Antibiotic Man Primary Care Flashcards

1
Q

When to give antibiotics for suspected meningitis

A

Give antibiotics if non-blanching rash, in combination with signs of meningism or sepsis, and time permits.

If time transfer is > 1 hour

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2
Q

What antibiotics are given for meningitis

A

Benzylpenicillin (IV/IM) 1.2g or if known anaphylaxis Cefotaxime 2g (IV/IM)

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3
Q

Meningitis prophylaxis for contacts

A

Ciprofloxacin

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4
Q

Orbital cellulitis

A

transfer to hospital immediately

Ceftriaxone IV 2g bd + Flucloxacillin IV 2g qds + Metronidazole IV 500mg tds (Penicillin allergy: seek advice)

Step down to Co-amoxiclav PO 625mg tds (10-14 days total)

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5
Q

Ophthalmic shingles

A

Start treatment up to 7 days after onset of rash

Refer to ophthalmology if eye involvement

Aciclovir 800mg 5 times daily or valaciclivor 1g tds (7 days) + lubricating eye drops if lesions near eyelid

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6
Q

Dental abscess

A

Penicillin V 500mg qds or metronidazole 4000mg tds (5 days)

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7
Q

tonsilitis/pharyngitis/sore throat

A

if >/= 4 on FeverPain

1st line- penicillin V 1g bd or 500mg qds (5 days)
2nd line- clarithromycin 500mg bd (5 days)

Unable to swallow: Benzylpenicillin IV 1.2g qds (penicillin allergy: clarithromycin IV 500mg bd)

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8
Q

Sinusitis

A

If ≤10 days symptoms there is no benefit from antibiotics unless clear evidence of systemic illness. If >10 days multiple or worsening symptoms consider back up antibiotic.

1st LINE Penicillin V 500mg qds or 1g bd (5 days)
2nd LINE Doxycycline 200mg day 1 then 100mg daily (5 days total)

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9
Q

Epiglottitis/supraglottitis

A

medical emergency- hospital transfer

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10
Q

Otitis media

A

Most cases will resolve without antibiotics and if used, they generally reduce symptom duration by <1 day. Consider antibiotics if otorrhoea present.

1st LINE Amoxicillin 500mg tds
2nd LINE Clarithromycin 500mg bd (5 days)

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11
Q

Otitis externa

A

Provide information on aural care. Mild – do not swab. Acetic acid 2% tds (EarCalm®) continuing for 2 days after
resolution (max 7 days). Moderate – do not swab. Sofradex® or Otomize® tds.
Severe- seek ENT guidance

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12
Q

Oral candidiasis

A

1ST LINE Miconazole gel qds or Nystatin 1ml qds

2ND LINE Fluconazole 50mg daily (Immunocompromised 100mg) (7 days)

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13
Q

*Clindamycin oral dosing

A

<50kg 300mg tds
50-90kg 450mg tds
>90kg or very severe illness 600mg tds or 450mg

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14
Q

Peritonsilar cellulitis

A

Benzylpenicillin IV 1.2g qds or Penicillin V oral 500mg qds or 1g bd.
Total duration IV/PO: 10 days
Penicillin allergy: Clindamycin* oral (10 days)

If unable to swallow IV Clindamycin 600mg – 1.2g qds

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15
Q

Supraglottitis

A

Ceftriaxone IV 2g od

Send blood cultures

Step down to Co-amoxiclav PO 625mg tds
(or in penicillin allergy: Doxycycline PO 100mg bd +
Metronidazole 400mg tds)

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16
Q

Post tonsillectomy haemorhage

A

If evidence of infection Amoxicillin IV 1g tds or Clarithromycin IV 500mg bd

Switch to oral Amoxicillin 500mg tds or Clarithromycin 500mg bd as soon as possible

Duration: 7 days total IV/PO

Consider use of tranexamic acid if no evidence of infection

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17
Q

acute rhinosinusitis

A

Penicillin V oral 500mg qds or 1g bd (7 days)

Penicillin allergy: Doxycycline 200mg on day 1 then 100mg thereafter (7 days)

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18
Q

Epistaxis

A

If packing has been in for >48hours – Flucloxacillin PO 1g qds – STOP when packing removed

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19
Q

Acute parotitis

A

Consider mumps as differential diagnosis. Ensure strict oral hygiene and appropriate management of dry mouth.

Flucloxacillin 500mg qds plus Metronidazole 400mg tds (5 days)

Penicillin allergy: Doxycycline 100mg od plus Metronidazole 400mg tds

20
Q

Facial cellulitis dental/mandibular/sinus source

A

PO Co-amoxiclav 625mg tds or Clindamycin* (7 days)

21
Q

peri-orbital/pre-septal cellulitis

A

Co-amoxiclav PO 625mg tds or IV 1.2g tds (pencillin allergy: Clindamycin*) Duration: 7-10 days

22
Q

Skull base osteomyelitis

A

Piperacillin/tazobactam IV 4.5g tds (as 30min infusion).

If penicllin allergy or oral route suitable Ciprofloxacin PO
750mg bd.

Sensitivities essential.

Treat for 6 weeks initially then reassess.
If continued inflammation on scan or high CRP continue for a further 6 weeks. May require up to 6-12 months of treatment

23
Q

Exacerbation of COPD

A

Treat if increased sputum purulence. If no increased sputum purulence no antibiotics unless pneumonia or consolidation on CXR.

1st LINE Amoxicillin 500mg tds
2nd LINE Doxycycline 200mg day 1 then 100mg daily (5 days total)

24
Q

Acute cough/bronchitis

A

Antibiotics give no significant benefit in clinical improvement but may be considered in the frail elderly.
1st LINE Amoxicillin 500mg tds
2nd LINE Doxycycline 200mg day 1 then 100mg daily (5 days total)

25
Q

Community acquired pneumonia

A

0 = Usually treat at home
Amoxicillin 1g tds or Doxycycline 200mg day 1 then 100mg daily (5 days)

1-2= usually treat at home
Consider hospital referral (in particular if major co-morbidity)

3-4= Urgent hospital admission
Give Amoxicillin 1g oral or Benzylpenicillin 1.2g IV before transfer (withhold if known anaphylaxis)

26
Q

Non-severe CDI

A
  • Treat with oral metronidazole 400mg tds for 10 days
  • Document indication and duration on medicine chart
  • If oral route not available IV metronidazole 500mg tds
  • Rehydrate patient

If no improvement after 5 days of treatment with
metronidazole or worsens at any time, switch to treatment with vancomycin 125mg qds for 10 days.

If after 10 days of treatment diarrhoea still persists, seek
specialist advice and investigate other pathologies that could be responsible for diarrhoea.

Test of cure should NOT be performed

27
Q

Severe CDI

A

-Treat with oral vancomycin 125mg qds for 10 days
• Document indication and duration on medicine chart
• If oral route not available give via NG tube
• Rehydrate patient and consider referral to hospital or healthcare facility if patient at home

28
Q

Ileus in severe CDI

A

If ileus is detected or NG route not available treat with IV metronidazole 500mg tds plus vancomycin 500mg qds (via NG or intracolonic) until ileus is resolved.

29
Q

Antibiotics in diverticulitis

A

Uncomplicated acute diverticulitis may respond to analgesia and dietary modification. If antibiotics are indicated use Metronidazole 400mg tds plus Co-trimoxazole 960mg bd for 5 days

30
Q

Uncomplicated female lower UTI

A

Single symptom: self care advice

≥2 symptoms: dipstick for nitrites if feasible and <65 years

+ve & mild symptoms: self care advice or back up prescription

+ve & severe symptoms:
1ST LINE Nitrofurantoin 100mg MR bd
2nd LINE Trimethoprim 200mg bd (3 days)

31
Q

RECURRENT UTI WOMEN (>2/6month or >3/year)

A

Consider other options before prophylaxis.
Some women may wish to try cranberry or d-mannose to reduce recurrence.

> 3/year Methenamine 1g bd may be considered – no evidence of benefit if renal tract abnormalities or
neuropathic bladder.

Consider a prescription for ‘stand-by’ antibiotic prior to considering prophylaxis.

If antibiotic prophylaxis considered follow national advice on counselling prior to initiation, review after 3-6 months with a view to stopping at 6 months.
Trimethoprim 100mg or Nitrofurantoin 50-100mg at night (or post coital).
Consider renal/respiratory cautions.

32
Q

Pyelonephritis (male or female)

A

Send MSSU. Co-trimoxazole 960mg bd or Co-amoxiclav 625mg tds (7 days)

33
Q

CKD UTIs

A

trimethoprim or pivemecillinam

34
Q

Uncatheterised male UTI

A

Send MSSU.
1st LINE Nitrofurantoin MR 100mg bd or 50mg qds
2nd LINE Trimethoprim 200mg bd (7 days)

35
Q

Catheterised UTIs

A

DO NOT USE URINALYSIS. DO NOT TREAT UNLESS CLINICAL SIGNS/SYMPTOMS OF INFECTION.

Antibiotic prophylaxis for UTI if catheter in situ is not recommended. Check decision aid before prescribing.
Co-trimoxazole 960mg bd or Co-amoxiclav 625mg tds (7 days).
Change catheter as soon as possible.

36
Q

Prostatitis

A

ofloxacin 200mg bd or ciprofloxacin 500mg bd

If high risk CDI: trimethoprim 200mg bd (all 28 days)

37
Q

Epididymo-orchitis

A

Send MSSU, gonorrhoea and chlamydia tests
If STI likely (<35 or new partner in 3/12) Doxycycline 100mg bd (14 days)

If UTI likely (>35 no new partner) Ofloxacin 200mg bd or ciprofloxacin 500mg bd (14 days)

38
Q

Uncomplicated chlamydia

A

Doxycycline 100mg bd (7 days)

If tolerant Azithromycin 1g od day 1 then 500mg od for 2 days

39
Q

PID

A

metronidazole 400mg bd + ofloxacin 400mg bd (14 days)

40
Q

bacterial vaginosis

A

metronidazole 400mg bd (5 days) or 2g single dose

41
Q

Vulvovaginal candidiasis

A

Fluconazole 150mg single dose or clotrimazole 500mg pessary single dose

42
Q

Cellulitis

A

Flucloxacillin 1g qds or Doxycycline 100mg bd (5 days)

If systemically unwell or not responding refer to ID: may be suitable for outpatient IV therapy (OHPAT).

Consider swabbing for Panton-Valentine Leucocidin if recurrent boils or abscesses.

If history or risk of MRSA Doxycycline 100mg bd

43
Q

Diabetic foot

A

Mild: Flucloxacillin 1g qds or Doxycycline 100mg bd.

Moderate: Flucloxacillin 1g qds + Metronidazole 400mg tds
or
Doxycycline 100mg bd + Metronidazole 400mg tds.

44
Q

Impetigo

A

Localised lesions: topical hydrogen peroxide 1% cream or fusidic acid 2% cream tds (5 days)
If more widespread lesions:
1st LINE Flucloxacillin 500mg qds
2nd LINE Clarithromycin 500mg bd (5 days)

45
Q

Chickenpox

A

Consider antiviral if patient presents within 24 hours of onset of rash or immunocompromised:
Aciclovir 800mg 5 times daily (7 days)

46
Q

Shingles

A

Must present within 72 hours of onset of rash: Aciclovir 800mg 5 times daily or Valaciclovir 1g tds (7 days)

47
Q

Bites dog/cat/human

A

1ST LINE Co-amoxiclav 625mg tds
2ND LINE metronidazole 400mg tds + doxycycline 100mg bd

PROPHYLAXIS FOR UNINFECTED BITE: 3 days TREATMENT FOR INFECTED BITE: 5 days