AG2-Hypersensitivity disorders

Question 1

4 types of hypersensitivities?

Answer 1

Type 1 immediate, IgE mediated; Type 2 cytotoxic (tissue specific); type 3 immune complex mediated; type 4 cell-mediated

Question 2

Antibodies associated with type 2 tissue specific hypersensitivity?

Answer 2

IgM or IgG targeting surface antigens on specific cells or tissues

Question 3

Examples of type 2 hypersensitivities

Answer 3

Acute hemolytic reactions and hemolytic disease of the newborn (HDN)

Question 4

Signs of acute hemolytic transfusion reaction

Answer 4

agitation, chills, burning at infusion site, pain in chest, back, or abd; HA, N/V, tachypnea/dyspnea, fever, flushing, edema, pallor, tachycardia, hypotension, hematuria, late anuria, late DIC, shock, renal failure.

Question 5

Signs of hemolytic disease of the newborn

Answer 5

jaundice, pallor, hepatosplenomegaly, anemia

Question 6

Examples of type 3 hypersensitivities

Answer 6

lupus, RA, vasculitis, post streptococcal immune complex glomerulonephritis, serum sickness, scleroderma

Question 7

How is Type IV hypersensitivity different than the others?

Answer 7

Mediated by T cells, not antibodies

Question 8

Examples of Type 4

Answer 8

positive TB skin test, contact dermatitis, graft rejection, Hashimoto’s thyroiditis, T1DM

Question 9

Within what time frame does a type 4 hypersensitivity occur?

Answer 9

within 24 to 72 hours after a sensitized person is exposed to the offending antigen

Question 10

What is atopy?

Answer 10

name given to a hypersensitivity rxn that occurs in a previously sensitized host to a foreign substance

Question 11

What is the emergency dose of Epi for anaphylactic reaction?

Answer 11

0.3-0.5mL of 1mg/mL of concentration