Anti-virals (year 2) Flashcards
what section of the innate immune system does interferon fall under?
molecular
what are interferons?
cytokine (intercellular hormones)
what types of disease are interferons important in fighting? (2)
viral
tumours
what are the main types of interferon? (3)
alpha
beta
gamma
what cells produce IFNalpha and IFNbeta?
virally infected cells
what cells produce IFNgamma?
activated lymphocytes
what are the functions of interferon? (2)
activate antiviral resistance in nearby cells
recruit immune cells
what does interferon do within the cell? (2)
reduces translation
cleaves RNA and DNA
what interferons can be used in animals? (2)
human alpha interferon
recombinant feline interferon omega
how is human alpha interferon administered?
oral
parenteral
what makes human alpha interferon ineffective after 3-7 weeks?
antibody production (especial when dose is high)
what type of interferon is recombinant feline interferon omega?
type 1
what more common interferon is recombinant feline interferon omega related to?
IFNalpha
what diseases has human alpha interferon be used in? (2)
FIV
FeLV
what disease has recombinant feline interferon omega be used in?
canine parvovirus
FeLV
what do nucleoside analogues do when they insert into DNA?
terminates the chain, not allowing other molecules to join
what is the main side effect if nucleoside analogues?
anaemia
what have nucleoside analogues been used to treat?
FIV
FeLV
what is an example of a nucleoside analogues?
acyclovir
what is the major disadvantage of intra-ocular acyclovir use?
ointment must be applied 5 times a day
what can L-lysine be used to reduce?
conjunctivitis
FHV shedding
