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Infectious Disease (OSI type) > Antimalarials > Flashcards

Antimalarials Flashcards

1
Q

Can cause dose dependent toxicity

BOV, dizziness, flushed skin, sweaty skin, nausea, vomiting, tinnitus

A

Quinidine

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2
Q

Cite examples of tissue schizonticides

A
  1. Primaquine

2. Atovaquone

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3
Q

Cite examples of bloodschizonticides

A
  1. Chloroquine
  2. Quinine
  3. Mefloquine
  4. Atovaquone
  5. Pryimethamine
  6. Artemisinin
  7. Halofantrine
  8. Artemisinin
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4
Q

Cite examples of gametocides

A
  1. Primaquine
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5
Q

Cite examples of sporonticides

A
  1. Proguanil

2. Pyrimethamine

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6
Q

___ is a blood schizontocide that prevents polymerization of heme into hemozoin;

also given to amebic liver abscess and RA

A

chloroquine

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7
Q

___ is a blood schizontocide that may cause auditory impairment, psychosis, QT prolongation, precipitate porphyria

A

Chloroquine

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8
Q

___ is a blood schizontocide that complexes with DNA to prevent strand separation

A

Quinine

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9
Q

SE: headache, tinnitus, vertigo

A

Quinine

This is a case of cinchonism

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10
Q

Can cause blackwater fever

A

quinine

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11
Q

DOC for malaria in pregnant patient

A

Quinine

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12
Q

To limit the toxicity of quinine, you should give

A
  1. Doxycycline or

2. Clindamycin

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13
Q

___ is a blood schizontocide. another alternative to quinine in acute attacks of falciparum

A

Mefloquine

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14
Q

___ is a blood schizontocide wherein the SE is psychosis

A

Mefloquine

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15
Q

___ is a blood gametocide that forms electron-transferring redox compounds that act as cellular oxidants

A

Primaquine

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16
Q

___ is a blood gametocide that is the radical cure for P. vivax and P. ovale

A

Primaquine

17
Q

___ is a blood gametocide that is the termina cure for P. vivax and P. ovale

A

Primaquine

18
Q

___ is a blood gametocide that is used to treat PCP pneumonia

A

Primaquine

19
Q

___ is a blood gametocide that is used to kill hypnozoites

A

Primaquine

20
Q

In atovaquone-proguanil combination, which is a blood and tissue schizontocide?

A

Atovaquone

  • disrupt ETC
21
Q

In atovaquone-proguanil combination, which is a sporonticide?

A

Proguanil

  • inhibits folate synthesis
22
Q

___ is used to treat chlorquine resistant P. falciparum in all its stages

A

Atovaquone-Proguanil

23
Q

____ is an blood schizonticide that sequentially blocks folic acid synthesis.

A

Sulfadoxine-Pyrimethamine

24
Q

___ chemoprophylaxis for multidrug resistant malaria; also a tetracycline

A

Doxycycline

25
Q

Common side effect of doxycycline is headache without organic lesion. also called

A

pseudotumor cerebri

26
Q

Used in combination with artemether to treat chloroquine reistant malaria, and severe falciparum malaria

A

Lumfantrine

27
Q

___ is a blood schizontozide that forms toxic free radicals in malarial food vacuole.

A

Artemisinin

28
Q

What is the DOC for uncomplicated falciparum malaria in the philippines

A

Artemether-Lumefantrine (Co-Artem)

not safe during the first trimester

29
Q

What is the DOC for P. vivax and P. ovale

A
  1. Chloroquine then

2 Primaquine

30
Q

What is the DOC for severe P. falcoparum

A
  1. Artesunate then Doxycycline OR

1. Clinamycin or Co-arten

31
Q

[Malaria prophylaxis]

In chlorquine-sensitive areas

A

Chlorquine 500mg/tab 1 tab weekly

32
Q

[Malaria prophylaxis]

In chlorquine-resistant areas

A
  1. Mefloquine 250mg/tab 1 tab weekly

2. Malarone (Atovaquone250/Proguanil 100)/tab 1 tab OD

33
Q

[Malaria prophylaxis]

In multidrug resistant areas

A
  1. Doxycycline 100mg/tab 1 tab OD
34
Q

[Malaria prophylaxis]

for P. vivax and P. ovale

A
  1. Primaquine 30mg OD x 2 weeks
35
Q

An immunomodulatory agent used to treat malaria

A

mepacrine

Infectious Disease (OSI type) (24 decks)

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