ANCA Vasculitis

Question 1

What conditions are associated with perinuclear anti-neutrophil cytoplasmic antibody (pANCA)?

Answer 1

eosinophilic granulomatosis with polyangiitis
microscopic polyangiitis
(may also be cANCA positive)

Question 2

What conditions are associated with cytoplasmic anti-neutrophil cytoplasmic antibody (cANCA)?

Answer 2

granulomatosis with polyangiitis
(may also be pANCA positive)

Question 3

What is the difference between EGPA and GPA?

Answer 3

GPA - triad of predominantly ENT symptoms, LRT symptoms and golmerulonephritis (haematuria and often rapidly progressive glomerulonephritis)

EGPA - asthma, eosinophilia

Question 4

What is the common acute treatment of ANCA vasculitis?

Answer 4

Cyclophosphamide and high dose steroids (more complicated that this but probs don’t need to know it)

Question 5

What antibody treatment can be used second line in ANCA vasculitis?

Answer 5

Rituximab (anti-CD20 on B cells)