes in the sensitivity of target enzyme

Question 21

What is the DOC as treatment and prophylaxis to cryptococcal meningitis

Answer 21

fluconazole

Question 22

This is an alternative drug to ampho be in the treatment of C. neoformans

Answer 22

fluconazole

Question 23

Antifungal drug that has good CNS penetrability

Answer 23

1. Fluconazole
2. Posaconazole
3. Voriconazole

Question 24

What is the only azole that has an activity agains rhizopus

Answer 24

Posaconazole

Question 25

DOC for sporotrichosis

Answer 25

Itraconazole

Question 26

may be used for subcutaneoous chromobastomycosis

Answer 26

itraconazole

Question 27

____ inhibits beta glucan synthase decreasing fungal cell wall synthesis

Answer 27

Caspofungin

Question 28

What is the salvage therapy for invasive aspergillosis?

Answer 28

caspofungin

Question 29

Antifungal drug that can cause histamin release

Answer 29

caspofungin

Question 30

Echinocandin that can increase the level of cyclosporin and tacrolimus

Answer 30

micafungin

Question 31

[Systemic antifungal] interferes with microtubule function

Answer 31

Griseofulvin

Question 32

[Systemic antifungal] that can cause disulfram reaction

Answer 32

griseogulvin

Question 33

Griseofulvin action is increased by intake of ___

Answer 33

fatty meal

Question 34

What is the resistance pattern of griseofulvin

Answer 34

decreased transport of drug into fungal cell wall

Question 35

___ inhibits fungal squalene ixidase

Answer 35

terbinafine

Question 36

[Systemic antifungal] DOC for onychomycosis

Answer 36

Terbinafine

Question 37

Where does terbinafine acumulate in the skin

Answer 37

keratin

Question 38

[Superficial antifungal] ___ binds to fungal cell membrane forming artificial pores

Answer 38

nystatyin

Question 39

[Superficial antifungal] can be used for oropharyngeal, esophageal and vaginal candidiasis

Answer 39

Nystatin

Question 40

[Superficial antifungal] inhibit P450 dependent enyzyme blocking ergosterol synthesis

Answer 40

Clotrimazole

Question 41

DOC for pityriasis versicolor

Answer 41

clotrimazole