[57] Henoch-Schonlein Purpura Flashcards
What is Henoch-Schonlein Puprura (HSP)?
A small vessel vasculitis with particular characteristics
What are the characteristics of HSP?
- Skin rash on extensor surface
- Arthralgia
- Periarticular oedema
- Abdominal pain
- Glomerulonephritis
What age range is HSP most common in?
3-10 years
When does the incidence of HSP peak?
In winter months
How does HSP begin?
Genetic predisposition and antigen exposure increases circulating IgA levels and disrupts IgG synthesis
What happens to IgA and IgG in HSP?
They interact to form complexes that activate complement and are deposited in affected organs precipitating an inflammatory response with vasculitis
What are the risk factors for HSP?
- Male
- White
- Asian
What are the symptoms of HSP?
- Fever
- Rash
- Joint pain
- Colicky abdominal pain
If there is GI involvement in HSP how can this present?
Haematemesis and melena
Describe the rash in HSP
Initially urticarial then maculopapular, purpuric and palpable
Where does the rash in HSP typically affect?
Buttocks and extensor surfaces
What is normally spared by the HSP rash?
The trunk
How many patients with HSP are affected by arthralgia?
2/3
What joints are particularly affected by arthralgia in HSP?
Knees and ankles
What is diagnosis based on?
Combination of symptoms with supportive tests