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Pharmacology > Anti-virals (year 2) > Flashcards

Anti-virals (year 2) Flashcards

1
Q

what section of the innate immune system does interferon fall under?

A

molecular

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2
Q

what are interferons?

A

cytokine (intercellular hormones)

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3
Q

what types of disease are interferons important in fighting? (2)

A

viral

tumours

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4
Q

what are the main types of interferon? (3)

A

alpha
beta
gamma

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5
Q

what cells produce IFNalpha and IFNbeta?

A

virally infected cells

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6
Q

what cells produce IFNgamma?

A

activated lymphocytes

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7
Q

what are the functions of interferon? (2)

A

activate antiviral resistance in nearby cells

recruit immune cells

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8
Q

what does interferon do within the cell? (2)

A

reduces translation

cleaves RNA and DNA

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9
Q

what interferons can be used in animals? (2)

A

human alpha interferon

recombinant feline interferon omega

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10
Q

how is human alpha interferon administered?

A

oral

parenteral

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11
Q

what makes human alpha interferon ineffective after 3-7 weeks?

A

antibody production (especial when dose is high)

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12
Q

what type of interferon is recombinant feline interferon omega?

A

type 1

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13
Q

what more common interferon is recombinant feline interferon omega related to?

A

IFNalpha

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14
Q

what diseases has human alpha interferon be used in? (2)

A

FIV

FeLV

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15
Q

what disease has recombinant feline interferon omega be used in?

A

canine parvovirus

FeLV

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16
Q

what do nucleoside analogues do when they insert into DNA?

A

terminates the chain, not allowing other molecules to join

17
Q

what is the main side effect if nucleoside analogues?

A

anaemia

18
Q

what have nucleoside analogues been used to treat?

A

FIV

FeLV

19
Q

what is an example of a nucleoside analogues?

A

acyclovir

20
Q

what is the major disadvantage of intra-ocular acyclovir use?

A

ointment must be applied 5 times a day

21
Q

what can L-lysine be used to reduce?

A

conjunctivitis

FHV shedding

Pharmacology (25 decks)

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