Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Infectious Disease (OSI type) > Antimycobrials > Flashcards

Antimycobrials Flashcards

1
Q

___ inhibits mycolic acid synthesis

A

isoniazid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

most important drug used in treatment of TB

A

isoniazide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

causes neurotoxicity

A

isoniazid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

___ structural congener of pyridoxine

A

isoniazied

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Isoniazid has a high level of resistance due to a deletion of this gene

A

KatG gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What enzyme is involved in bioactivation in INH

A

catalase-peroxidase enzyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Low level resistance to isoniazid is due to a deletion of what gene>

A

inhA gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

inhA gene targets what enzyme

A

acyl protein reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

___ inhibits DNA-dependent RNA polymerase

A

rifampicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

cause red orang ebody fluids

A

rifampicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

also used for atypical mycobacterial infections

A

rifampicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

a rifampin derivative used to prevent hepatic encephalopathy

A

rifaximin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

___ is the preferred TB drug for AIDS patient

A

rifampicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

resistance pattern of rifampicin

A

changes in drug sensitivity of the polymerase enzyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

bactericidal to actively dividing mycobacteria

A

Pyrazinamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

most hepatotoxic anti TB drug

A

pyrazinamide

17
Q

___ is also known as sterilizing agent used in the first 2 months

A

pyrazinamide

18
Q

resistance pattern of pyrazinamide is via mutation in what gene

A

pncA

19
Q

what are the resistance pattern of pyrazinamide?

A
  1. mutation in pncA

2. Efflux systems

20
Q

___ Inhibits arabinosy transferase

A

ethambutol

21
Q

arabinosyl transferase is involved in the sysnthesis of what component in mycobacterial cell wall

A

arabinogalactan

22
Q

resistance to ethambutol is due to

A

mutation in emb gene

23
Q

___ binds to S12 ribosomal subunit

A

Streptomycin (an aminoglycoside)

24
Q

____ has no cross-resistance with INH

A

Ethionamide

25
Q

[leprosy drug]

inhibits folic acid synthesis

A

dapsone

26
Q

[leprosy drug]

back up drug for PCP pneumonia

A

dapsone

27
Q

___ is a repository form of dapsone which has drug action that can last for several months

A

acedapsone

28
Q

[leprosy drug]

binds to guanine bases in bacterial DNA

A

clofazimine

29
Q

[leprosy drug]

cause skin discoloration

A

clofazimine

30
Q

What is the mycobacterial prophylaxis for patients with CD4 count less than 50

A
  1. Clarithromycin
  2. Azithromycin
  3. with or without Rifabutin
31
Q

What is the treatment for atypical mycobacterial infection?

A
  1. Azithromycin OR clarithromycin
  2. Ethambutol
  3. Rifabutin

Infectious Disease (OSI type) (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions