Anti-thrombotics (year 2) Flashcards
what is a thrombus?
solid clot in vessel
what is a thrombus made of? (3)
platelets
fibrin
trapped blood cells
what is required for a thromboembolism?
blood flow abnormalities
endothelial damage
hypercoagulability
what could cause endothelial damage?
trauma catheterisation neoplasia parasites amyloidosis
what could cause abnormal blood flow?
hypoperfusion hypovolaemia heart failure vasoconstriction prolonged immobility
what are arterial thrombosis predominately made by?
platelets
what are venus thrombosis predominately made by?
fibrin
RBCs
what are the types of therapy for thrombosis? (2)
thrombolytic
preventative
what approaches to thrombolytic therapy is there?
rt-PA
streptokinase
urokinase
surgical extraction
what approaches are there to preventive thrombosis therapy?
anti-PLT drugs
heparins
vitamin K antagonists
what is the full name of rt-PA drugs?
recombinant tissue plasminogen activators
what is the mode of action of rt-PA?
enhance transformation of plasminogen to plasmin
what is a risk of using rt-PA?
risk of spontaneous bleeding
when should rt-PA be given?
within hours of the clot forming
what is the mechanism of action of streptokinase?
enhances plasmin formation