Antimalarials Flashcards
Can cause dose dependent toxicity
BOV, dizziness, flushed skin, sweaty skin, nausea, vomiting, tinnitus
Quinidine
Cite examples of tissue schizonticides
- Primaquine
2. Atovaquone
Cite examples of bloodschizonticides
- Chloroquine
- Quinine
- Mefloquine
- Atovaquone
- Pryimethamine
- Artemisinin
- Halofantrine
- Artemisinin
Cite examples of gametocides
- Primaquine
Cite examples of sporonticides
- Proguanil
2. Pyrimethamine
___ is a blood schizontocide that prevents polymerization of heme into hemozoin;
also given to amebic liver abscess and RA
chloroquine
___ is a blood schizontocide that may cause auditory impairment, psychosis, QT prolongation, precipitate porphyria
Chloroquine
___ is a blood schizontocide that complexes with DNA to prevent strand separation
Quinine
SE: headache, tinnitus, vertigo
Quinine
This is a case of cinchonism
Can cause blackwater fever
quinine
DOC for malaria in pregnant patient
Quinine
To limit the toxicity of quinine, you should give
- Doxycycline or
2. Clindamycin
___ is a blood schizontocide. another alternative to quinine in acute attacks of falciparum
Mefloquine
___ is a blood schizontocide wherein the SE is psychosis
Mefloquine
___ is a blood gametocide that forms electron-transferring redox compounds that act as cellular oxidants
Primaquine
___ is a blood gametocide that is the radical cure for P. vivax and P. ovale
Primaquine
___ is a blood gametocide that is the termina cure for P. vivax and P. ovale
Primaquine
___ is a blood gametocide that is used to treat PCP pneumonia
Primaquine
___ is a blood gametocide that is used to kill hypnozoites
Primaquine
In atovaquone-proguanil combination, which is a blood and tissue schizontocide?
Atovaquone
- disrupt ETC
In atovaquone-proguanil combination, which is a sporonticide?
Proguanil
- inhibits folate synthesis
___ is used to treat chlorquine resistant P. falciparum in all its stages
Atovaquone-Proguanil
____ is an blood schizonticide that sequentially blocks folic acid synthesis.
Sulfadoxine-Pyrimethamine
___ chemoprophylaxis for multidrug resistant malaria; also a tetracycline
Doxycycline
Common side effect of doxycycline is headache without organic lesion. also called
pseudotumor cerebri
Used in combination with artemether to treat chloroquine reistant malaria, and severe falciparum malaria
Lumfantrine
___ is a blood schizontozide that forms toxic free radicals in malarial food vacuole.
Artemisinin
What is the DOC for uncomplicated falciparum malaria in the philippines
Artemether-Lumefantrine (Co-Artem)
not safe during the first trimester
What is the DOC for P. vivax and P. ovale
- Chloroquine then
2 Primaquine
What is the DOC for severe P. falcoparum
- Artesunate then Doxycycline OR
1. Clinamycin or Co-arten
[Malaria prophylaxis]
In chlorquine-sensitive areas
Chlorquine 500mg/tab 1 tab weekly
[Malaria prophylaxis]
In chlorquine-resistant areas
- Mefloquine 250mg/tab 1 tab weekly
2. Malarone (Atovaquone250/Proguanil 100)/tab 1 tab OD
[Malaria prophylaxis]
In multidrug resistant areas
- Doxycycline 100mg/tab 1 tab OD
[Malaria prophylaxis]
for P. vivax and P. ovale
- Primaquine 30mg OD x 2 weeks
An immunomodulatory agent used to treat malaria
mepacrine
