47. Regenerative therapy using enamel matrix proteins.

Question 1

General purpose of using enamel matrix proteins (Emdogain®) in regenerative therapy

Answer 1

• Biomodify root surface=>
• Application of amelogenins=>enamel matrix protein=>
• Promoting periodontal regeneration by mimicking events during development of periodontal tissues=>
• Stimulates regeneration of periodontal ligament, cementum, and alveolar bone
• Aims=>clinical attachment gain, pocket probing depth (PPD) reduction, bone gain

Question 2

Enamel matrix derivatives (EMD), and what they consist of

Answer 2

• Biologically active regenerative materials=>
• Enamel matrix proteins of porcine origin
• Water
• Propylene glycol alginate (which forms a gel)

Question 3

Osteoinductive potential of enamel matrix proteins, and primary goals of their use

Answer 3

• Osteoinductive potential=>stimulate formation of new bone
• Gain clinical attachment
• Reduce pocket probing depth (PPD)
• Achieve bone gain

Question 4

Indications for using enamel matrix proteins in regenerative therapy

Answer 4

• Intrabony defects w/ three-wall morphology or well-supported two-wall defects up to 5 mm
• Gingival recession
• Furcation involvement

Question 5

How enamel matrix proteins affect fibroblasts and other cells in the periodontal environment

Answer 5

• Stimulate fibroblasts and other cells to migrate and proliferate=>
• Production of extracellular matrix and growth factors=>
• Tissue regeneration and healing

Question 6

Benefits of enamel matrix proteins in the early stages of healing

Answer 6

• Improved keratinization
• Enhanced soft tissue healing

Question 7

Help in reducing the risk of infection during the healing process

Answer 7

Enamel matrix proteins have antimicrobial and antiseptic actions

Question 8

How enamel matrix proteins impact post-surgical pain and swelling

Answer 8

• Reduce post-surgical pain and swelling=>
• More comfortable and faster recovery