Anticorpi Flashcards

1
Q

p-ANCA

A

Churg-Strauss, poliangioite microscopica, colangite sclerosante primaria

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2
Q

Anticorpi anti-nucleo (ANA)

A

LES

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3
Q

c-ANCA

A

Wegener

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4
Q

Anticorpi anti-DNA a doppia elica (anti-dsDNA)

A

LES, nefrite lupica

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5
Q

Anticorpi anti-centromero (ACA)

A

sclerosi cutanea limitata

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6
Q

Anticorpi anti-istone

A

LES da farmaci

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7
Q

Anticorpi anti-peptide ciclico citrullinato (CCP)

A

artrite reumatoide

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8
Q

Anticorpi anti-antigeni nucleari estraibili sono gli …

A

anti-SS-A (Ro)
anti-SS-B (La)
anti-RNP: connettivite mista
anti-Jo-1: dermatomiosite, polimiosite, S. Ab anti sintetasi
anti-Sm: LES (il più specifico)
anti-Scl-70: sclerosi cutanea diffusa

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9
Q
  • anti-SS-A (Ro)
  • anti-SS-B (La)
A
  • anti-SS-A (Ro): LES neonatale, S. Sjogren, LES subacuto
  • anti-SS-B (La): LES neonatale, S. Sjogren → protegge rene se presente con anti-Ro
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10
Q

anti-RNP

A

anti-RNP: connettivite mista

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11
Q

anti-Jo-1

A

anti-Jo-1: S. Ab anti sintetasi (sdr mani da meccanico) dermatomiosite, polimiosite,

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12
Q

anti-Sm

A

anti-Sm: LES (il più specifico)

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13
Q

anti-Scl-70

A

anti-Scl-70: sclerosi cutanea diffusa

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14
Q

Fattore reumatoide (RF)

A

artrite reumatoide

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15
Q

Anti RNA polimerasi I e III

A

sclerodermia (crisi renale sclerodermica)

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16
Q

Anticorpi anti-fosfolipidi (APA)

A

sindrome da anticorpi anti-fosfolipidi

  • Anticorpi anti-cardiolipina
  • Anticorpi anti-beta-2 glicoproteina 1
  • Lupus anticoagulant (LA)
17
Q

Anticorpi nel diabete

A
  • Anticorpi citoplasmatici anti-insula pancreatica (ICA)
  • Anticorpi anti-decarbossilasi dell’acido glutammico (GADA)
  • Anticorpi-2 associati all’insulinoma (IA-2A)
  • Anticorpi anti-insulina (IAA)
  • Anticorpi anti-trasportatore dello zinco 8 (ZnT8A)
18
Q

Anticorpi celiachia

A
  • Anticorpi anti-transglutaminasi tissutale (anti-tTG)
  • Anticorpi anti-gliadina (AGA)
19
Q

Anticorpi anti-fattore intrinseco (IFA)

A

anemia perniciosa

20
Q

tiroidite di Hashimoto

A
  • Anticorpi anti-perossidasi tiroidea (TPOAb)
  • Anticorpi anti-tireoglobulina (TgAb)
21
Q

Anticorpi anti-muscolo liscio (ASMA)

A

epatite autoimmune

22
Q

Anticorpi anti-mitocondriali (AMA)

A

Colangite biliare primitiva.
Non confondere con Colangite Sclerosante Primitiva (p-ANCA)

23
Q

Anticorpi anticorpi anti microsomi epato-renali di tipo 1 (LKM-1)

A

epatite autoimmune

24
Q

Anticorpi anti-membrana basale glomerulare (GBM)

A

Sindrome di Goodpasture

25
Q

miastenia gravis

A
  • Anticorpi anti-recettore dell’acetilcolina (AChR)
  • Anti-chinasi muscolo specifica (MUSK)
26
Q

Anti-SRP

A

miosite necrotizzante immunomediata (IMNM)

27
Q

Anti-HMGCR

A

miosite necrotizzante da statine

28
Q

Anti Mi2

A

dermatomiosite responsiva

29
Q

Anti MDA5

A

dermatomiosite amiopatica

30
Q

Anti TIF-1

A

miosite paraneoplastica

31
Q

Anti-P (anti-ribosomi)

A

Lupus con coinvolgimento del SNC

32
Q

Mab suffissi

A
  • a - topo
  • e - criceto
  • i - primate
  • o - ratto
  • u - umano
  • xi - chimera
  • zu - umanizzato
33
Q

Particella sorgente dei mab

A
  • kit - interleuchina
  • li/lim - linfociti/sistema immunitario
  • toxa - tossine