5.7: Human immunodeficiency virus (HIV) Flashcards
The human immunodeficiency virus (HIV) causes the disease acquired immune deficiency syndrome (AIDS).
Among contagious diseases, it is a relative newcomer, having first been diagnosed when?
Among contagious diseases, AIDS is a relative newcomer, having first been diagnosed in 1981
The structure of HIV:
What is on the outside?
On the outside is a lipid envelope
The structure of HIV:
On the outside is a lipid envelope, embedded in which are what?
On the outside is a lipid envelope, embedded in which are peg-like attachment proteins
The structure of HIV:
On the outside is a lipid envelope, embedded in which are peg-like attachment proteins.
What is there inside the lipid envelope?
Inside the lipid envelope there is a protein layer called the capsid
The structure of HIV:
On the outside is a lipid envelope, embedded in which are peg-like attachment proteins.
Inside the lipid envelope there is a protein layer called the capsid that does what?
Inside the lipid envelope there is a protein layer called the capsid that encloses:
- 2 single strands of RNA
- Some enzymes
The structure of HIV:
On the outside is a lipid envelope, embedded in which are peg-like attachment proteins.
Inside the lipid envelope there is a protein layer called the capsid that encloses 2 single strands of DNA and some enzymes.
What is one of these enzymes?
One of these enzymes is reverse transcriptase
The structure of HIV:
On the outside is a lipid envelope, embedded in which are peg-like attachment proteins.
Inside the lipid envelope there is a protein layer called the capsid that encloses 2 single strands of DNA and some enzymes.
One of these enzymes is reverse transcriptase, so-called because it does what?
One of these enzymes is reverse transcriptase, so-called because it catalyses the production of DNA from RNA
The structure of HIV:
On the outside is a lipid envelope, embedded in which are peg-like attachment proteins.
Inside the lipid envelope there is a protein layer called the capsid that encloses 2 single strands of DNA and some enzymes.
One of these enzymes is reverse transcriptase, so-called because it catalyses the production of DNA from RNA - The reverse reaction to what?
One of these enzymes is reverse transcriptase, so-called because it catalyses the production of DNA from RNA - The reverse reaction to that carried out by transcriptase
The structure of HIV:
On the outside is a lipid envelope, embedded in which are peg-like attachment proteins.
Inside the lipid envelope there is a protein layer called the capsid that encloses 2 single strands of DNA and some enzymes.
One of these enzymes is reverse transcriptase, so-called because it catalyses the production of DNA from RNA - The reverse reaction to that carried out by transcriptase.
The presence of reverse transcriptase, and consequent ability to do what, means that HIV belongs to a group of viruses called what?
- The presence of reverse transcriptase
- Consequent ability to make DNA from RNA
,means that HIV belongs to a group of viruses called retroviruses
HIV replication:
Being a virus, HIV cannot do what?
Being a virus, HIV cannot replicate itself
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
What is the genetical material in HIV?
The genetic material in HIV is RNA
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
The genetic material in HIV is RNA.
What does RNA use?
RNA uses reverse transcriptase
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which does what?
Reverse transcriptase is an enzyme which:
- Takes the viral RNA
- Copies it to make DNA
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, what can the virus do?
In this way, the virus can insert DNA made from its RNA into the human genome
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, the virus can insert DNA made from its RNA into the human genome.
The DNA copies of the virus RNA is what by an enzyme called what?
The DNA copies of the virus RNA is spliced into the host’s DNA by an enzyme called integrase
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, what does HIV do?
Following infection, HIV:
- Enters the bloodstream
- Circulates around the body
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
What readily binds to what?
A protein on the HIV readily binds to a protein called CD4
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, what does HIV attach most frequently to?
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
What fuses with the cell-surface membrane?
The protein capsid fuses with the cell-surface membrane
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
What enter the T helper cell?
The:
1. RNA
2. Enzymes
of HIV enter the T helper cell
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
What is the genetic material in HIV?
The genetic material in HIV is RNA
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
What does RNA use?
RNA uses reverse transcriptase
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which does what?
Reverse transcriptase is an enzyme which:
- Takes the viral DNA
- Copies it to make DNA
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, what can the virus do?
In this way, the virus can insert DNA made from its RNA into the human genome
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, the virus can insert DNA made from its RNA into the human genome.
What does the HIV reverse transcriptase do?
The HIV reverse transcriptase converts the virus’ RNA into DNA
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, the virus can insert DNA made from its RNA into the human genome.
The HIV reverse transcriptase converts the virus’ RNA into DNA.
What happens by an enzyme called integrase?
The DNA copies of the virus RNA is spliced into the host’s DNA by an enzyme called integrase
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, the virus can insert DNA made from its RNA into the human genome.
The HIV reverse transcriptase converts the virus’ RNA into DNA.
The DNA copies of the virus RNA is spliced into the host’s DNA by an enzyme called integrase.
What happens to the newly made DNA?
The newly made DNA is moved into the helper T cell’s nucleus
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, the virus can insert DNA made from its RNA into the human genome.
The HIV reverse transcriptase converts the virus’ RNA into DNA.
The DNA copies of the virus RNA is spliced into the host’s DNA by an enzyme called integrase.
The newly made DNA is moved into the helper T cell’s nucleus, where it is what?
The newly made DNA is moved into the helper T cell’s nucleus, where it is inserted into the cell’s DNA
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, the virus can insert DNA made from its RNA into the human genome.
The HIV reverse transcriptase converts the virus’ RNA into DNA.
The DNA copies of the virus RNA is spliced into the host’s DNA by an enzyme called integrase.
The newly made DNA is moved into the helper T cell’s nucleus, where it is inserted into the cell’s DNA.
The HIV DNA in the nucleus creates what?
The HIV DNA in the nucleus creates messenger RNA (mRNA)
HIV replication:
Being a virus, HIV cannot replicate itself.
Instead HIV uses its genetic material to instruct the host cell’s biochemical mechanisms to produce the components required to make new HIV.
It does so as follows:
Following infection, HIV enters the bloodstream and circulates around the body.
A protein on the HIV readily binds to a protein called CD4.
While this protein occurs on a number of different cells, HIV attaches most frequently to T helper cells.
The protein capsid fuses with the cell-surface membrane.
The RNA and enzymes of HIV enter the T helper cell.
The genetic material in HIV is RNA.
RNA uses reverse transcriptase.
Reverse transcriptase is an enzyme which takes the viral DNA and copies it to make DNA.
In this way, the virus can insert DNA made from its RNA into the human genome.
The HIV reverse transcriptase converts the virus’ RNA into DNA.
The DNA copies of the virus RNA is spliced into the host’s DNA by an enzyme called integrase.
The newly made DNA is moved into the helper T cell’s nucleus, where it is inserted into the cell’s DNA.
The HIV DNA in the nucleus creates messenger RNA (mRNA), using what?
The HIV DNA in the nucleus creates messenger RNA (mRNA), using the cell’s enzymes